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Iron(III)‐Catalyzed Arylation of Spiro‐Epoxyoxindoles with Phenols/Naphthols towards the Synthesis of Spirocyclic Oxindoles
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Mupeng Luo Rongju Yuan Xuesong Liu Linqian Yu Prof. Wanguo Wei 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(28):9797-9803
An efficient and highly regioselective iron(III)‐catalyzed Friedel–Crafts‐type arylation of spiro‐epoxyoxindoles with phenols was developed for rapid access to 3‐(3‐indolyl)‐oxindole‐3‐methanols, which could be further elaborated into benzofuranyl‐spirooxindoles under Mitsunobu conditions. When spiro‐epoxyoxindoles were reacted with naphthols in the presence of a catalytic amount of FeCl3?6 H2O in dichloromethane, they underwent a tandem Friedel–Crafts‐type arylation and O‐cyclization to yield novel naphthofuranyl‐spirooxindoles in excellent yields. This method is applied to enable the efficient and highly regioselective synthesis of a small‐molecule inhibitor of the sodium channel Nav1.7 (±)‐XEN402, which is currently in a phase IIb clinical trial for the treatment of pain. 相似文献
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以氧化吲哚与邻芳基二甲醛为原料,经Knoevenagel缩合(或Michael,环化反应),制得7个3-五元碳环螺环氧化吲哚(4a~4c,产率67%~86%,d/r值4∶1~10∶1)和4d~4g;4d~4g与哌啶(或四氢吡咯)和多聚甲醛经胺甲基化反应,合成了4个3-五元碳环螺环氧化吲哚(5d~5g),产率55%~67%,d/r值10∶1~20∶1,其结构经~1H NMR,~(13)C NMR和HR-MS(ESI-TOF)表征。采用MTT法研究了4a~4c和5d~5g对人白血病细胞(K562)的体外抗肿瘤活性。结果表明:4b,5d和5f对K562抑制活性较好,IC50分别为29.3μmol·L~(-1),27.4μmol·L~(-1)和34.2μmol·L~(-1),与阳性对照药顺铂(26.8μmol·L~(-1))相当。 相似文献
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Mass magnetization of magnetite nanoparticles was enhanced by disassembling and encapsulating their building nano‐crystallites with water‐soluble starch. Incorporation of iodine into the as‐prepared nano‐conglomerate led to formation of a ternary nano‐complex and further enhancement of its superparamagnetic susceptibility. As an additional evidence for the anomalously heightened superparamagnetic property, the ternary nano‐complex showed lower magnetic remanence and coercivity than the pristine magnetite it was made from. These findings were ascribed to significant changes in, at least, size of the magnetite nano‐crystallites during formation of the nano‐composite. A significant enhancement was also observed in the catalytic efficiency of the nano‐composite, as was successfully exemplified in the synthesis of some novel spiro[oxindole‐dihydropyridine]s via a three‐component reaction between isatins, furan‐2,4(3H,5H)‐dione and aminouracils ‘on water’. 相似文献
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Mei-Hua Shen Chen Li Qing-Song Xu Bin Guo Rui Wang Xiaoqian Liu Hua-Dong Xu Defeng Xu 《中国化学快报》2021,32(7):2313-2316
When treated with an alkoxide base like t-BuOK in aprotic solvent, N-diphenylmethyl imino oxindoles, made conveniently through condensation of corresponding isatins with N-diphenylmethyl amine, are deprotonated to form azaallyl anions. Allylation and alkylation of this type of intermediates proceed smoothly with diverse C-electrophiles. Acidic work up finishes 3-amino-3-allyl/alkyl oxindoles. The overall transformation equals to an umpolung process at the C3 of isatins. 相似文献
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Swetha Yagnam Eda Rami Reddy Rajiv Trivedi Narra Vamshi Krishna Lingamallu Giribabu Balaji Rathod Reddy Shetty Prakasham Balasubramanian Sridhar 《应用有机金属化学》2019,33(4)
A series of bioactive, triazole‐linked benzyl, aryl, sugar and aliphatic conjugates of 3‐ferrocenylidene‐oxindole have been synthesized. A facile 1,3‐dipolar‐Huisgen coupling reaction of the respective azides with the 3‐ferrocenylidene‐oxindole N‐propargyl moiety ( 3 ) gave the corresponding conjugates ( 5a–n ). All the newly synthesized compounds ( 5a–n ) were characterized by 1H‐NMR, 13C‐NMR, HRMS, Fourier transform‐infrared spectroscopy and elemental analysis. The UV–Vis and electrochemical studies of these compounds were performed in dimethylsulfoxide solutions. The structure of compound ( 3 ) was determined by single crystal X‐ray diffraction study. These compounds exhibited moderate to good antimicrobial activity against Gram‐positive and Gram‐negative strains. 相似文献
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Haigang Yu Ying Liu Hui Zhang Hongmei Deng Zhongjiao Ren Weiguo Cao 《Tetrahedron》2010,66(14):2598-8774
A one-pot approach for highly stereoselective synthesis of spirocyclopropyl oxindoles 3 with good to excellent yields from the reaction of isatins 1 and arsonium salts 2 in the presence of K2CO3 is described. The structure of product 3 was confirmed by 1H NMR, 13C NMR, IR, MS, EA, and X-ray diffraction as well. 相似文献
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Karimi Narges Oskooi Hooesin Heravi Majid Saeedi Mina Zakeri Masoumeh Tavakoli Niloofar 《中国化学》2011,29(2):321-323
Some oxindoles derivatives are synthesized from the condensation of indoles with isatins in the presence of green and recycable catalyst [(CH2)4SO3HMIM][HSO4] in water at room temperature. 相似文献