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Dasireddi Chandra Rao Vanam Shekhar Dorigondla Kumar Reddy Baggu Chinnababu Yenamandra Venkateswarlu 《Helvetica chimica acta》2013,96(12):2179-2184
A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO4‐catalyzed cis‐hydroxylation and selective reduction with K‐Selectride as key steps. 相似文献
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Quy Hung Trieu Marc Litaudon Dao Phi Thi Tuan Anh Tran Van Hung Nguyen 《Natural product research》2018,32(3):287-293
Two new linear acetogenins, gracilipin A (1) and methylsaccopetrin A (2) along with seven known compounds, saccopetrin A (3), 7,3′,4′-trimethylquercetin (4), rhamnazin (5), casticin (6), isokanugin (7), melisimplexin (8) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (9) were isolated from the fruits of Goniothalamus gracilipes Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds 1 and 3 showed cytotoxic activity against KB cell line with IC50 values of 14.6 and 15.3 μM, respectively. 相似文献
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Pongpol Thanuphol Yukihiro Asami Kazuro Shiomi Ariyaphong Wongnoppavich Patoomratana Tuchinda 《Natural product research》2018,32(14):1682-1689
The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC50 values of 14.87 and 15.18 μM against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC50 values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively. 相似文献
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Qing MU * Rong Wei TENG Chao Ming LI De Zu WANG Yu WU Han Dong SUN Chang Qi HU Phytochemistry Laboratory Kunming Institute of Botany Chinese Acadmy of Sciences Kunming School of Pharmacy Fudan University Shanghai 《中国化学快报》2001,(7)
Ongoing phytochemical studies on Goniothalamus species have led to the isolation of a number of annonaceous acetogenins and unusual new styryllactones which were found to possess significant cytotoxic activities against several hunan tumour cell lines1,2. Firstly, cyclopeptides were reported to be isolated from genus Goniothalamus in this paper.Goniothalamus leiocarpus is an evergreen tree which grows in the south of Yunnan, China. Four new anticancer styryllactones3,4 from the stem bark and… 相似文献
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SiWANG ShengJunDAI RuoYunCHEN ShiShanYU DeQuanYU 《中国化学快报》2003,14(5):487-488
Two new styryllactones,iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone,were isolated from the roots of Goniothalamus cheliensis.Their structure were elucidated on the basis of spectroscopic and chemical evidences. 相似文献