新型硬盘基板微晶玻璃的晶核剂研究

采用差热分析(DTA)、X-射线衍射分析(XRD)和扫描电镜(SEM)等分析手段研究了P2O5、TiO2、ZnF2作为晶核剂对Li2O-Al2O3-SiO2(LAS)系统微晶玻璃形核和晶化的影响。结果表明:P2O5晶核剂能获得小尺寸的晶粒,晶型为球形或多面体形,析晶的可控制性良好;TiO2晶核剂析晶温度较高,析晶强烈,形成条状细晶;ZnF2晶核剂能获得小尺寸球状晶粒,析晶温度较低,但对温度过于敏感。P2O5作为晶核剂可以获得理想小晶粒的透明微晶玻璃,从而适合于用作新型硬盘基板。     

Synthesis of Copper Oxide-Based Nanoformulations of Etoricoxib and Montelukast and Their Evaluation through Analgesic,Anti-Inflammatory,Anti-Pyretic,and Acute Toxicity Activities

Copper oxide nanoparticles (CuO NPs) were synthesized through the coprecipitation method and used as nanocarriers for etoricoxib (selective COX-2 inhibitor drug) and montelukast (leukotriene product inhibitor drug) in combination therapy. The CuO NPs, free drugs, and nanoformulations were investigated through UV/Vis spectroscopy, FTIR spectroscopy, XRD, SEM, and DLS. SEM imaging showed agglomerated nanorods of CuO NPs of about 87 nm size. The CE1, CE2, and CE6 nanoformulations were investigated through DLS, and their particle sizes were 271, 258, and 254 nm, respectively. The nanoformulations were evaluated through in vitro anti-inflammatory activity, in vivo anti-inflammatory activity, in vivo analgesic activity, in vivo anti-pyretic activity, and in vivo acute toxicity activity. In vivo activities were performed on albino mice. BSA denaturation was highly inhibited by CE1, CE2, and CE6 as compared to other nanoformulations in the in vitro anti-inflammatory activity. The in vivo bioactivities showed that low doses (5 mg/kg) of nanoformulations were more potent than high doses (10 and 20 mg/kg) of free drugs in the inhibition of pain, fever, and inflammation. Lastly, CE2 was more potent than that of other nanoformulations.     

两种新型的MRI造影剂 两种新型的MRI造影剂

用动物活体核磁共振Ｔ２分布像和Ｔ１加权像分别观测了超顺磁性氧化铁造影剂和电中性大分子锰配合物造影剂的实验结果。大白鼠肝部的活体测量结果显示,上述两种造影剂能分别显著地改变生物活体组织的Ｔ２和Ｔ１值。该实验结果对于磁共振造影剂的研制和人体的临床试验具有参考价值。     

Interruptin C,a Radioprotective Agent,Derived from Cyclosorus terminans Protect Normal Breast MCF-10A and Human Keratinocyte HaCaT Cells against Radiation-Induced Damage

Radiotherapy is a common method to treat cancers, with the goal of maximizing the dose to tumors while minimizing the dose to normal tissues. Radioprotectors can reduce the toxicity to normal tissues during radiotherapy. Several plant-derived compounds can function as radioprotectors by scavenging free radicals. We investigated the radioprotective activity of interruptin C from the fern Cyclosorus terminans. The molecular mechanism of interruptin C’s activity in X-ray-irradiated cells was evaluated. Superoxide dismutase activity was examined to investigate the antioxidant enzyme activity. Clonogenic cell survival was also investigated following radiation exposure. DNA damage and cell cycle progression were detected using micronuclei formation assays. DNA repair after irradiation was analyzed in a γH2AX assay. The levels of the proteins related to the radioprotective responses were analyzed by Western blotting. Interruptin C increased the antioxidant enzyme activity and significantly decreased the DNA damage by reducing the γH2AX foci and micronucleus formation in irradiated MCF-10A normal breast and HaCaT human keratinocyte cells. The apoptotic protein levels decreased, whereas the antiapoptotic protein levels increased. Interruptin C pretreatment increased the survival rate of irradiated MCF-10A and HaCaT cells. Moreover, the compound did not promote the survival of MDA-MB-231 and Hs578T breast cancer cells. Therefore, interruptin C may exert radioprotective activity without enhancing cancer cell proliferation.     

基于密度泛函理论研究碱性水溶液中乙内酰脲及其衍生物的结构及性质

乙内酰脲及其衍生物对多种金属离子具有良好的络合效果,是一种有望取代氰化物的绿色电镀络合剂.本文以密度泛函理论(DFT)方法对乙内酰脲及其衍生物的反应活性进行了研究.通过分子极性指数和极性表面积所占总面积百分比研究多种乙内酰脲衍生物在水中的溶解性,理论计算结果与文献报道的实验结果基本一致.通过原子电荷、表面静电势、原子对...     

水成膜泡沫灭火剂性能的实验室测定方法

水成膜泡沫灭火剂(aqueous film-form ingfoam,AFFF)是一类能够在烃类液体表面形成水膜的泡沫灭火剂[1-2]。在目前用于扑灭油类火灾的灭火剂中,AFFF由于其水成膜及泡沫的双重灭火作用具有最佳灭火效果。而且由于AFFF中绝大部分的组分是水,在国际范围的“淘汰哈龙行动”中作为哈     

Solid‐Phase Synthesis of the Aged‐Nonapeptide‐Nerve‐Agent Adduct of Butyrylcholinesterase as Reference Materials for Analytical Verification

Two pathways were developed and investigated for the synthesis of the ‘aged’‐nonapeptide nerve‐agent bioadduct of human butyrylcholinesterase (BuChE). Considering the fast ageing of nerve‐agent adducts of BuChE in patients and biomedical samples this target molecule is of paramount relevance for quantitative analysis with respect to the Chemical Weapons Convention. Two approaches using a precursor bearing a hydroxyl on its phosphonyl moiety and a benzyl protected precursor were considered. Several impurities were identified and circumvented during the optimization of the peptide synthesis step. The ‘aged’‐nonapeptide adduct was successfully synthesized by solid‐phase‐peptide‐synthesis (SPPS ).     

New Prospects toward the Synthesis of Difluoromethylated Phosphate Mimics

The difluoromethyl phosphonate motif plays a crucial role in the development of bioactive molecules as it is considered as a phosphate bioisoster. Since 2010, a renewal of interest to enlarge the panel of reactions to access these difluoromethylated phosphonate‐containing molecules has been witnessed. This Concept article charts the recent progress that has been made.