Synthesis of Pyrrolidine Derivatives by the Palladium-Catalyzed Cyclization of N-(2-Cyclohexenyl)bromoacetamide Derivatives

N-(2-Cyclohexenyl)bromoacetamide derivatives underwent intramolecular cyclization to give pyrrolidine derivatives in the presence of a base and a catalytic amount of palladium catalyst.     

聚亚胺酮的合成与性能研究

聚酰胺(PA)、聚醚酮(PEK)和聚酰亚胺(PI)等作为高性能材料已被开发并得到应用.这些高性能材料可用于航空、航天、微电子等高新技术领域[1~5].与此同时,为了满足人们对新材料的需求,科学界对新型高性能材料的开发和应用始终没有停止,且备受关注.本文首先通过傅-克酰基化反应合成     

Palladium-catalyzed cascade synthesis of spirocyclic oxindoles via regioselective C2-H arylation and C8-H alkylation of naphthalene ring

A simultaneous C2-H arylation and C8-H alkylation of naphthalene ring has been achieved by palladiumcatalyzed cascade reaction of N-(2-halophenyl)-2-(naphthalen-1-yl)acrylamides with aryl iodides,which provides an efficient method for synthesizing various aryl-substituted spirocyclic oxindoles.The protocol enables three C-C bonds formation via an intramolecular Heck reaction and sequentially regioselective C-H bond activation.     

Palladium-catalyzed annulation of 2-(aryldiazenyl) aniline with dimethyl sulfoxide to access N-aryl-1H-benzo[d]imidazol-1-amine

A palladium-catalyzed annulation of 2-(aryldiazenyl) aniline and dimethyl sulfoxide was developed to access N-aryl-1H-benzo[d]imidazol-1-amine in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a “CH” fragment during this procedure. It represents a facile pathway leading to benzimidazoles.     

Intramolecular Larock indole synthesis for the preparation of tricyclic indoles and its application in the synthesis of tetrahydropyrroloquinoline and fargesine

A general and efficient strategy for fused tricyclic indoles from substituted 2-halogenanilines via the palladium-catalyzed intramolecular Larock indolization process has been developed. Using this strategy, a number of 3,4- and 3,5-fused indoles with a variety of ring sizes can been prepared. The utility of this method is demonstrated through the synthesis of the known tetrahydropyrrolo[4,3,2-de]quinoline 10 and the first total synthesis of fargesine.     

Palladium-catalyzed direct intramolecular double α-C–H arylation of 1,5-diketone: a strategy for synthesis of Tröger’s base analogues

9-Aryl-2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-diones were straightforwardly prepared via a tandem reaction of easily available ortho-chloroacetophenone and ortho-chlorochalcone catalyzed by PdCl₂(PCy₃)₂.     

A short synthesis of lennoxamine via ynamides

Lennoxamine was synthesized in eight steps from 2,3-dimethoxybenzoic acid via an intermediate ynamide by using palladium-catalyzed Heck-Suzuki-Miyaura domino reactions.     

Stereospecific interconversion of cis- and trans-γ,δ-epoxy α,β-unsaturated ester systems

The unprecedented, stereospecific interconversion of cis- and trans-γ,δ-epoxy α,β-unsaturated ester systems has been realized, which involves the palladium-catalyzed stereospecific alkoxy or hydroxy substitution reaction with double inversion of configuration at the γ-position as the key step. The new methodology is not only applicable to various disubstituted and trisubstituted epoxy unsaturated esters, but also these interconversions proceed with an extremely high degree of stereoselectivity and efficiency.     

Palladium-catalyzed synthesis of quinoxaline derivatives

A palladium-catalyzed reductive N-heteroannulation of enamines derived from 2-nitrobenzenamines forming mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalin-2-ones is described. The reactions are performed using bis(dibenzylideneacetone)palladium(0), 1,3-bis(diphenylphosphino)propane, and 1,10-phenanthroline in DMF under 6 atm of carbon monoxide at 70 °C.     

A convenient new method to construct 1-alkynyl cyclopropanol and its synthetic application to prepare trisubstituted dienones

A new synthetic route was developed via the nucleophilic addition of lithium alkynylide to 1-arylsulfonyl cyclopropanol 1 to afford 1-alkynyl cyclopropanol, which then reacted with aryl iodide to construct trisubstituted cross-conjugated dienones through a palladium-catalyzed process, where the key steps included the regioselective carbopalladation of arylpalladium(II) intermediate across the triple bond of 1-alkynyl cyclopropanol and the ring opening of the cyclopropyl group.