Simultaneous separation and identification of hashish constituents by coupled liquid chromatography-mass spectrometry (HPLC-MS)

Summary This paper reports the use of liquid chromatography for the separation and determination of the major cannabinoids extracted from hashish samples. The direct coupling to the mass spectrometer enables the selective identification both of neutral and acidic cannabinoids. The developed method does not require any preliminary derivatization and should, therefore, be of interest in forensic analysis for simple and unequivocal determination of hashish constituents.Part of this work was presented at the 2nd Italian-Spanish Joint Meeting of Medicinal Chemistry, 30 August–3 September 1995, Ferrara, Italy.     

舒兰褐煤树脂组分中某些分离物的化学研究

我国褐煤资源丰富 ,分布于云南、吉林、黑龙江、山东和内蒙古等地。褐煤除作燃料和腐植肥料外 ,还应用于轻化工和机械工业 ,如从褐煤制取褐煤蜡。褐煤蜡中含有较多的树脂物质 ,影响了褐煤蜡的质量 ,因此通常褐煤蜡树脂作为废弃物脱除 ,以提高褐煤蜡的质量。褐煤蜡的化学组成为纯蜡和树脂 ,前者为高碳脂肪酸和脂肪醇的酯类、游离脂肪酸和脂肪醇 ,以及烃类物等 ;后者则以萜类为主 ,并含有甾醇、羟基酸和烃化合物[1～ 5] 。 1982年唐运千等采用红外光谱和氢核磁共振谱检定 ,褐煤树脂中含有 β 谷甾醇 ;柱层析和薄层层析检出雌二醇和雌酚酮[2 ] …     

用铜（Ⅱ）—L—精氨酸配体交换薄层色谱拆分氨基酸对映体

报道了一种新的配体交换薄层色谱拆分氨基酸对映体的方法。以醋酸铜－Ｌ－精氨酸的络合物为配体交换剂，用浸渍的方法吸附在硅胶薄层板上，制成配体交换薄层，用ＰＲＩＳＭＡ优化法选择出展开剂的最佳组成为：甲醇／乙腈／四氢呋喃／水＝８０：８．２：５．８：６，在此色谱条件下，十对氨基酸对映体得到良好的分离，Ｄ－和Ｌ－氨基酸的相对比移值在１．０９－２．４０之间。文中对配体交换薄层的制备方法，样品的分子结构及色谱行为     

高效毛细管电泳的电导检测和紫外光度检测研究

本文自制商效毛细管电泳装置.研究了毛细管区带电泳电导检测和毛细管胶束电动色谱紫外光度检测。在电导检测中,制作铂丝微电导池,并由用电池隔膜制作的导电接口连接电泳毛细管和电导池,高压被有效隔离,实现柱后电导检测,用内径200μm、长70cm(到接口)石英毛细管在10kV电压下分离检测Li~-、Na~-、K~-。在电动色谱中将高效液相色谱仪与高压电源组成电泳装置,用内径100μm,长50cm(到检测器)石英毛细管和SDS胶束溶液在14kV电压下分离检测电中性化合物。     

用毛细管电泳法对某些药物的分离试验

本文采用毛细管电泳法,以50μm内径,45cm长的弹性石英毛细管作为分离管,选用磷酸盐-硼酸盐-十二烷基硫酸钠缓冲溶液体系,在柱254nm紫外检测器,在不同的电泳电压下,对水溶性维生素,磺胺类药物、头孢菌素抗生素,解热镇痛药物有效成份进行了分析,取得较满意的结果。     

Chiral recognition in the resolution of enantiomers by GLC

Summary Chiral recognition of many enantiomeric solutes by a chiral amide stationary phase is based mainly on hydrogen bonding. A chiral-recognition-factor CHI is proposed, given by the difference of the enthalpy change in the enantiomer discrimination, standardized with respect to the specific interaction of the solutes with the diamide core of the stationary phase. The r?le of the entropy part is also discussed. By extrapolation of the retention behaviour to elevated temperature, peak inversion of enantiomers is predicted. Presented at the 15th International Symposium on Chromatography, Nürnberg, October 1984