银微电极微分电位溶出分析法研究

本文首次报道了银微电极微分电位溶出分析法。用化学刻蚀法方便地制作了银微电极，用于ＤＰＳＡ具有背景值低，分辨率好、精密度及灵敏度高，在不搅拌，仅需一定酸度而酸度而无其它介质的条件下就能测试等优点，对人工试样及自来水样分析，结果令人满意。     

Implementation and efficiency of an automatic peak-purity-control procedure in HPLC-UV-VIS-coupling based on principal component analysis

Summary Based on a thorough knowledge of the actual system precision significance testing of the primary eigen values, resulting from principal component analysis of the two-dimensional data array of HPLC with photodiode-array detection, is a powerful means to uncover unresolved chromatographic peaks. The implementation of this chemometric technique for assuring peak homogeneity and results showing the efficiency for two-component peaks in regard to spectral characteristics, chromatographic resolution and absorbance ratio of the investigated compounds are presented.     

Cyclocondensation of 2-Aminobenzimidazole with Dimedone and Its Arylidene Derivatives

The reactions of 2-aminobenzimidazole with substituted benzaldehydes and dimedone, 2-arylidene derivatives of dimedone, 9-arylhexahydro-1H-xanthene-1,8(2H)-diones and also with dimedone and DMF have been studied. The direction of formation of the pyrimidine ring has been established and discussed. An X-ray structural investigation of 2,2-dimethyl-2,3-dihydrobenzimidazo[1,2-a]quinazolin-4(1H)-one has been carried out.     

Molecular structure of (diethyldithiocarbomoyl)diphenylthiophosphinate

X-Ray study of (diethyldithiocarbomoyl)diphenylthiophosphinate was carried out. AZ-conformation of the diethyldithiocarbomoyl ligand, which results in a short nonvalent intramolecular P...S contact (3.315 Å), is realized in the molecule. Steric hindrances in the molecule increase the P-S-C bond angle to 106.39°.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1978–1980, October, 1995.The work was financially supported by the International Science Foundation (Gram RH1 000).     

Structural Features of Solid Phases and Topology of Phase Diagrams

The paper considers model phase diagrams of binary and ternary systems involving transformations (transitions) of phase equilibria. The relationship between the type of structural solidstate transformation and the type of phase diagram is shown. Topological series of phase diagrams of systems with continuous and limited types of solid solutions are considered, including phase diagrams with polymorphic transitions between intermediate solid phases of variable composition.     

Quantitation of diethylene glycol monoethyl ether in citrus oils

The use of diethylene glycol monoethyl ether as a flavor solvent is restricted. Since existing methods of quantitation are tedious or require sophisticated multi-dimensional GC instrumentation, a simple method has been developed using low cost GC-MS. Monitoring of ions 31 and 45 enables quantitation of DEGEE in essential oils at levels down to 1 μg/g with accuracy equal to or better than 15%.     

Pressure effects on the phase transition of urea adducts withn-paraffins and polyethylene

The decomposition of urea adducts with hydrocarbons is treated as a first-order phase transition and the pressure dependence is studied up to 0.7 GPa for several kinds of adducts. The thermodynamic quantities at the decomposition of the adduct can be analysed as a sum of those quantities of the component materials. The transition from the orthorhombic to the hexagonal form of the adduct with polyethylene is also investigated by X-ray diffraction and the pressure dependence of the lattice parameters is measured for the adducts. The results are compared with the phase transition in the pure paraffin.     

羟基化合物及其葡醛酸苷化学结构与RP—HPLC保留行为相关性研究

采用体外孵育生物合成方法获得羟基化合物葡醛酸苷系列化合物，并对其反相高效液相色谱保留行为及底物与其葡醛酸结合物保留行为相关性进行了研究，建立了相应的结构－色谱保留行为相关性方程及葡醛酸苷类代谢物保留行为的预测方法。将ＱＳＲＲ研究扩展到药物代谢物领域，对药物Ⅱ相葡醛酸化代谢产物的ＨＰＬＣ分析提供了帮助。     

药物分析

本文对国内药物分析在１９９３－１９９５年间的主要进展作了评述。内容包括下述方法在药物分析中的应用：分光光度法、高效液相色谱法、气相色谱法、薄层色谱法、电化学分析法和其它方法等。共引用文献７６１篇。     

Intramolecular electrophilic rearrangements in saturated acyclic systems. Reactivity of the zwitterion derived from triisopropylphosphine and ethyl 2-cyanoacrylate with respect to different types of electrophiles

The reactions of the zwitterion derived from triisopropylphosphine and ethyl 2-cyanoacrylate with mercuric chloride and aryl isothiocyanates containing Cl atoms in the ortho positions of the benzene ring follow an unusual pathway because this zwitterion represents latent triisopropylphosphine due to the reversibility of the reaction of triisopropylphosphine with ethyl 2-cyanoacrylate. The molecular structures of the adducts of triisopropylphosphine with 2,6-dichloro- and 2,4,6-trichlorophenyl isothiocyanates were confirmed by X-ray diffraction study. Protonation of the adduct of triisopropylphosphine with 2,6-dichlorophenyl isothiocyanate occurred at the nitrogen atom, whereas methylation with methyl trifluoromethanesulfonate afforded an S-methylation product. The results of X-ray diffraction study of the resulting compounds are presented.