Friction factors of finite and infinite square arrays of roughened pins

Friction factors of square arrays of roughened pins in smooth channels have been measured for a range of pin pitch to diameter ratios and roughness heights and for different sizes of array. The influence of the smooth channel has been removed in two ways; by extrapolating the results for a fixed pitch-to-diameter ratio to an infinite number of pins and by calculation from the finite array results. The resultant friction factors are compared with each other and with data obtained by testing single pins in smooth circular channels and transforming by various methods to the fully rough situation.     

Stress concentration around a spheroidal crack caused by a harmonic wave incident at an arbitrary angle

A method is proposed to study the stress concentration around a shallow spheroidal crack in an infinite elastic body. The stress concentration is due to the diffraction of a low-frequency plane longitudinal wave by the crack. The direction of wave propagation is established in which the combined concentration of mode I and mode II stresses is maximum __________ Translated from Prikladnaya Mekhanika, Vol. 42, No. 1, pp. 70–77, January 2006.     

平面弹性介质多孔多裂纹问题的一种数值方法

提出了平面弹性介质中多孔洞多裂纹相互作用问题的一种数值计算方 法. 通过把适于单一裂纹的Bueckner原理扩充到含有多孔洞多裂纹的一般体系，将原问题 分解为承受远处载荷不含裂纹不含孔洞的均匀问题，和在远处不承受载荷但在裂纹面上和孔 洞表面上承受面力的多孔洞多裂纹问题. 于是，以应力强度因子作为参量的问题可以通过考 虑后者(多孔洞多裂纹问题)来解决，而利用提出的杂交位移不连续法，这种多孔 洞多裂纹问题是容易数值求解的. 算例说明该数值方法对分析平面弹性介质中多孔洞多裂纹 相互作用的问题既简单又有效.     

Fatigue crack growth behavior of Al7050-T7451 attachment lugs under flight spectrum variation

This paper discusses an analytical and experimental investigations of the fatigue crack growth behavior in attachment lugs subjected to a randomized flight-by-flight spectrum. In the analysis, the stress intensity factors for through-the-thickness cracks initiating from lug holes were compared by weight function method, boundary element method (BEM), the interpolation of Brussat’s solution. The stress intensity factors of a corner crack at a transition region were obtained using two parameter weight function method and correction factors. Fatigue life under a load spectrum was predicted using stress intensity factors and Willenborg retardation model considering the effects of a tensile overload. Experiments were performed under a load spectrum and compared with the fatigue life prediction using the stress intensity factors by different methods. Changes of fatigue life and aspect ratio according to the clipping level of the spectrum were discussed through experiment and prediction. Effect of the spectrum clipping level on the fatigue life was experimentally evaluated by using beach marks of fractured surface.     

On the gamma factor of the triple product L-functions

Let π₁ and π₂ be essentially (limit of) discrete series representations of GL₂(R), and π₃ be a principal series representation of GL₂(R). We calculated the gamma factor of the triple product L-function L(s,π₁×π₂×π₃) by constructing the normalized good sections and Whittaker functions for πi explicitly and showed that they coincide the functions which have been predicted by Langlands philosophy.     

水资源短缺风险因子的筛选模型

水资源短缺评价首先需要确定指标体系,投影寻踪模型与灰色关联度法相结合,可以有效地筛选出水资源短缺风险因子,为进一步进行风险评价奠定了基础,同时也为制定风险的防范措施和对策提供了理论依据.综合应用这两种模型,对北京市2001～2009年的水资源短缺风险进行研究,结果表明:降水量、日照时数、雨日数、单位GDP污水排放量、人均GDP、工业总产值占有率、污水处理率和水循环使用率这8个指标是北京市水资源短缺的主要风险因子.     

One target, different effects: a comparison of distinct therapeutic antibodies against the same targets

To date, more than 30 antibodies have been approved worldwide for therapeutic use. While the monoclonal antibody market is rapidly growing, the clinical use of therapeutic antibodies is mostly limited to treatment of cancers and immunological disorders. Moreover, antibodies against only five targets (TNF-α, HER2, CD20, EGFR, and VEGF) account for more than 80 percent of the worldwide market of therapeutic antibodies. The shortage of novel, clinically proven targets has resulted in the development of many distinct therapeutic antibodies against a small number of proven targets, based on the premise that different antibody molecules against the same target antigen have distinct biological and clinical effects from one another. For example, four antibodies against TNF-α have been approved by the FDA -- infliximab, adalimumab, golimumab, and certolizumab pegol -- with many more in clinical and preclinical development. The situation is similar for HER2, CD20, EGFR, and VEGF, each having one or more approved antibodies and many more under development. This review discusses the different binding characteristics, mechanisms of action, and biological and clinical activities of multiple monoclonal antibodies against TNF-α, HER-2, CD20, and EGFR and provides insights into the development of therapeutic antibodies.     

Mode III fracture of an arbitrary oriented crack in two dimensional functionally graded material

In this paper, a two dimensional functionally graded material (2D-FGM) under an anti-plane load with an internal crack is considered. The crack is oriented in an arbitrary direction. The material properties are assumed to vary exponentially in two planar directions. The problem is analyzed and solved by two different methods namely Fourier integral transforms with singular integral equation technique, and then by the finite element method. The effects of crack orientation, material non-homogeneity, and other parameters on the value of stress intensity factor (SIF) are studied. Finally, the obtained results for Mode III stress intensity factor of different methods are compared.     

一种基于数独的新试验设计

通过研究数独方的构成与设计,建立了一种基于数独的新试验设计,给出了这种设计的数学模型与统计分析。该设计能安排单因素的n个水平,并能在行、列、块3个方向控制变异性。