Design and synthesis of fused cyclic sulfamides-oxazolidinones

An efficient protocol for the synthesis of a new series of oxazolidin-2-ones containing sulfamide moieties is described. The synthesis was achieved in two reaction steps. The first was carried out under anhydrous conditions at 0?°C through a selective addition of an alcohol and primary amines to chlorosulfonylisocyanate to produce N-carboxylsulfamides in good yields. Under appropriate conditions of solvent, base and temperature, these intermediates underwent subsequent intramolecular cyclizations, giving exclusively the corresponding sulfamoyloxazolidinones.     

HFO-1234yf as a CF3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl-ynones

Trifluoromethyl ynones derived from the refrigerant gas HFO-1234yf (2,3,3,3-tetrafluoropropene) react with nucleophiles via a Michael-type addition process and the allenolate intermediate formed reacts intramolecularly with a carbonyl group to form heterocyclic derivatives. Thus, reaction of 2-amino and 2-hydroxyl benzaldehyde or ketone substrates with trifluoromethyl ynone derivatives gives trifluoromethyl quinoline and chromene products by a one-pot tandem ring closing sequence, forming pharmaceutically relevant structures from an inexpensive starting material without the need for transition metals or column chromatography. The 2-trifluoromethylquinoline products also show unusual fluxional behaviour, which was explored through 2-D NMR and X-ray crystallographic studies.     

高校无机化学实验室资源合理配置的探索与实践

高校实验室是“立德树人”的重要阵地,实验技术队伍是实现“三全育人”的重要保障。高校快速发展过程中,对实验技术队伍赋予了建设和管理的多重任务,而自身缺乏明确的发展方向和目标,实验技术队伍职业化研究成为高校发展的现实需求。构建适应高等学校发展的实验技术队伍专业化管理体系,明确实验队伍职业化发展路径选择的具体措施,促进实验技术队伍稳定性,强化实验技术队伍在高等学校治理结构和提升内涵建设的有效作用,为提升高校实验室育人功能奠定基础,为高等学校快速发展提供有力支撑。     

基于"微信+问卷星"闯关式化学实验预习模式的创新与实践——以"大学化学实验"为例

实验教学在培养工科学生的动手能力和科学素养等方面起着不可替代的作用。实验预习对于学生形成良好的实验习惯和安全意识攸关重要。本文基于"微信+问卷星"平台对大学化学实验预习模式进行了改革,引入游戏闯关理念,开发出闯关式大学化学实验预习在线考试小程序,以替代传统的纸质预习思考题,引导学生主动接受闯关式挑战,并取得了较好的教学效果。     

吉林大学高分子学科:惟实励新 笃行致远

吉林大学高分子学科创建于1958年,是吉林大学化学学科的重要分支。在64年的学科发展中,一代代吉大高分子人惟实励新、砥砺奋进,建设了具有理工融合特色的高分子专业,培养了大批高分子科学领域的优秀人才。回顾了吉大高分子学科的发展历程,重点介绍了吉大高分子学科在课程建设、人才培养、科学研究等方面的成就进展。在吉大化学70周年华诞之际,谨以此文致敬那些为吉大高分子学科发展做出贡献的校友、同仁和朋友们。     

Copper(II)-cetyltrimethylammonium chloride-chromal blue G ternary complex and its application to the spectrophotometric determination of copper(II)

A sensitive spectrophotometric method for the determination of copper(II) based on a ternary complex with chromal blue G, a triphenylmethane reagent in the presence of cetyltrimethylammonium chloride, is described. The sensitivity of color reaction between copper and chromal blue G has been greatly increased by the sensitizing action of cetyltrimethylammonium chloride, a cationic surfactant. The color development of the ternary complex can be utilized in the highly sensitive spectrophotometric determination of copper. The molar absorptivity of the binary complex between copper and chromal blue G ε_630nm = 9.56 × 10³liters · mol⁻¹ · cm⁻¹ is enchanced on ternary complex formation to ε_{542 nm} = 4.78 × 10⁴liters · mol⁻¹ · cm⁻¹. The ternary complex gave a maximal absorbance at 542 nm in the pH range 9.8–11. Beer's law is obeyed up to at least 1.2 ppm of copper. The maximal absorbance of the ternary complex was found to develop within 5 min and then it remains constant for several hours. The formation constant of the ternary complex is calculated to be 8.6 × 10¹⁰ under these conditions.     

Palladium-catalyzed annulation of 2-(aryldiazenyl) aniline with dimethyl sulfoxide to access N-aryl-1H-benzo[d]imidazol-1-amine

A palladium-catalyzed annulation of 2-(aryldiazenyl) aniline and dimethyl sulfoxide was developed to access N-aryl-1H-benzo[d]imidazol-1-amine in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a “CH” fragment during this procedure. It represents a facile pathway leading to benzimidazoles.     

Two new dimmeric xanthanolides isolated from Xanthium mogolium Kitag plant

Two xanthanolide-type dimmers, namely Mogolide D (4) and Mogolide E (5) are isolated from the aerial parts of Xanthium mogolium Kitag plant collected from Heilongjiang province, China. The dimmers’ relative structures are elucidated on the basis of HRESIMS, IR spectrum and NMR spectroscopy. The absolute configurations of them are assigned with ECD spectra. The biosynthetic pathway of the two dimmers is also proposed. Besides, Mogolide D (4) and Mogolide E (5) are tested against MDA-MB-231 breast cancer cell line with IC₅₀ 8.46 μM and 19.20 μM, respectively.     

Two novel C18-diterpenoid alkaloids,sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum

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吉尔伯特·牛顿·路易斯——加州大学伯克利分校化学系的缔造者*

吉尔伯特·牛顿·路易斯是20世纪最伟大的化学家之一。在加州大学伯克利分校,路易斯通过大力引进人才、提倡学术民主和学术合作、改革人才培养模式,逐步建立起了世界上最强大、最具创造力的化学系之一,培养了一批日后在化学领域做出了重大贡献的博士研究生。介绍了路易斯担任加州大学伯克利分校化学学院院长兼化学系主任期间的教育改革措施。