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Dr. Haibin Xiao Dr. Wen Zhang Prof. Ping Li Prof. Wei Zhang Xin Wang Prof. Bo Tang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(11):4244-4258
The superoxide anion (O2.−) is widely engaged in the regulation of cell functions and is thereby intimately associated with the onset and progression of many diseases. To ascertain the pathological roles of O2.− in related diseases, developing effective methods for monitoring O2.− in biological systems is essential. Fluorescence imaging is a powerful tool for monitoring bioactive molecules in cells and in vivo owing to its high sensitivity and high temporal-spatial resolution. Therefore, increasing numbers of fluorescent imaging probes have been constructed to monitor O2.− inside live cells and small animals. In this minireview, we summarize the methods for design and application of O2.−-responsive fluorescent probes. Moreover, we present the challenges for detecting O2.− and suggestions for constructing new fluorescent probes that can indicate the production sites and concentration changes in O2.− as well as O2.−-associated active molecules in living cells and in vivo. 相似文献