Comparison of photodynamic efficacy of tetraarylporphyrin pegylated or encapsulated in liposomes: In vitro studies

Two photosensitizing systems: (1) tetrakis(4-hydroxyphenyl)porphyrin (p-THPP) encapsulated in sterically stabilized liposomes (SSL) and (2) p-THPP functionalized by covalent attachment of poly(ethylene glycol) (p-THPP–PEG₂₀₀₀) were studied in vitro. The dark and photo cytotoxicity of these systems were evaluated on two cell lines: HCT 116, a human colorectal carcinoma cell line, and DU 145, a prostate cancer cell line and compared with these determined for free p-THPP. It was demonstrated that both encapsulation in liposomes as well as attachment of PEG chain result in pronounced reduction of the dark cytotoxicity of the parent porphyrin. The liposomal formulation showed higher than p-THPP–PEG₂₀₀₀ photocytotoxicity towards both cell lines used in the studies.     

曙红-中性红荧光能量转移抑制法测定肝素

在pH 6.65的Britton-Robinson (B-R)缓冲溶液中, 酸性染料曙红(EY)与碱性染料中性红(NR)之间由于静电吸引而能够发生有效的能量转移, 使得能量受体NR荧光增强, 同时能量给体EY的荧光猝灭. 而肝素的加入对该荧光体系间的能量转移产生了明显的抑制作用, 随肝素量的增加EY荧光依次增强, 由此建立了测定微量肝素的新方法. 结果表明, 肝素在0.1～2.0 mg/L范围内与EY的荧光增强程度呈良好的线性关系. 方法检出限0.071 mg/L, 用于肝素钠注射液中肝素钠效价的测定, 6次平行测定相对标准偏差1.4%～3.6%, 回收率95.2%～105.3%.     

数值求解NDDEs系统的单支方法的非线性稳定性

该文探讨了单支方法关于一类中立型延迟微分方程（ＮＤＤＥｓ）系统的整体稳定性和渐近稳定性．在适当的条件下，获得了单支方法关于ＮＤＤＥｓ系统的一些新的非线性稳定性判据．     

北京谱仪中性径迹测量误差的确定

首先检查了北京谱仪(BES)桶部簇射计数器(BSC)对γ光子电磁簇射形成的中性径迹的沉积能量和空间位置的测量值;然后,利用辐射Bhabha事例修正了BSC的沉积能量及其误差δE;利用e⁺e^－→γγ(γ)过程确定了BSC测量中性径迹的空间位置的误差,这些研究结果可以减小用运动学拟合方法分析包含中性径迹的物理事例的系统误差,提高BES的测量精度.     

一类中立型脉冲时滞生物模型的正周期解(英文)

运用严格集压缩映射不动点定理,讨论得到了一类中立型脉冲时滞生物模型正周期解存在的充分条件.我们去掉了文[6,7,12-14]周期解存在的一些条件,推广了对应的结果.     

Oscillation for a second-order neutral differential equation with impulses

We consider a certain type of second-order neutral delay differential systems and we establish two results concerning the oscillation of solutions after the system undergoes controlled abrupt perturbations (called impulses). As a matter of fact, some particular non-impulsive cases of the system are oscillatory already. Thus, we are interested in finding adequate impulse controls under which our system remains oscillatory.     

Existence and Blowup of Solutions for Neutral Partial Integro-differential Equations with State-dependent Delay

In this paper, we study the existence and blowup of solutions for a neutral partial functional integro-differential equation with state-dependent delay in Banach space. The mild solutions are obtained by Sadovskii fixed point theorem under compactness condition for the resolvent operator, the theory of fractional power and α-norm are also used in the discussion since the nonlinear terms of the system involve spacial derivatives. The strong solutions are obtained under the lipschitz condition. In addition, based on the local existence result and a piecewise extended method, we achieve a blowup alternative result as well for the considered equation. Finally, an example is provided to illustrate the application of the obtained results.     

Solution of the Dipoles in Noncommutative Space with Minimal Length *

The single neutral spin-half particle with electric dipole moment and magnetic dipole moment moving in an external electromagnetic field is studied. The Aharonov-Casher effect and He-McKellar-Wilkens effect are emphatically discussed in noncommutative (NC) space with minimal length. The energy eigenvalues of the systems are obtained exactly in terms of the Jacobi polynomials. Additionally, a special case is discussed and the related energy spectra are plotted.