Synthese regiospecifique d'un dinucleoside ponte : (O6- desoxyguanosinyl)-1 (N4-desoxycytidyl)-2 ethane

Appropriate protected deoxyguanosine and deoxyuridine derivatives, respectively activated at O⁶ and O⁴ positions by the 3-nitro 1,2,4-triazol 1-yl group, were reacted with ethylene glycol, ethylenediamine or ethanolamine to give monoalkylated nucleosides or cross-linked dimers or cross-linked dinucleosides.