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31.
Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo
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Dr. Omar F. Khan Edmond W. Zaia Dr. Hao Yin Dr. Roman L. Bogorad Dr. Jeisa M. Pelet Dr. Matthew J. Webber Iris Zhuang Dr. James E. Dahlman Prof. Robert Langer Prof. Daniel G. Anderson 《Angewandte Chemie (International ed. in English)》2014,53(52):14397-14401
A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle‐forming materials was produced wherein the free amines on multigenerational poly(amido amine) and poly(propylenimine) dendrimers were substituted with alkyl chains of increasing length, and evaluated for their ability to deliver siRNA to liver cell subpopulations. Interestingly, two lead delivery materials could be formulated in a manner to alter their tissue tropism within the liver—with formulations from the same material capable of preferentially delivering siRNA to 1) endothelial cells, 2) endothelial cells and hepatocytes, or 3) endothelial cells, hepatocytes, and tumor cells in vivo. The ability to broaden or narrow the cellular destination of siRNA within the liver may provide a useful tool to address a range of liver diseases. 相似文献
32.
Yasunobu Kotani Haruka Yasuda Dr. Kenji Higashiguchi Prof. Kenji Matsuda 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(43):11158-11166
An amphiphilic rectangular-shaped photochromic diarylethene bearing two hydrophobic alkyl chains and two hydrophilic tri(ethylene glycol) chains was synthesized, and its photoinduced morphological transformation in water was investigated. Two unexpected phenomena were revealed in the course of the experiments: a re-entrant photoinduced macroscopic morphological transformation and temperature-dependent kinetic products of supramolecular assembly. When the pure closed-ring isomer was dispersed in water, a re-entrant photoinduced morphological transformation, that is, a photoinduced transition from the hydrated phase to the dehydrated phase and then back to the hydrated phase, was observed by optical microscopy upon irradiation with green light at 20 °C; this was interpreted by the V-shaped phase diagram of the LCST transition. The aqueous assembly of the pure closed-ring isomer was controlled by changing the temperature; specifically, rapid cooling to 15 and 5 °C gave J and H aggregates, respectively, as the kinetic products. The thermodynamic product at both temperatures was a mixture of mostly H aggregate with a small amount of J aggregate. This behavior was rationalized by the temperature-dependent potential energy surface of the supramolecular assembly. 相似文献
33.
《Macromolecular bioscience》2018,18(7)
Herein, a new series of non‐ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C‐10 and C‐18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10−5m and hydrodynamic diameters in the 8–10 nm range and supplemented by cryogenic transmission electron microscopy. Ultraviolet‐visible (UV‐Vis) and fluorescence spectroscopy suggests the effective solubilization of hydrophobic guests by the self‐assembled architectures, with the nanotransporters 12 and 13 possessing the highest encapsulation efficiency of 80.74 and 98.03% for curcumin. Efficient uptake of encapsulated curcumin in adenocarcinomic human alveolar basal epithelial (A549) cells is observed by confocal laser scanning microscopy. Amphiphiles 12 and 13 are non‐cytotoxic at the concentrations studied, however, curcumin encapsulated samples efficiently reduce the viability of A549 cells in vitro. Experimental studies indicate the ability of amphiphile 13 to encapsulate 1‐anilinonaphthalene‐8‐sulfonic acid (ANS) and curcumin with binding constant of 1.16 × 1055m −1 and 1.43 × 106m −1, respectively. Overall, our findings demonstrate the potential of these dendritic amphiphiles for the development of prospective nanocarriers for the solubilization of hydrophobic drugs. 相似文献
34.
Chengzhong Cui Edward M. Bonder Yang Qin Frieder Jäkle 《Journal of polymer science. Part A, Polymer chemistry》2010,48(11):2438-2445
The amphiphilic organoboron block copolymer poly (styreneboronic acid)‐block‐polystyrene ( PSBA‐b‐PS ) has been prepared through a postpolymerization modification route from the silicon‐functionalized block copolymer poly(4‐trimethylsilylstyrene)‐block‐polystyrene ( PSSi‐b‐PS ). PSBA‐b‐PS is obtained through highly selective reaction of PSSi‐b‐PS with BBr3 at room temperature and subsequent hydrolysis of the BBr2‐functionalized intermediate. Transmission electron microscopy studies demonstrate that PSBA‐b‐PS undergoes pH dependent micellization in aqueous solution. Different morphologies could be realized by using different mixtures of water and organic solvents. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2438–2445, 2010 相似文献
35.
Solubility Switching of Metallophthalocyanines and Their Larger Derivatives upon Encapsulation
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Dr. Kei Kondo Prof. Dr. Munetaka Akita Dr. Michito Yoshizawa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(6):1937-1940
Metallophthalocyanines (MPcs) are very useful pigments but scarcely soluble without appropriate functional groups in common solvents. Herein, we report that bent polyaromatic amphiphiles act as excellent solubilizing reagents for nonfunctionalized MPcs and larger MPc derivatives (e.g., CuPc, perhalogenated CuPcs, Cu‐naphthalocyanine, CuPc polymers, and double‐decker MPcs) in neutral water upon encapsulation. The resultant MPc nanocomposites display high stability towards heat and pH change. More importantly, the encapsulated MPcs can be released by simple protocols under mild conditions both into a bulk solvent and onto glass or polymer plates. 相似文献
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39.
Ahmed M. Eissa Michael J.P. Smith Artur Kubilis Jackie A. Mosely Neil R. Cameron 《Journal of polymer science. Part A, Polymer chemistry》2013,51(24):5184-5193
Copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) was used to prepare glycosylated polyethylene (PE)–poly(ethylene glycol) (PEG) amphiphilic block copolymers. The synthetic approach involves preparation of alkyne‐terminated PE‐b‐PEG followed by CuAAC reaction with different azide functionalized sugars. The alkyne‐terminated PE‐b‐PEG was prepared by etherification reaction between hydroxyl‐terminated PE‐b‐PEG (Mn ~ 875 g mol?1) and propargyl bromide and azidoethyl glycosides were prepared by glycosylation of 2‐azidoethanol. Atmospheric pressure solids analysis probe‐mass spectrometry was used as a novel solid state characterization tool to determine the outcome of the CuAAC click reaction and end‐capping of PE‐b‐PEG by the azidoethyl glycoside group. The aqueous solution self‐assembly behavior of these amphiphilic glycosylated polymers was explored by TEM and dye solubilization studies. Carbohydrate‐bearing spherical aggregates with the ability to solubilize a hydrophobic dye were observed. The potential of these amphiphilic glycosylated polymers to self‐assemble via electro‐formation into giant carbohydrate‐bearing polymersomes was also investigated using confocal fluorescence microscopy. An initial bioactivity study of the carbohydrate‐bearing aggregates is furthermore presented. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 5184–5193 相似文献
40.
Yanmei Wang Hisatoyo Morinaga Atsushi Sudo Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》2011,49(3):596-602
A new acid‐labile polymer having acetal moieties in the main chain was synthesized by polycondensation of poly (ethylene glycol) (PEG) and lilial, an aldehyde widely used in fragrance applications. The hydrophobicity of the resulting acetal moiety and the hydrophilicity of the PEG chain allowed the polyacetal to exhibit amphiphilicity. The polyacetal derived from PEG having weight average molecular weight (Mw) of 1000 (PEG1000) was soluble in water and self‐associated to form associates in water. The polyacetals were hydrolyzed in acidic aqueous solutions to release hydrophobic lilial from the systems. The release rate of aldehyde from the polyacetal derived from PEG1000 was higher than that from the polyacetal derived from PEG having Mw of 400 (PEG400). These results supported that the release rate of lilial can be controlled by the chain length of PEG, on which hydrophilicity of polyacetal depends. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 相似文献