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A simple NMR spectroscopic method is described for the assay of busulfan in tablets. Methenamine is used as the internal standard and chloroform-d as the solvent. The mean recovery value for the drug from standard mixtures was 99.3 ± 0.182% w/w (n = 5) by the NMR method and 99.2% (n = 2) by the official method. The mean content of busulfan in commercial tablet samples was 99.4 ± 0.16 (range 99.1 – 99.6)% w/w (CV = 0.16%, n = 10) by the NMR method and 99.5 ± 0.17 (range 99.2 – 99.8)% w/w (CV = 0.17%, n = 10) by the official method. 相似文献
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单扫描示波极谱法测定磷酸氯喹 总被引:1,自引:0,他引:1
建立了极谱测定磷酸氯喹的方法。在4.0×10-2mol LNH3·H2O NH4Cl(pH9.5)支持电解质中,磷酸氯喹极谱还原波的峰电位Ep为-1.61V(vs.SCE),其二阶导数峰峰电流ip″与磷酸氯喹浓度在1.0×10-8mol L~1.0×10-6mol L和1.0×10-6mol L~1.0×10-4mol L范围内呈线性关系。10次测量1.0×10-6mol L磷酸氯喹还原波二阶导数峰峰电流,相对标准偏差RSD为0.92%。该方法用于片剂中磷酸氯喹的测定。 相似文献
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F. Belal 《Chromatographia》1988,25(1):61-63
Summary A reversed-phase, High-performance Liquid chromatographic method for the simultaneous determination of phenazopyridine and
nitrofurantoin in tablets is described. An aminopropyl-silica (APS-Hypensil) 5μm column and a mobile phase consisting of Methanol:H2O: 0.05M sodium dihydrogen phosphate (50∶45∶5) were used. Calibration curves were linear over the concentration range 2–20μg/ml,
with minimum detectability of 10ng/ml for both drugs. The method was applied to tablets containing the two species and the
results obtained were compared to those given with a published method. 相似文献
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本文介绍了应用空气-乙炔火焰原子吸收法测定富血素糖片中铁的含量。用聚四氟乙烯高压消化罐溶解样品,消除了某些干扰因素。此法简便、快速,所得的分析结果与标准方法基本一致,其回收率在98%-102%之间,相对标准偏差(RSD)≤1.0%,结果令人满意。 相似文献
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Perioli L Ambrogi V Pagano C Massetti E Rossi C 《Colloids and surfaces. B, Biointerfaces》2011,84(2):413-420
The aim of this work was the realization of new formulations for vaginal application to improve the pharmacological effect of benzydamine, displaying both anti-inflammatory and antiseptic activities. For this reasons, this drug was formulated in solid dispersions, by using the mucoadhesive polymers HPMC and/or Carbopol(?), then compressed. Tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion and in vitro release. Kinetics, responsible for drug delivery, was investigated as well. Tablets prepared by using only HPMC showed the best results in terms of swelling and mucoadhesion (time and force) together with prolonged and complete drug release, by diffusive mechanism, through gelled layer. Despite the good mucoadhesive properties, Carbopol(?) does not represent a good excipient because, after the contact with water, it generates a spongy gel layer, not homogeneous, stiff, brittle and with breaking tendency when highly swelled. This kind of gel does not guarantee a linear drug release and could provoke discomfort because of fragment release. HPMC mucoadhesive tablets could be a proper delivery system for benzydamine administration representing a good alternative to traditional dosage forms for vaginal topical therapy. 相似文献
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This article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-derived designer drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into consideration articles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thin layer). We describe several types of chiral derivatization reagent, mobile-phase additive and chiral stationary phase commonly used in the chromatographic methods. Tables summarize basic information about conditions (e.g., type of column and mobile phase), detection mode and reference data for each procedure. 相似文献