Synthesis, Crystal Structure and Inhibition of N-2-Thiophenesulfonyl-a-L-phenylalanine Ethyl Ester on K562 Cell Proliferation

The title compound N-2-thiophenesulfonyl-a-L-phenylalanine ethyl ester has been synthesized. Complete assignments were achieved by IR, MS, ^1H NMR and single-crystal X-ray diffraction analyses. Using MTT assay, the inhibitory rate of the title compound on K562 cells （chronic myeloid leukemic cells） was measured and the result of preliminary bioassay showed that the title compound possesses antiproliferation effects on K562 cells. In order to investigate the relationship between structure and activity of the target compound, we report its crystal structure and biological behavior in the present paper. Crystallographic data： C15H17NO4S2, Mr = 339.42, monoclinic, space group P21, flack = -0.15（12）, a = 5.7916（10）, b = 11.5078（19）, c = 12.924（2） A, β = 97.781（3）°, Z = 2, V = 853.4（2） A^3, De = 1.321 g/cm^3, F（000） = 356, -7≤h≤7, -10≤k≤14, -15 ≤ l≤15, R = 0.0628, wR = 0.1540 and μ（MoKa） = 0.327 mm^-1. The molecule comprises a benzene and a thiofuran rings, and the intramolecular N（1）-H（1A）…O（1） makes a five-membered ring of O（1）--C（6）-C（5）--N（1）--H（1A）.     

双[N,O]配体合镍催化剂/MAO催化MMA聚合的研究

合成了双[水杨醛(对硝基苯)亚胺]合镍催化剂A和双[水杨醛(对甲氧基苯)亚胺]合镍催化剂B.该两种双[N,O]配体合镍配合物/MAO催化体系能有效地催化极性单体甲基丙烯酸甲酯(MMA)聚合,催化活性可高达105gPMMA/(molNi.h).其中配体对位含有硝基吸电子(共轭)效应的催化剂A/MAO体系有相对较高的聚合反应热稳定性,温度达50℃时仍具有高催化活性.配体对位含有甲氧基推电子(共轭)效应的催化剂B/MAO则在30℃和Al/Ni摩尔比为600时表现出最高的催化活性.催化剂B/MAO体系催化得到PMMA的链序列结构以间规为主(含高达73.2%rr三元组),具有较高的玻璃化转变温度(Tg=106.4℃).     

以环糊精为模板剂制备不同粒径CeO2纳米粒子

稀土化合物由于具有许多特殊的性质而引起了世界各国科学家的高度重视.CeO2是一种廉价而用途很广的材料,如用于发光材料、催化剂、电子陶瓷、玻璃的抛光等.尤其,CeO2因具有特殊的储氧和释氧能力而作为重要的助催化剂在汽车尾气催化净化中得到广泛应用[1,2].大量文献研究表明,制     

Synthesis and structure characterization of a novel series of N-alkylphthalimidylaminocarbonylmethoxylcalix [4] arenes

A novel series of N-alkylphthalimidylaminocarbonylmethoxylcalix[4]arenes with the reaction between 4-(N-bromoacetyla- mino)-phthalimide derivatives and calix[4]arene has been synthesized and structurally characterized by IR,~1HNMR and MS.From their analysis data,it was found that compounds 7a-7d adopted a cone conformation.     

二安替比林基-4-羟基苯基甲烷及其与铬(Ⅵ)显色反应的研究

合成了二安替比林基-4-羟基苯基甲烷(DApHM),研究了它与铬(Ⅵ)的显色反应,建立了两个测定铬(Ⅵ)的新体系.在Mn(Ⅱ)和磷酸存在下,DApHM与 Cr(Ⅵ)反应生成橙红色产物,λ_max为435nm.CTMAB和Tween-80对该体系有明显增敏效果,其中CTMAB-DApHM-Cr(Ⅵ)体系ε为1.0 ×10~6;Tween-80-DApHM-Cr(Ⅵ)体系ε为6.9×10~5.Cr(Ⅵ)量在0.1～0.7μg/25mL间符合比尔定律.用于电镀废液和自来水中Cr(Ⅵ)的测定,结果满意.     

浙江长兴煤山二叠-三叠系界线剖面磁性地层特征

煤山二叠-三叠系剖面(31.1°N,119.7°E)包括晚二叠世长兴组和早三叠世青龙组,厚约60m,共采集古地磁样品111块。测量结果表明该剖面存在6个正、反极性带,它们都属于Illawarra混合极性间隔。二叠-三叠系界线位于正极性带V底界以上1.2(2.7)m,实验证明,长兴组下段岩石中磁性矿物主要为针铁矿、赤铁矿和含钛磁铁矿;上段岩石中以含钛磁铁矿和磁铁矿为主,部分岩石也含较多的针铁矿。青龙组灰岩和泥灰岩中主要含磁铁矿和赤铁矿。根据磁性稳定样品结果,获得三叠纪初期古地磁极位于50.7°N,230.3°E,采样地区古纬度为12.3°N。     

N-(6-甲基-2-亚甲基吡啶)-( )-樟脑亚胺体系的不对称烷基化反应

目前,不对称合成光学活性化合物取得了较大进展,不对称合成α-氨基酸、β-氨基醇、α-取代苄胺的报道很多。但是,不对称合成生物碱类物质——α-取代氨甲基吡啶类化合物还未见文献报道,而此类化合物有潜在的应用前景。为此,我们以( )-樟脑为手性试剂     

流动注射-荧光光纤传感器测定盐酸

将3－羟基－4‘-N,N-二甲氨基黄酮甲基丙烯酸酯与甲基丙烯酸甲酯和丙烯酸丁酯共聚，制备了含荧光基团的高聚物（PFMB），以PFMB为敏感膜研制了一种荧光猝灭型的盐酸光纤传感器。在Fe(Ⅲ）存在下，猝灭效率大大增加，猝灭机制主要包括Fe(Ⅲ）与Cl^-形成络合物的初级内滤效应和该络合物与PFMB形成非荧光复合物两种作用。该传感器可直接用于0．1－6．0mol/L盐酸的测量。与流动注射联用可测量0．1－12．0mol/L的盐酸。传感器具有良好的重现性和可逆性，响应和恢复时间均小于40s，且有较长的使用寿命。     

A New Triterpenoid from "Gualou-xiebai-baijiu-tang" Consisting of Fructus trichosanthis and Bulbus allii mtacrostemi

A new triterpenoid saponin was isolated by bioactivity-guided isolation from "Gualou-xiebai-baijiu-tang" consisting ofFructus trichosanthisi and Bulbus allii macrostemi. Its structure was determined as 3-O-β-D-galactopyranosyl-hederagenin 28-O-β-D-xylopyranosyl (1→6)- β-D-galactopyranosyl ester by means of chemical evidences and spectral analysis.     

Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists

A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin Ⅱ AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonism of angiotensin Ⅱ, induced contraction in the rabbit thoracic aortic ring and the results showed that compounds 9a, 9g and 9j exhibited potent antagonistic activity of AT1 receptor.