新型1,1''''-双乙酰基二茂铁席夫碱的合成

通过1,1'-双乙酰基二茂铁双肼腙与芳醛(酮)的缩合反应,合成了6个新型1,1'-双乙酰基二茂铁席夫碱,其结构经1H NMR, IR和元素分析表征.     

液相色谱－电致化学发光检测系统的检测性能研究

使用几种常见的反相液相色谱介质和４种多环化合物对液相色谱交流电致化学发光检测系统的性能进行了测试，结果表明：检测器对４种化合物的检测限均可达到２．０ｎｇ，线性范围达３个数量级。     

One-pot synthesis of substituted indolo[1,2-a]quinolines under transition-metal-free conditions

A simple and efficient one-pot synthesis of substituted indolo[1,2-a]quinolines under transition-metal-free conditions has been developed. When 2-fluorobenzaldehyde was treated with substituted 2-methylindoles in the presence of Cs₂CO₃, the desired products were typically obtained in good to excellent yields. This reaction sequence involves a nucleophilic aromatic substitution and a Knoevenagel condensation reaction. Our mechanistic investigation revealed that both reactions could proceed as an intermolecular reaction in the first step.     

A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines

The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp³-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.     

A Peri‐tetracene Diradicaloid: Synthesis and Properties

Peri‐acenes are good model compounds for zigzag graphene nanoribbons, but their synthesis is extremely challenging owing to their intrinsic open‐shell diradical character. Now, the successful synthesis and isolation of a stable peri‐tetracene derivative PT‐2ClPh is reported; four 2,6‐dichlorophenyl groups are attached onto the most reactive sites along the zigzag edges. The structure was confirmed by X‐ray crystallographic analysis and its electronic properties were systematically investigated by both experiments and theoretical calculations. It exhibits an open‐shell singlet ground state with a moderate diradical character (y₀=51.5 % by calculation) and a small singlet–triplet gap (ΔE_S‐T=?2.5 kcal mol^?1 by SQUID measurement). It displays global aromatic character, which is different from the smaller‐size bisanthene analogue BA‐CF3 .     

A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens

Chemical investigation of the ethanolic extracts of the dried leaves of Bergenia purpurascens led to the isolation and identification of a new aromatic glycoside, 1-O-β-D-glucopyranosyl-2-methoxy-3-hydroxyl-phenylethene (1), along with other 19 known compounds (2–20). The structure of compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro anti-proliferative activities of compound 1 on five human cancer cell lines were evaluated. The results showed that compound 1 possessed the most potent effects with the IC₅₀ values of 14.36 ± 1.04 μM against T24 cells. The further bioactivity analysis showed that compound 1 induced apoptosis of T24 cells, and altered anti- and pro-apoptotic proteins, leading to mitochondrial dysfunction and activation of caspase-3 for causing cell apoptosis. The present investigation illustrated compound 1 might be used as a potential antitumour chemotherapy candidate.     

Basalt fibers functionalized with gold nanoparticles for in‐tube solid‐phase microextraction

Basalt fibers were functionalized with gold nanoparticles and characterized by scanning electron microscopy and energy‐dispersive X‐ray spectroscopy. An in‐tube solid‐phase microextraction device was developed by packing the functionalized basalt fibers in a polyether ether ketone tube. The device was connected into high performance liquid chromatography equipment with a diode array detector to build online enrichment and analysis system. Eight polycyclic aromatic hydrocarbons were used as model analytes, important factors including sampling rate, sampling volume, organic solvent content in sample, and desorption time were investigated. Linear range (0.01–20 μg/L), detection limits (0.003–0.015 μg/L), and enrichment factors (130–1628) were given by the online analysis method. Relative standard deviations (n = 5) of extraction repeatability on one tube and tube‐to‐tube repeatability were less than 5.2 and 14.7%, respectively. The analysis method was applied to detect polycyclic aromatic hydrocarbons in environmental water samples, and relative recoveries ranged from 87 to 128%.     

Oxa[7]superhelicene: A π‐Extended Helical Chromophore Based on Hexa‐peri‐hexabenzocoronenes

A novel π‐extended “superhelicene” based on hexa‐peri‐hexabenzocoronenes (HBCs) has been synthesized by an efficient four‐step synthetic procedure starting from diphenyl ether. Comprehensive structural analysis of the helicene was performed by NMR spectroscopy and mass spectrometry measurements together with X‐ray analysis. Physicochemical analysis of the superhelicene and suitable HBC references revealed it had outstanding fluorescent features with quantum yields of over 80 %.     

Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Reactions of Aldehyde Acyl Anions with either Diarylmethyl or Allylic Carbonates

Benzylation and allylation of aldehyde acyl anions were enabled by the merger of a thiazolium N‐heterocyclic carbene (NHC) catalyst and a palladium/bisphosphine catalyst in a synergistic manner. Owing to the mildness of the reaction conditions, various functional groups were tolerated in the substrates.