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11.
12.
Xiaojing Lü Gang Chen Zhanlin Li Yuhong Zhang Zaiying Wang Weiwei Rong Yuehu Pei Huaqi Pan Huiming Hua Jiao Bai 《Helvetica chimica acta》2014,97(9):1289-1294
One new and three known spiro‐dioxynaphthalene compounds, related to palmarumycins, were isolated from the extracts of fungus Lasiodiplodia pseudotheobromae XSZ‐3. Their structures were established by spectroscopic methods (1D‐ and 2D‐NMR, HR‐ESI‐MS, etc.). The absolute configuration of 1 was determined by comparison of quantum‐chemical TDDFT (time‐dependent density‐functional theory) calculated and experimental ECD (electronic circular dichroism) spectra. The cytotoxic activities of 1 – 4 against HL‐60 cell line were evaluated by trypan blue‐staining assay. 相似文献
13.
Wenqing Yin Yongcheng Lin Zhigang She L. L. P. Vrijmoed E. B. Gareth Jones 《Chemistry of Natural Compounds》2008,44(1):3-5
A new metabolite xyloketal H (1), was isolated from mangrove fungus Xylaria sp. (No.2508) obtained from the South China Sea. By spectroscopic analyses, primarily 2D NMR methods and X-ray diffraction
experiments, its structure was elucidated.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 5–6, January–February, 2008. 相似文献
14.
Chunyuan Li Weijiang Ding Zhigang She Yongcheng Lin 《Chemistry of Natural Compounds》2008,44(2):163-165
A new biphenyl derivative 3,5′-dihydroxy-4′,5-dimethoxy-2′-methyl-[1,1′-biphenyl]-2-carboxylic acid methyl ester (1), was isolated from the culture broth of a fungus isolated from the rhizosphere soil of mangrove root on the South China
Sea. The structure of 1 was determined by comprehensive spectroscopic methods, primarily 2D NMR techniques.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 128–129, March–April, 2008. 相似文献
15.
Xuan Ma Xu-Hua Nong Zhe Ren Jie Wang Xiao Liang Lu Wang Shu-Hua Qi 《Tetrahedron letters》2017,58(12):1151-1155
A new cyclic pentapeptide and three new linear peptides, namely, aspergillipeptides D–G (1–4), were isolated from a culture broth of marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were confirmed by Marfey’s method. Compounds 1 and 2 showed evident antiviral activity against herpes simplex virus type 1 (HSV-1) with IC50 values of 9.5 and 19.8 µM under their non-cytotoxic concentrations against a Vero cell line, respectively, and 1 also had antiviral activity against acyclovir-resistant clinical isolates of HSV-1. 相似文献
16.
Nine new fungal metabolites, penicisochromans A-E, penicipyrone, penicipyranone, peniciphenol, and penicisoquinoline, were isolated from the sea fan-derived fungus Penicillium sp. PSU-F40 together with five known compounds. Their structures were determined by spectroscopic analysis. Their antibacterial activity against the standard Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus was evaluated. 相似文献
17.
Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation
Jun-Feng Wang Xiaochu Qin Fu-Quan Xu Tianyu Zhang Shengrong Liao Xiuping Lin 《Natural product research》2015,29(18):1761-1765
Fifteen compounds, including two tetramic acid derivatives, penicillenol A1 (1) and penicillenol A2 (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A–F (3–8), together with six phenolic bisabolane sesquiterpenoids (9–14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3–5, 7 and 8 showed potent COX-1 inhibitory activity with IC50 values of 5.3, 16.2, 30.2, 41.0 and 56.8 μM, respectively. Meanwhile, compounds 3–8 showed potent COX-2 inhibitory activity with IC50 values of 3.1, 5.6, 3.0, 5.1, 3.2 and 3.7 μM, respectively. In addition, compound 1 exhibited antituberculosis activity with 96.1% inhibition at concentration of 10 μM. 相似文献
18.
A New Cyclic Peptide and a New Steroid from the Fungus Penicillium sp. GD6 Isolated from the Mangrove Bruguiera gymnorrhiza
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Zhen‐Fang Zhou Xiao‐Hong Yang Hai‐Li Liu Yu‐Cheng Gu Bo‐Ping Ye Yue‐Wei Guo 《Helvetica chimica acta》2014,97(11):1564-1570
A rare new cyclic tetrapeptide, 5,5′‐epoxy‐MKN‐349A ( 1 ), featured by a MKN‐349A ( 5 ) skeleton and containing an uncommon ether bridge between C(5) and C(5′), and a new steroid, named 11‐O‐acetyl‐NGA0187 ( 2 ), together with two known steroids, 3 and 4 , were isolated from an endophytic fungus Penicillium sp. GD6 associated with the Chinese mangrove Bruguiera gymnorrhiza. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses and by comparison with the data of related compounds reported in literature. Neither of the compounds 3 and 4 , isolated in this study, showed obvious bioactivities in the antibacterial bioassay experiments. 相似文献
19.
Jianping Zhang Yifan Wu Bochuan Yuan Dong Liu Kui Zhu Jian Huang Peter Proksch Wenhan Lin 《Tetrahedron》2019,75(14):2193-2205
Bioinformatics analysis of the synthetic gene clusters in association with the qRT-PCR detection led to speculate a marine derived fungus, Penicillium brasilianum WZXY-m122-9, to be potential to produce meroterpenoids. Chromatographic separation of the EtOAc extract of this fungal strain on a large-scale fermentation resulted in the isolation of six new DMOA-related meroterpenoids, namely brasilianoids G?L (1–6), together with nine known meroterpenes. Their structures were determined by extensive analyses of spectroscopic data, including the X-ray diffraction and the ECD data for configurational assignment. Brasilianoid G is characterized by the presence of an unprecedented scaffold bearing a 6/6/5/5/5 pentacyclic nucleus, while brasilianoid K possessing a 7/6/6/6/5 pentacyclic system is uncommonly found from nature. The biogenetic relationship among the isolated compounds was postulated based on the comparative analyses of gene clusters. Brasilianoid L (6), austinol (12), and dehydroaustin (14) exhibited significant inhibition against bacteria invasion into host cells, that was suggested to be mediated by preventing the polymerization of actin in the host cells. 相似文献
20.
Hou-Jin Li Cai-Wu Jiang Meng-Yang Xu Dan-Feng Yan Jun Xu Wen-Jian Lan 《Tetrahedron letters》2019,60(34):150953
Three sesquiterpenoids pseudapenes A–C (1–3) were isolated from the marine-derived fungus Pseudallescheria apiosperma F52-1. Pseudapene A (1) has an unprecedented 2-methyl-5-methylene-3-(2-methylbut-2-ene)-dicyclo(3, 3, 0)-octane carbon skeleton and pseudapenes B (2) and C (3) possess an unique 2-methyl-4-methylene-2-(2-methylpent-2-ene)-dicyclo(3, 2, 0)-heptane chemical scaffold. Their structures were determined by use of MS and NMR spectroscopic data, and ECD, optical rotation and 13C NMR calculations. 相似文献