One-Pot Palladium-Catalyzed Ligand- and Metal-Oxidant-Free Aerobic Oxidative Isocyanide Insertion Leading to 2-Amino-substituted-4(3H)-quinazolinones

An efficient, ligand- and metal-oxidant-free, one-pot, cascade aerobic oxidative, palladium-catalyzed, multicomponent reaction has been developed through isocyanide insertion of less active secondary amide and aromatic amine, which leads to 2-amino-substituted-4(3H)-quinazolinones. This approach proves to be one of the simplest methods for the synthesis of this class of valuable bioactive heterocyclic scaffolds.     

Contributions to the Optimization of a Caprolactam Production Plant by Radiotracer Techniques

Residence time spectra and material distributions in an operating caprolactam production plant were measured by means of sodium 24, bromine 82 and technetium 99m. The results of the tracerexperiments contributed to an optimization of the plant.     

Efficient Transition‐Metal‐Free Oxidation of Benzylic and Secondary Alcohols to the Carbonyl Compounds Using an N‐Bromosuccinimide/NH4Cl System

The oxidation of a variety of benzylic and secondary alcohols was achieved in excellent yields using an NBS/NH₄Cl system in aqueous acetonitrile (CH₃CN‐H₂O; 7/3 v/v) at 80°C under very mild conditions.