Stapled SC34EK fusion inhibitors with high potency against HIV-1 and improved protease resistance

A single all-hydrocarbon staple introduction in SC34EK can afford a potent HIV inhibitor with high protease resistance for ADIS treatment.     

用于高平均功率自由电子激光器的DC–RF超导腔注入器

北京大学超导加速器实验室提出了新型DC?RF超导腔注入器的设计方案.该注入器由皮尔斯引出结构、1+1/2超导腔组成,可以提供高品质的、CW模式或高占空比(1%以上)的电子束.对该注入器进行了分析计算和设计研究,通过改变超导腔首腔腔形以增加聚焦效果,采取措施缩短阴极到超导腔的距离,从而有效地抑制束流发射度的增长.用PARMELA对该注入器进行束流动力学研究,以确定皮尔斯引出结构的形状以及超导腔的同步相位.计算结果表明这种用于高平均功率自由电子激光的注入器的设计方案是可行的.     

Full period superconducting section physics design for injector Ⅱ of China-ADS

The China Accelerator Driven Subcritical System （China-ADS） project, which is a strategic plan and aims to design and build an ADS demonstration facility, has been proposed and launched actively in China. Injector Ⅱ as one of the parallel injectors of China-ADS, and is prompted by the Institute of Modern Physics （IMP）. In this paper, a new scheme with full period lattice structure for the SC section is proposed. In the new scheme, there are sixteen periods, with one superconducting solenoid and one superconducting cavity included in each period. All of the elements are contained in four eryomodules. The dreadful influence of the mismatch caused by period structural change can be avoided, and the beam quality is favorable. In addition, this new scheme has certain advantages in reducing the project＇s difficulty and construction risk. The details of the design and beam dynamic simulation for the full period lattice structure are given in this paper.     

基于圆柱型硅光子晶体的1×2光下路分束器(英文)

本文设计了一个基于圆柱型硅光子晶体自准直环形腔的1×2光下路分束器.该光下路分束器由三个分光镜和一个反射镜构成,其中窄光束依赖自准直效应进行传输.利用多光束干涉理论分析了光下路分束器中不同出口的理论透射谱,并且利用时域有限差分法对光下路分束器透射谱进行数值模拟计算,其结果与理论预测基本一致.当下路波长为1 550nm时,光下路分束器的自由光谱范围约为30nm,几乎涵盖了整个光通信C波段.由于其小尺寸和全硅材料,本文设计的1×2光下路分束器有望应用于未来的集成光路中.     

First-principles investigation on the elastic stability and thermodynamic properties of Ti₂SC

Using Vanderbilt-type plane-wave ultrasoft pseudopotentials within the generalized gradient approximation(GGA) in the frame of density functional theory(DFT),we have investigated the crystal structures,elastic,and thermodynamic properties for Ti2SC under high temperature and high pressure.The calculated pressure dependence of the lattice volume is in excellent agreement with the experimental results.The calculated structural parameter of the Ti atom experienced a subtle increase with applied pressures and the increase suspended under higher pressures.The elastic constants calculations demonstrated that the crystal lattice is still stable up to 200 GPa.Investigations on the elastic properties show that the c axis is stiffer than the a axis,which is consistent with the larger longitudinal elastic constants(C 33,C 11) relative to transverse ones(C 44,C 12,C 13).Study on Poisson’s ratio confirmed that the higher ionic or weaker covalent contribution in intra-atomic bonding for Ti2SC should be assumed and the nature of ionic increased with pressure.The ratio(B/G) of bulk(B) and shear(G) moduli as well as B/C 44 demonstrated the brittleness of Ti2SC at ambient conditions and the brittleness decreased with pressure.Moreover,the isothermal and adiabatic bulk moduli displayed opposite temperature dependence under different pressures.Again,we observed that the Debye temperature and Gru¨neisen parameter show weak temperature dependence relative to the thermal expansion coefficient,entropy,and heat capacity,from which the pressure effects are clearly seen.     

基于开关电容的双积分环SC振荡器

介绍了开关电容电路及由此构成的SC积分器和SC振荡器。     

Transmission Fluctuation Spectrometry with Spatial Correlation

Transmission fluctuation spectrometry (TFS) is being developed as a new method of particle size analysis. In the early approaches, the particle suspension was illuminated by one beam with finite beam diameter and the transmission signals underwent a process with variable spatial and/or temporal averaging and a subsequent nonlinear operation. The transmission fluctuations were obtained as a spectrum which included the information on particle size distribution and particle concentration. A new approach presented here employs two narrow parallel beams. While changing the beam separation, the transmission fluctuations of these two beams are expressed in terms of the expectancy of the transmission product (ETP). The analytical expression of the ETP through a monolayer is derived and the ETP of a 3‐dimensional suspension is formulated based on the layer model. The deviation between the transition functions of 3‐dimensional suspensions and monolayers is found to be affected by effects from particle overlapping and monolayer structure.     

Experimental determination and calculation of the critical curves for the binary systems of CO2 containing ketone, alkane, ester and alcohol, respectively

A set of variable-volume autoclave with a quartz window was used for the experimental determination of the high-pressure phase equilibria and critical curves. The critical temperatures, pressures, densities and mole volumes in the region near the critical point of CO₂ were examined for eleven binary systems of supercritical CO₂ (SC CO₂) with different kinds of substances (ketone, alkane, ester and alcohol), respectively. The critical curves of the above binary systems were also calculated using an equation of state. The equation consists of a hard body repulsion term and an additive perturbation term, which takes care of the attractive molecular interaction. The calculated data were compared with the experimental data, and yielded good agreements. At the same time, the values of the adjustable parameters, λ, k_σ and k_? were obtained. The critical curves of the above eleven binary systems at higher temperatures and pressures all belong to type I.     

Coordination-Induced N−H Bond Splitting of Ammonia and Primary Amine of CuI−MOFs

We report a porous three-dimensional anionic tetrazolium based Cu^I−MOF 1 , which is capable of cleaving the N−H bond of ammonia and primary amine, as well as the O−H bond of H₂O along with spontaneous H₂ evolution. In the gas-solid phase reaction of 1 with ammonia and water vapor, Cu^I−MOF 1 was gradually oxidized to NH₂−Cu^II−MOF and OH−Cu^II−MOF, through single-crystal-to-single-crystal (SCSC) structural transformations, which was confirmed by XPS, PXRD and X-ray single-crystal diffraction. Density functional theory (DFT) demonstrated that Cu^I−MOF could lower N−H bond dissociation free energy of ammonia through coordination-induced bond weakening and promote H₂ evolution by the reduction potential of 1 . To our knowledge, this is the first example of MOFs that activate ammonia and amine in gas-solid manner.