Dual-beam laser analyzer for inhomogeneities in active regions of multielement photodetectors

We describe equipment and a procedure for measuring inhomogeneities in active regions of solar cells, photoelectric transducers, and multielement photodetectors, based on a computer-controlled dual-beam laser scanner including a Pentium III personal computer, an HP-34401A digital multimeter with RS-232 serial interface;, a platform movable along the Y coordinate with the sample multielement photodetector to be tested and a microprobe device for picking up the photocurrents, an optical head with laser photodiodes in the visible (λ₁ = 0.68 μm) and IR (λ₂ = 0.82 μm) ranges scanning along the X coordinate, and a control unit for focusing the laser beams λ₁, λ₂, stabilizing the laser radiation power, and controlling the step motors for the X,Y coordinates. The equipment and procedure enable laser scanning of sample multielement photodetectors, with external dimensions 10 × 10 μm2 to 150 × 150 mm², along the X, Y coordinates at a maximum rate of 100 mm/sec; minimum radiation power of the laser diodes, 10 mW; range of laser beam diameters, 2–50 μm; range of scanning steps along the X, Y coordinates, 5–100 μm; current sensitivity 1·10⁻⁸ A, voltage sensitivity 1·10⁻⁷ V; measurement and analysis accuracy at least 0.5%; storage of color plots of the inhomogeneities in the active regions of the multielement photodetectors on the hard disk of the personal computer, with output of analysis results to a monitor and color printer, 32 color gradations. Software written in Delphi 7.0. __________ Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 73, No. 2, pp. 277–280, March–April, 2006.     

Electronic concentration of negatively-charged molecules on a microfabricated biochip

Various conditions leading to successful electronic concentration of negatively-charged molecules, notably oligonucleotides, on a microfabricated biochip have been studied. Tests on two chip designs have been performed. In the first generation biochip, which consisted of 12 electrodes 5 mm apart, fluorescent molecules were attracted to a positively-biased electrode leading to electronic concentration. In the second generation biochip, which consisted of eight electrodes 250 μm apart, much faster concentration rates were observed due to reduction in electrode spacing. These results are significant to design a pathogen detection biochip based on DNA hybridization assisted by electronic concentration.     

Investigating the competitive assumption of Multinomial Logit models of brand choice by nonparametric modeling

Summary  The Multinomial Logit (MNL) model is still the only viable option to study nonlinear responsiveness of utility to covariates nonparametrically. This research investigates whether MNL structure of inter-brand competition is a reasonable assumption, so that when the utility function is estimated nonparametrically, the IIA assumption does not bias the result. For this purpose, the authors compare the performance of two comparable nonparametric choice models that differ in one aspect: one assumes MNL competitive structure and the other infers the pattern of brands? competition nonparametrically from data.     

Ⅱ类热成像光机扫描技术的发展

根据武器系统的要求，缩小了军用热像仪扫描器的尺寸并减轻了其重量，指出改善空间分辨率是提高Ⅱ类热像仪性能的主要技术手段。认为采用限制孔径望远镜和变形光学系统是改善空间分辨率的简便而又经济的途径。     

Allergen diagnosis microarray with high-density immobilization capacity using diamond-like carbon-coated chips for profiling allergen-specific IgE and other immunoglobulins

The diagnosis of antibody-mediated allergic disorders is based on clinical findings, skin prick tests and detection of allergen-specific IgE in serum. Here, we present a new microarray technique of high-density antigen immobilization using carboxylated arms on the surface of a diamond-like carbon (DLC)-coated chip. High immobilization capacity of antigen on DLC chip at (0.94–7.82) × 10⁹ molecules mm⁻² allowed the analysis of allergen-specific immunoglobulins against not only purified proteins but also natural allergen extracts with wide assay dynamic range. The higher sensitivity of the allergen-specific IgE detection on DLC chip was observed for comparison with the UniCAP system: the DLC chip allowed lowering the limit of dilution rate in UniCAP system to further dilution at 4–8-fold. High correlations (ρ > 0.9–0.85) of allergen-specific IgE values determined by the DLC chip and UniCAP were found in most of 20 different allergens tested. The DLC chip was useful to determine allergen-induced antibodies of IgA, IgG, IgG1, and IgG4 in sera, apart from IgE, as well as secretory IgA in saliva against the same series of allergens on the chip in a minimal amount (1–2 μL) of sample.     

A very fast algorithm for matrix factorization

We present a very fast algorithm for general matrix factorization of a data matrix for use in the statistical analysis of high-dimensional data via latent factors. Such data are prevalent across many application areas and generate an ever-increasing demand for methods of dimension reduction in order to undertake the statistical analysis of interest. Our algorithm uses a gradient-based approach which can be used with an arbitrary loss function provided the latter is differentiable. The speed and effectiveness of our algorithm for dimension reduction is demonstrated in the context of supervised classification of some real high-dimensional data sets from the bioinformatics literature.     

一种8行任意扫描的电光扫瞄器

 针对激光的快速智能扫描,综合利用晶体的双折射效应和电光效应,提出一种电控集成8行任意扫瞄的高速光扫描方案。主要由三级数字电光偏转器和8×1的周期性极化电光棱镜组构成,其中3个电光快门和3块双折射晶体构成三级数字偏转器,通过半波电压的控制实现行位置的转换,一定数目的周期性极化电光棱镜级联组成单行偏转器,通过控制电压进行单行扫描,根据电场施加方式可实现数字型或者连续型扫描。利用梯形结构的电光棱镜组设计了最大电压为5.822 kV时,扫描视场为17.256°的可通过联机控制进行任意行扫描的高速激光扫描器。     

多点分段单步校正法在接触式图像传感器扫描仪上的实现

提出了一种接触式图像传感器(CIS)扫描仪非均匀校正的新方法,能够快速高效地完成对CIS扫描仪彩色图像的非均匀校正,消除了CIS的颜色差异。采用多点分段单步法进行标定,采用现场可编程门阵列实现校正,并最终得到颜色均匀的彩色图像。对于分辨率高达1200dpi的CIS扫描仪,采集一次样板纸完成全部颜色空间的分段标定,图像传输的同时完成校正,校正过程仅耗时0.125μs。实际应用效果显示校正后R,G,B三个通道的像素误差控制在5个像素以内,相比校正前图像均匀性提升10倍左右,比传统两点法提升3倍左右,且明显改善图像颜色突变、暗淡以及随机条纹等问题。