A solution to the 1D NMR alignment problem using an extended generalized fuzzy Hough transform and mode support

This paper approaches the problem of intersample peak correspondence in the context of later applying statistical data analysis techniques to 1D ¹H-nuclear magnetic resonance (NMR) data. Any data analysis methodology will fail to produce meaningful results if the analyzed data table is not synchronized, i.e., each analyzed variable frequency (Hz) does not originate from the same chemical source throughout the entire dataset. This is typically the case when dealing with NMR data from biological samples. In this paper, we present a new state of the art for solving this problem using the generalized fuzzy Hough transform (GFHT). This paper describes significant improvements since the method was introduced for NMR datasets of plasma in Csenki et al. (Anal Bioanal Chem 389:875-885, 15) and is now capable of synchronizing peaks from more complex datasets such as urine as well as plasma data. We present a novel way of globally modeling peak shifts using principal component analysis, a new algorithm for calculating the transform and an effective peak detection algorithm. The algorithm is applied to two real metabonomic ¹H-NMR datasets and the properties of the method are compared to bucketing. We implicitly prove that GFHT establishes the objectively true correspondence. Desirable features of the GFHT are: (1) intersample peak correspondence even if peaks change order on the frequency axis and (2) the method is symmetric with respect to the samples. Figure From chaos to order: heatmaps of a H-NMR spectral segment prior and post sorting on one peak position. Post sorting sample order reveals that peak positions exhibits distinctive patterns which are modeled by the GFHT to establish correspondence. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.     

顾客延时离开的共享车位预订控制策略研究

基于车位共享用户未按约定时间离开而导致车位使用时间冲突的问题,构建了随机动态规划模型。通过模型,研究了平台的预订控制策略,并针对平台能否拒绝延时需求的情形,设计两种算法对模型进行求解,最后通过数值仿真验证了算法的有效性。研究结果表明：(1)随着预订周期的增加,平台的边际收益会先增加后减少,因此存在最优预订周期;(2)若平台可以决策延时需求是否被接受,则随着延时概率的增加,机会成本将减少,而平台服务率和车位利用率将增加;(3)若平台只能被动接受延时需求,则随着延时概率的增加,平台服务率将减少,而机会成本和车位利用率将增加。     

PIN限幅二极管结温对尖峰泄漏的影响

 建立了PIN二极管的Pspice子电路模型和热模型,模拟了PIN限幅器的瞬态特性。应用FORTRAN语言调用Pspice的仿真数据,计算了PIN二极管结温随输入脉冲变化的情况,讨论了PIN二极管的物理参数与温度的关系,结合结温的升高修改了Pspice软件中PIN二极管的子电路模型参数,模拟得到了不同结温下的瞬态响应曲线以及尖峰泄漏功率与脉冲频率、上升沿、结温的关系。模拟结果表明:输入脉冲的幅度越大,结温增长越快;在不同脉冲频率和上升沿情况下,升高的结温会导致限幅器尖峰泄漏功率增大。