全文获取类型
收费全文 | 39852篇 |
免费 | 2410篇 |
国内免费 | 1895篇 |
专业分类
化学 | 22305篇 |
晶体学 | 234篇 |
力学 | 3930篇 |
综合类 | 534篇 |
数学 | 8152篇 |
物理学 | 9002篇 |
出版年
2024年 | 66篇 |
2023年 | 395篇 |
2022年 | 1056篇 |
2021年 | 1065篇 |
2020年 | 1015篇 |
2019年 | 978篇 |
2018年 | 874篇 |
2017年 | 1102篇 |
2016年 | 1482篇 |
2015年 | 1121篇 |
2014年 | 1589篇 |
2013年 | 2787篇 |
2012年 | 2278篇 |
2011年 | 2061篇 |
2010年 | 1765篇 |
2009年 | 2261篇 |
2008年 | 2221篇 |
2007年 | 2527篇 |
2006年 | 2090篇 |
2005年 | 1893篇 |
2004年 | 1831篇 |
2003年 | 1520篇 |
2002年 | 1168篇 |
2001年 | 961篇 |
2000年 | 935篇 |
1999年 | 839篇 |
1998年 | 789篇 |
1997年 | 709篇 |
1996年 | 645篇 |
1995年 | 625篇 |
1994年 | 548篇 |
1993年 | 455篇 |
1992年 | 423篇 |
1991年 | 362篇 |
1990年 | 329篇 |
1989年 | 216篇 |
1988年 | 219篇 |
1987年 | 136篇 |
1986年 | 119篇 |
1985年 | 142篇 |
1984年 | 112篇 |
1983年 | 58篇 |
1982年 | 94篇 |
1981年 | 55篇 |
1980年 | 45篇 |
1979年 | 74篇 |
1978年 | 33篇 |
1977年 | 14篇 |
1976年 | 22篇 |
1973年 | 9篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
261.
Kuznetsov V. V. Kutepov S. A. Makhova N. N. Lyssenko K. A. Dmitriev D. E. 《Russian Chemical Bulletin》2003,52(3):665-673
A new method was developed for the synthesis of 6-substituted 1,5-diazabicyclo[3.1.0]hexanes and 7-substituted 1,6-diazabicyclo[4.1.0]heptanes by condensation of N-monohalotrimethylene- and N-monohalotetramethylenediamines with carbonyl compounds in the presence of bases. X-ray diffraction studies and quantum-chemical B3LYP/6-31G* calculations demonstrated that the conformations of the resulting bicyclic systems are stabilized by stereoelectronic interactions. As a result, a boat conformation prevails in 1,5-diazabicyclo[3.1.0]hexanes, whereas the energies of chair, half-chair, and boat conformations of 1,6-diazabicyclo[4.1.0]heptanes are equalized. 相似文献
262.
几种改进的CoMFA方法比较研究血小板活化因子拮抗剂 总被引:6,自引:1,他引:6
由于传统的比较分子场分析(CoMFA)方法本身存在一些缺陷,使得分子的叠合 规则以及叠合分子的空间取向和空间位置等因素对q~2的影响很大,因此相继提出 了几种改进的CoMFA方法。为了优化CoMFA结果,应用传统的CoMFA方法和交叉验证 的R~2引导的区域选择法(q~2-GRS)、全取向搜索法(AOS)、全空间搜索法(APS) 以及比较分子相似性指数(CoMSIA)等四种改进的CoMFA方法,对18个pinusolide类 衍生物这类新发现的血小板活化因子(PAF)拮抗剂进行了比较研究。结果表明四 种改进的CoMFA方法得到的q~2值均比传统CoMFA的高。q~2-GRS方法得到的q~2值有 所提高,但综合结果并不理想,AOS与APS得到的q~2较为理想,而在CoMSIA中, q~2几乎不受空间取向或空间位置的影响。同时我们引人基于样本的偏最小二乘法 (SAMPLS)取代原AOS/APS程序中的传统PLS进行统计分析,明显提高了其运行速 度。最后,根据q~2最高的CoMFA模型和CoMSIA模型设计了几个预测活性更高的 pinusolide类似物。 相似文献
263.
A. M. Shestopalov A. P. Yakubov D. V. Tsyganov Yu. M. Emel'yanova V. N. Nesterov 《Chemistry of Heterocyclic Compounds》2002,38(10):1180-1189
Substituted 6-aminopyrano[2,3-c]pyrazoles were synthesized by the two-component condensation of arylidenemalononitriles and substituted 5-pyrazolones or three-component condensation of aromatic aldehydes, malononitrile, and substituted 5-pyrazolones. It was established by X-ray crystallographic analysis that pyranopyrazoles exist in the 2H and not the 1H tautomeric form. 相似文献
264.
The investigated materials have similar routes of thermal decomposition; i.e. they lose their crystal water first, then at
a higher temperature their structural one. At least the result TiP2O7 goes through a phase change at about 1000 K. The amorphous titanium phosphate lost its crystal and structural water at higher
temperature than those of crystalline forms. Both α- and γ-titanium phosphates and also their transition metal containing
forms have layered structure. In case of α- and γ-forms after the loss of crystal water a phase change occurs which is followed
by the decomposition of the molecule. Various transition metals containing γ-titanium phosphates lose their crystal water
at the same temperature, with the exception of Ni containing ones. The process is finished in this case at temperature 90
K higher than that of the others.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
265.
Three procedures, matrix matching, plasma optimisation and single-point standard-addition, have been evaluated to ascertain the best procedure for simultaneous multi-element analysis of industrial soils by ICP-AES with CCD detection. A standard reference material, CRM143 from the Bureau Communautaire de Réference (BCR), has been analysed for Cd, Cr, Cu, Mn, Ni and Pb using the three different matrix interference correction procedures. All three procedures give comparable results which are in good agreement with the BCR values, except for Cr. The single-point standard addition procedure was chosen, on the basis of economy and ease of implementation, to correct for matrix interferences in the determination of Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sn and V in soil samples collected from an industrial site in England. Concentrations of some of the elements were found to vary greatly with sampling depth. For example, the concentration of Mn, determined using the atomic line at 279.920 nm, increased from 426 ± 3 g/g at a depth of 18–28 cm to 5996 ± 144 g/g at 60–85 cm. 相似文献
266.
The vibrational wavenumbers and the fundamental modes of 2,2′-biquinoline were obtained by density functional theory (DFT) with the B3LYP functional using the 6-31G(d,p) basis set. The calculated wavenumbers were scaled by a single factor of 0.965 to correct them for vibrational anharmonicity, but the force constants were overestimated. Normal coordinate analysis of the molecule was also carried out by using the force field of the quinoline molecule and the force field parameters of quinoline are shown to be transferable to 2,2′-biquinoline. The potential energy distribution associated with the normal modes is also given. The theoretical wavenumbers are found to be in good agreement with the experimental data. 相似文献
267.
本文报道了As(Ⅲ)-Cu(Ⅲ)两种离子对鲁米诺-MnO_4~-化学发光反应的协同抑制作用,据此拟定了测定微量As(Ⅲ)的化学发光新方法。该法灵敏度较高,检测限为6.8×10~(-9)g/ml As(Ⅲ),选择性也较好,同时线性范围宽(7.0×10~(-9)~3.0×10~(-6)g/ml),测定手续简便。应用本法测定工业废水中的As(Ⅲ),结果满意。 相似文献
268.
Giampiero Bettinetti Milena Sorrenti Laura Catenacci Franca Ferrari Silvia Rossi Ilaria Salvadeo Paolo Carraro 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):329-332
Triacetyl α-cyclodextrin, triacetyl β-cyclodextrin and triacetyl γ-cyclodextrin were tested as possible hydrophobic carriers
to prolong the release of hydrophilic teicoplanin (TCP). Physical–chemical characterization of individual components, drug-carrier
physical mixtures at 0.5, 0.67 and 0.75 mass fraction of carrier, and the respective interaction products by kneading or evaporative
crystallization under microwave irradiation was carried out using differential scanning calorimetry (DSC) and thermogravimetric
analysis (TGA). In vitro drug release in pH 7.4 phosphate buffer at 37 °C was determined by intrinsic dissolution rate (IDR)
measurements on non disintegrating compressed discs. Solid-state interactions of TCP with triacetyl α-cyclodextrin by evaporative
crystallization and kneading and with triacetyl β-cyclodextrin by evaporative crystallization (probably resulting in carrier
amorphization) were demonstrated. The role of carrier hydrophobicity, carrier mass fraction and preparation method of solid
drug-carrier combinations on solid-state drug-carrier interactions and slowing down of TCP release was assessed. Modulation
of drug release can be achieved using TCP-triacetyl γ-cyclodextrin combinations at 0.5 mass fraction of carrier. 相似文献
269.
硅杂环丁烷在有机硅化学中是一类非常重要的小分子环系化合物。由于硅杂环丁烷和环丁烷的环张力相似,因而显示出较高的反应活性。例如能与某些试剂作用,生成开环产物;在光解或热解条件下,产生具有Si=C结构的高活性中间体,可用以合成多种有机硅化合物。 相似文献
270.