Stripping extraction calculation and simulation for CYCIAE-100

A 100 MeV H- compact cyclotron is under construction at China Institute of Atomic Energy (CYCIAE-100). The proton beams of 75 MeV-100 MeV at an intensity of 200 μA will be extracted in dual opposite directions by charge exchange stripping devices. The crossing point at the switching magnet center is fixed inside the magnet yoke and the stripping points for various extraction energies are calculated by the code CYCTRS. With the code GOBLIN, we can calculate the transfer matrix including the dispersion effects from the stripping point to the switch magnet. The beam distribution just after stripping foil can be obtained from the multi-particle tracking code COMA and the extracted beam parameters after the switch magnet such as emittance, envelope, dispersion, energy spread, bunch length, etc. are given by the extraction orbit simulations.     

Synthesis and Crystal Structure of 7-Ethoxycarbonyl-2-methyl-6-methylthio-1H-imidazo[1,2-b]pyrazole

The title compound 7-ethoxycarbonyl-2-methyl-6-methylthio-lH-imidazo[1,2-b]- pyrazole （Mr = 239.29） was synthesized and structurally characterized by IR, ^1H NMR and single-crystal X-ray diffraction. It belongs to the triclinic system, space group P1, with a =8.0461（10）, b = 8.5534（11）, c = 9.5605（12）А,α= 64.804（2）,β= 74.231（2）, γ= 76.885（2）°, V = 568.27（12）А^3, Z = 2,Dc= 1.398 g/cm^3,μ= 0.274 nunl, F（000） - 252, the final R = 0.0454 and wR = 0.1261. A total of 3360 reflections were collected, of which 2466 were independent （R_int = 0.0138） and 2154 were observed with I〉2σ（I）.     

聚集诱导发光天然产物:从发现到其多功能应用

来自于天然产物的聚集诱导发光(AIE)材料具有无需化学合成、生物兼容性好、天然可降解、药理活性等优点,正在逐渐成为环境监测、生物成像和疾病诊断等领域的有力工具.本文综述了目前从天然产物中发现的AIE材料,包括黄连素等生物碱、槲皮素等类黄酮多酚、丹宁酸等非类黄酮多酚以及其他皂苷、维生素等天然化合物.这些材料的发光机制主要有分子运动受限(RIM)、扭转分子内电荷转移(TICT)、激发态分子内质子转移(ESIPT)、J-聚集、簇发光(CTE)等.基于显著的AIE特性,这些天然产物表现出在pH、离子及生物标志物传感、细胞成像和生物诊疗等领域的巨大应用潜力.期望本文能够加深对聚集诱导发光现象的理解,启发对来源于天然产物的AIE分子的探索及新应用的开发.     

新型1,1-二氧代-4H-苯并[1,2,4]-噻二嗪类衍生物的合成及其抗肿瘤活性

以2-硝基苯磺酰氯为起始原料,经多步反应合成了12种新型1,1-二氧代-4H-苯并[1,2,4]-噻二嗪类衍生物,产物收率高,水溶性好,并经¹H NMR、¹³C NMR、MS-ESI和元素分析法确证结构。 用MTT法测试了这类衍生物对肝癌细胞HepG-2生长的抑制作用,结果显示目标化合物能不同程度地抑制肿瘤细胞生长,其中7-氨甲基-3-环丙基-1,1-二氧代-4H-苯并[1,2,4]-噻二嗪 (7c)对肝癌细胞HepG-2的抗性显著,最高抑制率达到79.3%。     

BCH-代数的模糊理想与模糊H-理想

在BCK／BCI／BCC代数中Fuzzy理想被广泛研究，但在BCH-代数中还没有讨论过。在BCH-代数中引人了Fuzzy理想与FuzzyH-理想的概念，并讨论它们的性质。     

铜纳米簇的制备、聚集诱导荧光增强性能及应用研究进展

铜纳米簇不仅具有金属纳米簇的特异性,还有前驱体价格便宜等优点,因此有广泛的应用前景。从配体辅助法、模板法、微波法、电化学法和刻蚀法等综述了铜纳米簇的制备方法。从离子诱导聚集、pH诱导聚集、组装诱导聚集和溶剂诱导聚集增强发射等方面综述了铜纳米簇聚集诱导荧光发射增强性能。从离子检测、小分子检测、酶活性检测、生物大分子检测和生物成像等方面综述了铜纳米簇的应用,并对铜纳米簇的制备、性能优化和应用等方面作了展望。