Surfactants Used in Food Industry: A Review

The understanding of the formation, structures, and properties of emulsions is essential to the creation and stabilization of structures in food. The increasing use of surfactants, the identification of compounds with low toxicity and good surface activity properties is of great interest. The relevance of the major end points specified in the Organisation for Economic Co-operation and Development (OECD) guidelines for the hazard assessment of food chemicals is critically analyzed and main parameters are acute toxicity, subacute repeated studies, allergy, reproductive toxicity, long-term studies, and mutagenicity tests. We focus this article on surfactant association structures and food colloids. There is almost infinite number of combinations are organized and arranged in very complex internal microstructures with various types of assemblies such as dispersions, emulsions, foams, gels, etc. Low-mass surfactants are very mobile at the interface and they are particularly efficient reducing the interfacial tension. As a result, they rapidly coat the freshly created oil-water interface during emulsification. In this category, we mainly mentioned monoglycerides, lecithins, glycolipids, fatty alcohols and fatty acids. High-mass surfactants cover protein and polysacharide groups. The protein molecule may interpenetrate in the lipid phase to various degrees. The specific binding is predominantly electrostatic: The headgroups of the surfactants bind to groups of opposite charge on the protein. The saturation binding for anionic surfactants is pH-independent and seems to be controlled by the cooperative hydrophobic interactions. Polysaccharides and smallmolecule surfactants are two of the predominant groups of amphiphilic materials that have been explored for the stabilization of emulsions. One of the most important aspects of polymer-surfactant systems is their ability to control stability and rheology over a wide range of composition. Biocompatible, biodegradable, and/or nontoxic emulsion-based formulations have great potential for applications in the food. The combination of particular characteristics such as emulsifying, anti-adhesive and antimicrobial activities presented by biosurfactants suggests potential application as multipurpose ingredients or additives.     

Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor

(1) Background: Two first-in-class racemic dopamine D₁ receptor (D₁R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D₁R and reported lack of intrinsic activity, compound 2 shows promise as a starting point toward the development of small molecule allosteric modulators to ameliorate the cognitive deficits associated with some neuropsychiatric disease states; (2) Methods: Herein, we describe the enantioenrichment of optical isomers of 2 using chiral auxiliaries derived from (R)- and (S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (d- and l-pantolactone, respectively); (3) Results: We confirm both the racemate and enantiomers of 2 are active and selective for the D₁R, but that the respective stereoisomers show a significant difference in their affinity and magnitude of positive allosteric cooperativity with dopamine; (4) Conclusions: These data warrant further investigation of asymmetric syntheses of optically pure analogues of 2 for the development of D₁R PAMs with superior allosteric properties.     

Grundlegende technische Forderungen an Radioisotopen-Meßgeräte

In zunehmendem Maße werden Meßgeräte unter Verwendung von Radionuklid-Strahlungsquellen in der Industrie zum Zweck der Prozeßüberwachung, -messung und -regelung eingesetzt. Unter den rauhen Umgebungsbedingungen kommt es dabei besonders auf eine hohe Zuverlässigkeit der Geräte an, da Störungen oder Ausfälle der Meßtechnik – je nach dem Einsatzort – mitunter sehr unangenehme Ausfälle im Produktionsprozeß zur Folge haben. Ein Beispiel für den Einsatz eines Radioisotopen-Meßgerätes in der industriellen Fertigungstechnik ist die Flächengewichtsmeßanlage FMM 24004. Aus der Vielfalt der bei der Entwicklung solcher Geräte zu beachtenden Festlegungen, Vorschriften und Randbedingungen werden in dieser Arbeit, ohne Anspruch auf Vollständigkeit erheben zu können, einige wesentliche Aspekte dargestellt.     

Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series

1. Download : Download high-res image (157KB)
2. Download : Download full-size image

     

Zur Nomenklatur isotop modifizierter organisch-chemischer Verbindungen

Nach einer kurzen Übersicht über früher vorgeschlagene Nomenklatursysteme werden die wichtigsten der im Jahre 1978 von der IUPAC-Kommission für die Nomenklatur organischer Verbindungen verabschiedeten 35 Regeln zur Nomenklatur isotop modifizierter Verbindungen zusammengestellt und die näher definierten Begriffe einander zugeordnet, Für wichtige Termini werden die englisch- und russischsprachigen Äquivalentbegriffe angegeben. Von einer RGW-Spezialistengruppe erarbeitete ergänzende Regeln werden bekanntgegeben.     

Positive Allosteric Control of Guests Encapsulation by Metal Binding to Covalent Porphyrin Cages

The allosteric control of the receptor properties of two flexible covalent cages is reported. These receptors consist of two zinc(II) porphyrins connected by four linkers of two different sizes, each incorporating two 1,2,3-triazolyl ligands. Silver(I) ions act as effectors, responsible for an on/off encapsulation mechanism of neutral guest molecules. Binding silver(I) ions to the triazoles opens the cages and triggers the coordination of pyrazine or the encapsulation of N,N′-dibutyl-1,4,5,8-naphthalene diimide. The X-ray structure of the silver(I)-complexed receptor with short connectors is reported, revealing the hollow structure with a cavity well-defined by two eclipsed porphyrins. Rather unexpectedly, the crystallographic structure of this receptor with pyrazine as a guest molecule showed that the cavity is occupied by two pyrazines, each binding to the zinc(II) porphyrin in a monotopic fashion.     

Positive and negative AMPA receptor modulators based on tricyclic bispidine derivative: Minor structural change inverts the type of activity

Two new potent AMPA receptor allosteric modulators, 6-(1,3-benzodioxol-5-yl)-1,11-dimethyl-3,6,9-triazatri-cyclo[7.3.1.1^3,11]tetradecane-4,8,12-trione and -4,8-dione were synthesized from 1,3-benzodioxol-5-amine and the corresponding 3,7-dichloroacetyl-3,7-diazabicyclo[3.3.1]-nonanes. In a wide concentration range (10^?12–10^?7 m), the 12-oxo derivative acts as a positive modulator causing the potentiation of the kainate-induced AMPA receptor currents with maximum potentiation at 1 nm (62%) while its analogue without a ketone group has significant (up to 40%) negative modulator effect. Their tentative mechanisms of action were analyzed by means of molecular modelling     

Optimizing Fe-Based Metal-Organic Frameworks through Ligand Conformation Regulation for Efficient Dye Adsorption and C2H2/CO2 Separation

Regulating the structure of metal-organic frameworks (MOFs) by adjusting the ligands reasonably is expected to enhance the interaction of MOFs on special molecules/ions, which has significant application value for the selective adsorption of guest molecules. Herein, two tricarboxylic ligands H₃L−Cl and H₃L−NH₂ were designed and synthesized based on the ligand H₃TTCA by replacing part of the benzene rings with C=C bonds and modifying the chlorine and amino groups on the 4-position of the benzene ring. Two 3D Fe-MOFs ( UPC-60-Cl and UPC-60-NH₂ ) with the new topology types were constructed. As the C=C bonds of the ligands have flexible torsion angles, UPC-60-Cl features three types of irregular 2D channels, while UPC-60-NH₂ has a cage with two types of windows on the surface. The synergistic effect of unique channels and modification of functional groups endows UPC-60-Cl and UPC-60-NH₂ with high adsorption capacity for organic dyes. Compound UPC-60-Cl shows high adsorption capacity for CV (147.2 mg g⁻¹), RHB (100.3 mg g⁻¹), and MO (220.9 mg g⁻¹), whereas UPC-60-NH₂ exhibits selective adsorption of MO (158.7 mg g⁻¹). Meanwhile, based on the diverse pore structure and modification of active sites, UPC-60-Cl and UPC-60-NH₂ show the selective separation of equimolar C₂H₂/CO₂. Therefore, reasonable regulation of organic ligands plays a significant role in guiding the structure diversification and performance improvement of MOFs.     

中国银行系统的宏观审慎监管研究

全球金融危机爆发后,对银行系统实行审慎监管已成为国内外学者及相关监管机构的共识。但目前银行系统的监管研究多为微观审慎监管,宏观审慎监管研究缺乏,尤其是对中国银行网络系统进行动态建模并进行宏观审慎监管的定量研究未见。本文首先利用中国2008至2015年16家上市银行的实际数据构建动态的中国银行网络系统模型,然后使用Component VaR、Incremental VaR、Shapley value EL以及ΔCoVaR四种风险分配机制研究中国银行网络系统的宏观审慎监管方法。研究表明:对中国银行网络系统进行宏观审慎监管能够有效提升其稳定性,并且四种机制相比之下,ΔCoVaR的监管效果最为显著,而Incremental VaR则相对较差。此外,通过宏观审慎资本与银行指标之间的相关性分析,发现Incremental VaR、Shapley value EL以及Component VaR机制下的宏观审慎资本与银行的总资产具有一定的相关性,此时宏观审慎资本可以根据银行的总资产来设置;而ΔCoVaR机制下则不相关,因此宏观审慎资本可以依据各银行的系统性风险贡献大小来设置。     

Protecting workers and the environment: An environmental NGO’s perspective on nanotechnology

Nanotechnology, the design and manipulation of materials at the atomic scale, may well revolutionize many of the ways our society manufactures products, produces energy, and treats diseases. New materials based on nanotechnology are already reaching the market in a wide variety of consumer products. Some of the observed properties of nanomaterials call into question the adequacy of current methods for determining hazard and exposure and for controlling resulting risks. Given the limitations of existing regulatory tools and policies, we believe two distinct kinds of initiatives are needed: first, a major increase in the federal investment in nanomaterial risk research; second, rapid development and implementation of voluntary standards of care pending development of adequate regulatory safeguards in the longer term. Several voluntary programs are currently at various stages of evolution, though the eventual outputs of each of these are still far from clear. Ultimately, effective regulatory safeguards are necessary to provide a level playing field for industry while adequately protecting human health and the environment. This paper reviews the existing toxicological literature on nanomaterials, outlines and analyzes the current regulatory framework, and provides our recommendations, as an environmental non-profit organization, for safe nanotechnology development.