Novel glucosamine hydrochloride functionalized water‐soluble conjugated polyfluorene was easily synthesized through Cu(I)‐catalyzed azide/alkyne “click” ligation and Suzuki coupling polymerization. The water‐solubility and biocompatibility of the polymer were improved after grafting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single‐stranded DNA was studied by spectrofluorometric titration.
In the present paper, the electronic band structure, density of states (DOS), and projected density of states (PDOS) analysis of thiocarbamide hydrochloride are reported. Calculations of the electronic properties have been carried out on the basis of fully self-consistent pseudopotential method using DFT. The results show that near the Fermi level, more prominent densities of states are seen between -8 eV and -6 eV in the valence band mainly due to the Cl-3p, N-2p and S-3p orbitals. 相似文献
A simple isocratic reversed-phase high-performance liquid chromatographic method (RP-HPLC) was developed for the simultaneous determination of buprenorphine hydrochloride, naloxone hydrochloride dihydrate and its major impurity, noroxymorphone, in pharmaceutical tablets. The chromatographic separation was achieved with 10 mmol L−1 potassium phosphate buffer adjusted to pH 6.0 with orthophosphoric acid and acetonitrile (17:83, v/v) as mobile phase, a C-18 column, Perfectsil Target ODS3 (150 mm × 4.6 mm i.d., 5 μm) kept at 35 °C and UV detection at 210 nm. The compounds were eluted isocratically at a flow rate of 1.0 mL min−1. The average retention times for naloxone, noroxymorphone and buprenorphine were 2.4, 3.8 and 8.1 min, respectively. The method was validated according to the ICH guidelines. The validation characteristics included accuracy, precision, linearity, range, specificity, limit of quantitation and robustness. The calibration curves were linear (r > 0.996) over the concentration range 0.22-220 μg mL−1 for buprenorphine hydrochloride and 0.1-100 μg mL−1 for naloxone hydrochloride dihydrate and noroxymorphone. The recoveries for all three compounds were above 96%. No spectral or chromatographic interferences from the tablet excipients were found. This method is rapid and simple, does not require any sample preparation and is suitable for routine quality control analyses. 相似文献
Detection of drug vapors and volatile products of their decomposition is an important, and sometimes the only way to determine the presence of illegal drug traces at the surface of mail items, documents, hands and banknotes. This paper gives the results of experimental studies on the effect of UV irradiation on the sensitivity of a vapor phase detection of cocaine of different origin by a technology of ion mobility increment spectrometry (IMIS). It is shown that the influence of UV irradiation on the surface of cocaine hydrochloride and crack increases the amplitude of IMIS signals by about eight times. We analyzed ions emerged by photolysis of tested cocaine samples using mass-spectrometry with atmospheric pressure ionization (API-MS). The assumption is made about structural formula of volatile products of photolysis of crack and cocaine hydrochloride. By the results of API-MS and IMIS studies on photolysis of cocaine samples it is assumed that compound C10H15NO3 with a molecular weight of 197 amu and ecgonidine methyl ester with a molecular weight of 181 amu are responsible for the increase of an amplitude of IMIS signals upon UV irradiation of samples of crack and cocaine hydrochloride. 相似文献
An HPLC method for quantitative determination of adrenaline hydrochloride injection and noradrenaline bitartrate injection was established and validated with a substitute for the reference substance.Phenylephrine hydrochloride was selected as the substitute for the reference substance of adrenaline and noradrenaline bitartrate.The correction factor of phenylephrine hydrochloride with respect to the reference substance of adrenaline and noradrenaline bitartrate was determined under defined conditions.Adrenal... 相似文献