N-烟酰基壳寡糖的合成及其诱导烟草抗病毒作用

壳寡糖(chitooligosaccharides,COS)是聚合度为2-20的低聚β-(1,4)-2-脱氧-2-氨基葡萄糖,具有抑菌[1][2]、植物诱抗[3]、提高免疫力[4]、抑制肿瘤[5]、抑制血管紧张素转化酶[6]和降血脂[7][8]等多种生物功能。壳寡糖可生物降解、无毒,其诱导抗病活性已成功应用于多种植物病害的     

Experimental study on scale inhibition performance of a green scale inhibitor polyaspartic acid

Static and dynamic experiments were carried out to validate scale inhibition performance of a green scale inhibitor-polyaspartic acid (PASP). From the static experiment, it was shown that below 60℃, polyaspartic acid is very effective in scale inhibition, with the scale inhibition ratio exceeding 90% with only 3 mg/L PASP for the 600 mg/L hardness solution. For a higher hardness solution of 800 mg/L, the scale inhibition ratio can also reach 90% with 6 and 12 mg/L PASP at 30 and 60℃respectively. The SEM photographs of CaCO3 crystals indicate that the crystal structure transforms from a compact stick-shape to a loose shape so that the scale can be washed away easily instead of being deposited on the heat transfer surface. The dynamic experimental results show that almost no scales formed on the heat trans- fer surface and the fouling thermal resistance decreases extraordinarily if PASP is added in the solution.     

全钒液流单电池充放电行为及特性研究

建立具有外置双饱和甘汞参比电极及双液流电池的实验装置系统.使用该装置可在同一时刻同时测定小型液流单电池充放电时的电池电压、电池正负极电位及正负极开路电位,进而计算充放电过程电池的欧姆内阻降(iR)及其正负极过电位.以石墨毡为电极、Nafion 117作隔膜的全钒液流单电池,在60 mA.cm-2电流密度下,每一充放电循环的平均iR降约占总电压损耗的74%,表明该电池的电压效率受制于电池的欧姆内阻.充放电曲线显示,电池放电终点之所以出现主要是由于电池负极电位在放电末期的快速上升而引起的.本文设计的全钒单电池于60 mA.cm-2下工作时,其电压及能量效率分别达89%和85%,表明该电池结构合理,且石墨毡是钒电池合适的电极材料.     

聚(对亚苯基-1,3,4-噁二唑)纤维表面氟化处理研究

采用氟气(F2)对聚(对亚苯基-1,3,4-噁二唑)(p-POD)纤维表面进行直接氟化处理.衰减全反射红外光谱(ATR-FTIR)和表面电子能谱(XPS)的结果显示,通过直接氟化处理,p-POD纤维较易与F2发生反应,表面大分子链上引入了大量C—F键,表面氟元素含量高达28.2%,且F原子以—CF/C O、—CFH及—CF2形式存在,表明在表面氟化过程中,既有取代反应,也有加成反应.热失重(TGA)结果表明氟化前后p-POD纤维的耐高温性能没有受到影响,X射线衍射图谱(XRD)表明氟化后纤维的聚集态有序性略微增加.氟化前后纤维的断裂强度基本无变化,在体积分数为20%的硫酸溶液中的人工加速酸老化条件下,氟化后纤维在老化120 h后的断裂强力保留率在80%以上,相比氟化前的纤维提高了约90%,即耐酸性得到明显改善.推测表面氟化处理改善p-POD纤维耐酸性的机理是氟化后p-POD纤维表面N元素含量降低,抑制了溶剂化过程;纤维表面致密程度得到提高以及F原子与酸液形成氢键,从而阻止噁二唑环的质子化,延缓了老化进程.     

基于目标物诱导置换及纳米金催化的新型荧光技术检测腺苷

在一定条件下, 磁性纳米颗粒上修饰的腺苷核酸适体与纳米金标记的核酸探针杂交; 再加入目标物腺苷诱导适体构象变换, 并置换出金标探针; 经磁场分离后, 游离的金标探针进一步用于催化抗坏血酸还原铜离子, 使铜离子对钙黄绿素的荧光猝灭得到抑制. 由于极少量的纳米金能够催化大量铜离子还原并沉积在其表面, 铜离子浓度急剧降低, 从而改变钙黄绿素的荧光信号. 实验结果表明, 腺苷的动力学响应浓度范围为100 pmol/L~10 nmol/L, 检出限低至80 pmol/L. 核酸适体的高度特异识别性能保证了该方法具有良好的选择性.     

CoOx-CeOx/ZrO2催化氧化NO性能及抗SO2毒化研究

采用浸渍法制备了一系列CoO_x-CeO_x/ZrO₂催化剂,探讨了催化剂载体、Co含量、Co/Ce配比等对Co基催化剂催化氧化NO活性的影响及其机理。ZrO₂负载的Co氧化物具有优良的低温NO催化氧化活性,铈的添加进一步提高了催化剂的低温活性。其促进机制主要是提高了催化剂吸附氧的能力及改善了Co在催化剂表面的分散。同时,掺杂铈使得催化剂抗SO₂能力有一定增强,呈现出选择性毒化机制。     

过渡金属基MOF材料在选择性催化还原氮氧化物中的应用

选择性催化还原(SCR)技术是目前应用最广泛的工业脱硝技术,研发具有优良活性和抗毒化性能的催化剂体系是研究学者关注的重点。过渡金属氧化物和金属有机骨架(MOF)材料因其优良的氧化还原性能在脱硝领域受到了广泛关注和研究,且研究学者发现将过渡金属氧化物与MOF材料结合能够进一步提高催化剂的脱硝活性。本文综述了近年来主要应用于NH₃-SCR反应的系列单过渡金属基MOF脱硝催化剂和复合过渡金属基MOF脱硝催化剂的研究进展,阐述了过渡金属基MOF脱硝催化剂抗水抗硫中毒性能和热稳定性的强化方法,并展望了未来过渡金属基MOF脱硝催化剂的主要研究方向：综合利用不同过渡金属氧化物的特点并结合金属氧化物间的强相互作用,制备得到具有优良脱硝活性、抗水抗硫性能和热稳定性的新型过渡金属基MOF脱硝催化剂,进一步通过实验和仿真模拟相结合制备高效过渡金属基MOF脱硝催化剂以满足工业化需求。     

超声参数联合血清OPN、IL-1β对乳腺癌的临床诊断价值研究

选取我院收治的乳腺癌(BC)患者82例设为研究组,同期乳腺良性肿瘤患者82例设为对照组,探讨了超声参数联合血清骨桥蛋白(OPN)、白细胞介素-1β(IL-1β)对BC的诊断价值.结果显示,研究组患者病灶处的RI值、PI值和血清OPN、IL-1β水平均高于对照组(P＜0.05);PI值、RI值、血清OPN、IL-1β水平...     

Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents

Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy, radiotherapy and surgery in some cases, cancer cells appear to outsmart and evade almost any method of treatment by developing drug resistance. Quinazolines are the most versatile, ubiquitous and privileged nitrogen bearing heterocyclic compounds with a wide array of biological and pharmacological applications. Most of the anti-cancer agents featuring quinazoline pharmacophore have shown promising therapeutic activity. Therefore, extensive research is underway to explore the potential of these privileged scaffolds. In this context, a molecular hybridization approach to develop hybrid drugs has become a popular tool in the field of drug discovery, especially after witnessing the successful results during the past decade. Histone deacetylases (HDACs) have emerged as an important anti-cancer target in the recent years given its role in cellular growth, gene regulation, and metabolism. Dual inhibitors, especially based on HDAC in particular, have become the center stage of current cancer drug development. Given the growing significance of dual HDAC inhibitors, in this review, we intend to compile the development of quinazoline based HDAC dual inhibitors as anti-cancer agents.