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41.
近年来,羟自由基(^.OH)对DNA氧化损伤已受到广泛关注,但是很少研究^.OH对RNA的氧化损伤。其实,RNA与DNA一样,也是核酸的两大组分之一,也有许多重要功能。所以^.OH攻击RNA也会引起重后果,会造成细胞功能衰退甚至细胞死亡等。为此,我们建立了Vit.C-CuSO4-Phen-H2O2-PNA这一产生和测定^.OH氧化损伤RNA的化学发光体系,以便加强^.OH氧化损伤RNA的研究。通过对本体系测定条件的研究,得出了本体系最佳组方是:Vit.C,CuSO4,Phen,H2O2和RNA,浓度分别为350μmol/L,55μmol/L,350μmol/L,0.2mol/L和20μg/mL,体系pH为5.5,体系终体积为1mL。随后,利用本体系检测了槲皮素,咖啡酸,黄芩甙和芦丁抗^.OH氧化损伤RNA的作用,发现这四种抗氧化剂均能有效抑制^.OH氧化损伤RNA的分子机理,结果发现,^.OH清除剂硫脲几乎抑制全部发光,推测是因硫脲清除了引发剂^.OH所致;O^-.2清除剂SOD只能抑制小部分发光;^1O2清除剂叠氮化钠和苯甲酸都能抑制绝大部分发光。这些事实提示,^.OH是RNA氧化损伤的引发剂;O^-.2只是导致RNA氧化损伤的次要因素,^1O2才是导致RNA氧化损伤的最主要因素。 相似文献
42.
43.
Philip T. Keenan 《Numerical Algorithms》1994,7(2):269-293
We describe a new family of discrete spaces suitable for use with mixed methods on certain quadrilateral and hexahedral meshes. The new spaces are natural in the sense of differential geometry, so all the usual mixed method theory, including the hybrid formulation, carries over to these new elements with proofs unchanged. Because transforming general quadrilaterals into squares introduces nonlinearity and because mixed methods involve the divergence operator, the new spaces are more complicated than either the corresponding Raviart-Thomas spaces for rectangles or corresponding finite element spaces for quadrilaterals. The new spaces are also limited to meshes obtained from a rectangular mesh through the application of a single global bilinear transformation. Despite this limitation, the new elements may be useful in certain topologically regular problems, where initially rectangular grids are deformed to match features of the physical region. They also illustrate the difficulties introduced into the theory of mixed methods by nonlinear transformations. 相似文献
44.
45.
塑料光学元件的清洗、镀膜和胶合 总被引:1,自引:0,他引:1
各种塑料光学元件在光学系统中的应用越来越广泛。作为光学元件,必然涉及清洗、镀膜和胶合等工艺技术问题。本文就塑料光学元件的这三个技术作一介绍。 相似文献
46.
Noora Virtanen Ville Nevalainen Taru Lehtinen Satu Mikkola 《Journal of Physical Organic Chemistry》2007,20(1):72-82
Transesterification of a phosphodiester bond of RNA models has been studied in various buffer solutions, under neutral and slightly alkaline conditions in H2O and D2O. The results show that imidazole is the only buffer system where a clear buffer catalysis on the cleavage of a phosphodiester bond is observed. The rate enhancement in sulphonic acid buffers is smaller, and a sulphonate base, particularly, is inactive as a catalyst. The rate‐enhancing effect of imidazole is, however, catalytic, and the catalytic inactivity of sulphonate buffers can be attributed to their structure and/or charge. The catalysis by imidazole is a complex system which, in addition to first‐order reactions, involves a process that shows a second‐order dependence in imidazole concentration. The latter reaction becomes significant in acidic imidazole buffers (pH < pKa), as the buffer concentration increases. The kinetic solvent deuterium isotope effect kH/kD, referring to first‐order catalysis by imidazole base, is 2.3 ± 0.3. That referring to second‐order catalysis is most probably much larger, but an accurate value could not be obtained. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
47.
Wujie Shi 《Frontiers of Mathematics in China》2007,2(1):123-125
Let G be a finite group, and let π
e
(G) be the set of all element orders of G. In this short paper we prove that π
e
(B
n
(q)) ≠ π
e
(C
n
(q)) for all odd q.
相似文献
48.
49.
This article focuses on discontinuous Galerkin method for the two‐ or three‐dimensional stationary incompressible Navier‐Stokes equations. The velocity field is approximated by discontinuous locally solenoidal finite element, and the pressure is approximated by the standard conforming finite element. Then, superconvergence of nonconforming finite element approximations is applied by using least‐squares surface fitting for the stationary Navier‐Stokes equations. The method ameliorates the two noticeable disadvantages about the given finite element pair. Finally, the superconvergence result is provided under some regular assumptions. © 2006 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 23: 421–436, 2007 相似文献
50.
We report on further developments in the three-dimensional tracking of a particle deep within the tumbling ball charge of
an experimental mill. The experimental X-ray program employing the use of bi-planar X-ray angiography now includes the tracking
of a typical 6 mm bulk charge particle in three dimensions with a spatial resolution that is accurate to within 0.15 mm. The
improved experimental tracking techniques presented were developed for the purpose of generating accurate three-dimensional
particle trajectory data against which to validate a numerical method for the simulation of discrete media, namely the discrete
element method (DEM). These improvements are complimented with techniques for comparing charge profiles between numerical
DEM simulations and three-dimensional experimental trajectory data. 相似文献