排序方式: 共有76条查询结果,搜索用时 15 毫秒
71.
Italo A. Sanhueza Mads C. Nielsen Marcel Ottiger Franziska Schoenebeck 《Helvetica chimica acta》2012,95(11):2231-2236
(Trifluoromethyl)stannane reagents such as Bu3SnCF3 are effective in CuI‐mediated trifluoromethylation reactions of aryl iodides. The reactions proceed via the intermediacy of [CuCF3] species. 相似文献
72.
Oxytrifluoromethylation reaction of styrene derivatives and alkynes with external and internal oxygen nucleophiles, catalyzed by copper (I) salts under mild conditions, was developed. Direct formation of a β-trifluoromethylstyrene derivative from a styrene derivative was also achieved by the reaction in the presence of a Brønsted acid. Further transformation of the oxytrifluoromethylated products was conducted to demonstrate their utility. 相似文献
73.
Srinivas Reddy Dubbaka Shashidhar NizalapurAzmi Reddy Atthunuri Manohar SallaThresen Mathew 《Tetrahedron》2014
Synthesis of trifluoromethylated acetylenes by copper-mediated trifluoromethylation of potassium alkynyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is communicated. The trifluoromethylated acetylenes were obtained in good to moderate yields. The presented method tolerates a wide range of aromatic, heteroaromatic, and aliphatic potassium alkynyltrifluoroborates. 相似文献
74.
Nataliya V. Kirij Valeria N. Movchun Wieland Tyrra Hendrik T.M. Fischer 《Journal of fluorine chemistry》2008,129(1):14-21
The reactions of non-activated aldimines with trimethyl(trifluoromethyl)silane and 1 equiv. of tetramethylammonium fluoride proceed via the formation of tetramethylammonium amides which were identified by low-temperature 19F NMR experiments. Consecutive reactions of the salts formed in situ with electrophiles yielded trifluoromethylated amines. Fluoride elimination is observed in the absence of electrophilic substrates leading to the formation of difluoromethylated ketimines. 相似文献
75.
Fei Cong Riccardo S. Mega Jinhong Chen Craig S. Day Prof. Ruben Martin 《Angewandte Chemie (International ed. in English)》2023,62(15):e202214633
Herein, we report a Cu-mediated trifluoromethylation of carbonyl-type compounds and unactivated olefins enabled by visible-light irradiation via σ C(sp3)−C bond-functionalization. The reaction is distinguished by its modularity, mild conditions and wide scope—even in the context of late-stage functionalization—thus offering a complementary approach en route to valuable C(sp3)−CF3 architectures from easily accessible precursors. 相似文献
76.
Dr. Tobias Michael Milzarek Prof. Dr. Jerome Waser 《Angewandte Chemie (International ed. in English)》2023,62(33):e202306128
The first trifluoromethylation of vinylbenziodoxolones (VBX) is reported herein. The synthetic method is based on the use of bench-stable, high-valent copper(III) species, and the reaction can be initiated under thermal conditions and/or irradiation (365 nm) giving access to trifluoromethylated alkenes in a stereoselective fashion. Various VBX reagents derived from tyrosine, cysteine, small peptides, thiols and amides can be used as precursors. The obtained alkenes could be further functionalized by reduction or epoxidation of the trifluoromethylated double bond. Furthermore, the method could be applied in a large-scale batch/flow synthesis and could be conducted under visible light irradiation. 相似文献