Cleavage of ortho-(dodeca-1,3-diynyl)triazenes in HCl or HBr medium and subsequent cyclization of the resulting diazonium salts is investigated. In the absence of a strong electron-withdrawing substituent, the reaction affords 3-alkynyl-4-bromo(chloro)cinnolines as the only product. A methoxycarbonyl group promotes hydrolysis of 4-halocinnolines which results in the formation of by-products: furo[3,2-c]cinnoline and cinnolinone. Substitution of bromine in 3-(alk-1-ynyl)-4-bromocinnolines is achieved with methylamine, Na2S and ethynylbenzene affording pyrrolo[3,2-c]cinnoline, thieno[3,2-c]cinnoline and 3,4-diethynylcinnoline, respectively. 相似文献
The first palladium-catalyzed coupling of vinyl tosylates with arylsulfinate salts is described. A variety of cyclic and acyclic vinyl tosylates were coupled with aryl sulfinate salts using 2.5 mol % Pd2(dba)3/5.0 mol % XantPhos to give vinyl aryl sulfone products in good yields. The coupling was extended to the preparation of a cyclopropyl vinyl sulfone. 相似文献
Easy and direct : Regioselective Mizoroki–Heck‐coupling reactions using heteroaromatic tosylates as electrophiles were achieved, thus providing direct and easy access to highly functionalized α‐heteroarylvinyl amides and ethers.
Solvolyses of tosylates IIB and IIC in a variety of solvents were found to give excellent linear log k -YBnOTs plots (R = 0.997 and SD = 0.022) and negative ΔS≠ for IIB , but slight deviations (R = 0.987 and SD = 0.047) from lineation and positive ΔS≠ for several cases for IIC . Limiting SN1 mechanisms with steric hindrance to resonance and solvent intervention at the cationic transition state could thus be confirmed. The inconsistency between theoretical and observed trend of ΔH≠ is attributed to the neglect of solvent effect in MO calculations. Deductions linking theoretical calculation and solvolytic experiments should be drawn with caution. 相似文献
In what represents the first examples of fluxional sulfonyl derivatives, the tosyl group in the couple 4-isopropyltropone/6-isopropyltropone (3/4), the tosyl or mesyl groups in the couple colchicine/isocolchicine (5/6 or 7/8), and the tosyl group in the couples of colchicinoids 9/10 and 11/12, were observed to undergo thermally-induced shift between the two tropolone-like oxygen atoms, likely via a bipyramidal intermediate; recycling of tosylates or mesylates of biologically inactive isocolchicinoids into the corresponding tosylates or mesylates of biologically active colchicinoids affords synthetic value to the unselective tosylation or mesylation of colchiceine. 相似文献
Summary. A novel process for the one-step chemoselective conversion of a variety of alcoholic tosylates into carbamates serving as
protected amines was developed using benzyltrimethylammonium hydroxide (Triton-B) in the presence of gaseous carbon dioxide.
Thus carbamate esters of different amines were prepared in very good to excellent yields.
Present address: Institute of Organic and Biomolecular Chemistry, Georg-August University, D-37077, G?ttingen, Germany 相似文献
In recent years, palladium catalyzed arylation of olefins, the Heck reaction, has evolved as a powerful synthetic tool for organic chemists1. Since its discovery in the early seventies2, the reaction has undergone several modifications especially with regard to solvents, catalysts and additives. As a result, today Heck reaction is the most widely used transition metal catalyzed carbon-carbon bond forming reaction in organic synthesis3. However, despite all these modifications, little atten… 相似文献
Metal–organic framework (MOF) composite, viz. Cu-BTC@Fe3O4 (BTC is 1,3,5-benzenetricarboxylate), was prepared and utilized for the synthesis of aryl α-chlorobenzyl ketones from arenediazonium salts and arylacetylenes in moderate to good yields. This reaction proceeded via a radical domino process. The catalyst could be readily recovered with an external permanent magnet, with slight decrease in its activity after successive six runs. 相似文献