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91.
An anti-tumor drug doxorubicin was encapsulated in micelles of poly(ethylene glycol)-b-poly(2,2-dihydroxyl-methyl propylene carbonate)(PEG-b-PDHPC) diblock copolymers.The morphology of both blank micelles and drug loaded micelles was characterized by TEM.The in vitro drug release profiles of micelles were investigated.The cytotoxicity of the micelles was evaluated by incubating with Hela tumor cells and 3T3 fibroblasts.The drug loaded micelles were co-cultured with HepG2 cells to evaluate the in vitro anti-tumor efficacies.The results showed that the mean sizes of both micelles with different copolymer compositions increased after being loaded with drugs.The drug release rate of PEG45-b-PDHPC34 micelles was faster than that of mPEG114-b-PDHPC26,micelles.Both of the two block copolymers were non-toxic.The confocal laser scanning microscopy and flow cytometry results showed that both the drug loaded micelles could be internalized efficiently in HepG2 cells.The PEG45-b-PDHPC34 micelles exhibited higher anti-tumor activity comparing to mPEG114-b-PDHPC26 micelles. 相似文献
92.
在选择性溶剂中进行RAFT聚合一步合成核交联的纳米胶束 总被引:1,自引:0,他引:1
在选择性溶剂中,大分子RAFT试剂PSSC(S)Ph和AIBN引发剂存在下,进行4乙烯基吡啶(4VP)和二乙烯基苯(DVB)的RAFT聚合,一步合成了稳定的平头型胶束.大分子RAFT试剂是通过以二硫代苯甲酸2(乙氧甲酰基)2丙酯为链转移剂,AIBN为引发剂进行苯乙烯的RAFT聚合反应获得的.嵌段共聚,胶束化和交联反应一锅完成.1HNMR,DLLS,SLLS,TEM和AFM等验证了产品的组成与结构. 相似文献
93.
This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic poly(ε-caprolactone) (PCL). A series of AB2 triarm star-shaped copolymers with different molecular-weights for the PCL block were successfully synthesized by a three-step procedure. α-Methoxy-ω-epoxy-poly(ethylene oxide) (PEO-epoxide) was first synthesized by the nucleophilic substitution of α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) on epichlorohydrin. In a second step, the α-methoxy-ω,ω′-dihydroxy-poly(ethylene oxide) (PEO(OH)2) macroinitiator was prepared by the selective hydrolysis of the ω-epoxy end-group of the PEO-epoxide chain. Finally, PEO(OH)2 was used as a macroinitiator for the ring-opening polymerization (ROP) of ε-caprolactone (εCL) catalyzed by tin octoaote (Sn(Oct)2). PEO-epoxide, PEO(OH)2 and the AB2 triarm star-shaped copolymers were assessed by 1H NMR spectroscopy, size exclusion chromatography (SEC) and MALDI-TOF. The behavior of the AB2 triarm star-shaped copolymer in aqueous solution was studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). 相似文献
94.
Madhuri Mandal Debabrata Pal Kalyan Mandal 《Colloids and surfaces. A, Physicochemical and engineering aspects》2009,348(1-3):35-38
Snow-ball flower like Ni nanoparticles have been synthesized using negatively charged micelles. Negatively charged micelles incorporate the Ni+2 onto its head group by electrostatic attraction and again a surfactant layer is arranged on positively charged Ni and thus in a repetitive way layer-by-layer a snow-ball flower like structure is formed. After reduction of Ni+2 to Ni atom by sodium borohydride and hydrated hydrazine the Ni clusters (3 nm) are formed and confined in micelles in snow-ball flower like pattern. The sizes of these nanoflowers are of 30 nm order. The particles are superparamagnetic in nature with blocking temperature about 117 K. 相似文献
95.
阳离子Gemini表面活性剂3,5-双(亚甲基十八烷基二甲基溴化铵)-1,2,4-三氮唑胶束对酯碱性水解的影响 总被引:1,自引:0,他引:1
在25℃条件下,研究了乙酸乙酯和乙酸戊酯在阳离子Gemini表面活性剂3,5—双(亚甲基十八烷基二甲基溴化铵)—1,2,4—三氮唑(简称18—triazole—18)胶束中的碱性水解反应。实验结果表明.在一定的表面活性剂浓度范围内,乙酸乙酯和乙酸戊酯在Gemini表面活性剂18—triazole—18胶束溶液中的碱性水解反应速率随表面活性剂浓度的增加呈上升趋势,达到一最大值后,随着浓度的增加呈下降趋势。实验结果还表明,18—triazole—18对乙酸乙酯碱性水解的影响较对乙酸戊酯碱性水解的影响大。随着底物疏水性的增加,乙酸乙酯和乙酸戊酯的碱性水解速率在18—triazole—18胶束中表观反应速率常数最大值分别为无表面活性剂时的5.5倍和1.1倍。 相似文献
96.
采用丁二酮室温光猝灭法研究了胶束介质中丁二酮的增溶位点,通过研究4种不同荷电和不同亲水亲脂性的光猝灭剂以及盐效应等对Stern-Volmer常数的影响,表明了二酮在SDS、CTAB的胶束中是增溶在胶团的栏栅并靠近离子头基一侧和头基/水界面附近,而在CTAB胶束中更加趋向于胶团外部头基附近. 相似文献
97.
We synthesized the GSH/pH responsive amphiphilic random polycarbonate poly(MN-co-MSS) with the disulfide and tertiary amine groups situated on the backbone. The poly(MN-co-MSS) was therefore a promising candidate for GSH/pH-sensitive drug carriers. 相似文献
98.
Marcela?A.?Morini Paula?V.?Messina Pablo?C.?SchulzEmail author 《Colloid and polymer science》2005,283(11):1206-1218
The effect of NaCl and HCl on two non-ionic surfactant micelles was studied using several techniques, including conductivity
and ion-selective electrodes. Both surfactants exhibit opposite behaviour. When Tween 20 is titrated with HCl the conductivity
notably increases in comparison with water, whereas that of Triton X-100 solutions do not change with respect to water until
a certain HCl concentration is reached, when it increases. The hydrogen ion activity is lower in Triton X-100 solutions and
higher in Tween 20 solutions than in pure water. Chloride ion activity is higher in Tween 20 solutions than in water, whereas
in Triton X-100 the activity does not significantly differ from that in water. The activity of sodium ion is lower in Tween
20 solutions than in water, whereas that in Triton X-100 solutions does not differ from the titration of water. These phenomena
are explained by the changes in conformation of the non-ionic headgroups, which capture water, and in some cases ions, modifying
the activity of ions in the intermicellar solution. 相似文献
99.
The anionic dye 8-anilino-1-napthalensulfonic acid ammonium salt, or ANS, was used as a fluorescent probe to investigate the behaviour of dye-surfactant interactions in aqueous solutions of Triton X-100 and the Brij and polyoxyethylene tridecyl ether (POE TDE) series of polyoxyethylene non-ionic surfactants. The fluorescence behaviour of the dye with the non-ionic surfactants was examined in micellar media. The concentration of surfactant was kept well above the cmc to investigate the interaction of the dye with surfactant micelles. In this investigation, the relative fluorescence enhancements, binding constants of the dye to the surfactant micelles and aggregation numbers of the micelles were determined, from the analysis of spectroscopic data. 相似文献
100.
Hydrophobic interaction chromatography (HIC) of proteins using a phenyl column has been performed in the presence of various surfactants with micellar and submicellar concentration ranges. Most surfactants were effective for a decrease in the retention of proteins in both concentration ranges. However, the use of anionic cholate derivatives increased the retention of the proteins with high isoelectric point, such as lysozyme, cytochrome c, and trypsin, in submicellar concentration range, and then decreased it above the critical micellar concentration, while the retention of the other proteins was monotonously decreased. The results of frontal chromatographic analysis of the surfactant and capillary electrophoresis for the proteins in the presence of surfactant show that in the submicellar concentration range, cholate derivatives allowed to be adsorbed on the stationary phase, while they exhibited no interactions with the proteins. Thus, it appeared that the increase in the retention of basic proteins was due to the electrostatic attraction between the proteins and cholate-modified stationary phase. We have applied the unique property of cholate to the separation of ovalbumin and lysozyme in egg white sample using hydrophobic chromatography. 相似文献