排序方式: 共有18条查询结果,搜索用时 24 毫秒
11.
12.
13.
14.
Katharina Baumann Dr. Danuta Kowalczyk Tobias Gutjahr Dipl.‐Chem. Markus Pieczyk Claire Jones Dr. Martin K. Wild Priv.‐Doz. Dr. Dietmar Vestweber Prof. Dr. Horst Kunz Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(17):3174-3178
Total synthesis through block glycosylation and selective chemical O‐sulfation of tyrosine residues yielded the glycopeptide recognition domain A (X=SO3?) of the P‐selectin glycoprotein ligand 1, in which the terminal sialic acid of the complex hexasaccharide side chain was replaced by (S)‐cyclohexyl lactic acid. In binding assays the O‐sulfated structure A showed high affinity towards P‐selectin, the non‐sulfated towards E‐selectin.
15.
FP Binder K Lemme RC Preston B Ernst 《Angewandte Chemie (International ed. in English)》2012,51(29):7327-7331
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture). 相似文献
16.
17.
18.