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K. C. Nicolaou Jim Li 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2001,113(22):4394-4398
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(26):7552-7556
In total and formal syntheses of dictyodendrins B, C, E, and F, the key step involved the direct construction of the pyrrolo[2,3‐c ]carbazole core by the gold‐catalyzed annulation of a conjugated diyne with a pyrrole to form three bonds and two aromatic rings. The subsequent introduction of substituents at the C1 (Suzuki–Miyaura coupling), C2 (addition to an aldehyde), N3 (alkylation), and C5 positions (Ullman coupling) provided divergent access to dictyodendrins. 相似文献
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Dr. Soumen Dutta Dr. Nitee Kumari Dr. Sateesh Dubbu Sun Woo Jang Dr. Amit Kumar Dr. Hiroyoshi Ohtsu Junghoon Kim Prof. Seung Hwan Cho Prof. Masaki Kawano Prof. In Su Lee 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(9):3444-3450
Rational engineering and assimilation of diverse chemo- and biocatalytic functionalities in a single nanostructure is highly desired for efficient multistep chemical reactions but has so far remained elusive. Here, we design and synthesize multimodal catalytic nanoreactors (MCNRs) based on a mesoporous metal-organic framework (MOF). The MCNRs consist of customizable metal nanocrystals and stably anchored enzymes in the mesopores, as well as coordinatively unsaturated cationic metal MOF nodes, all within a single nanoreactor space. The highly intimate and diverse catalytic mesoporous microenvironments and facile accessibility to the active site in the MCNR enables the cooperative and synergistic participation from different chemo- and biocatalytic components. This was shown by one-pot multistep cascade reactions involving a heterogeneous catalytic nitroaldol reaction followed by a [Pd/lipase]-catalyzed chemoenzymatic dynamic kinetic resolution to yield optically pure (>99 % ee) nitroalcohol derivatives in quantitative yields. 相似文献