In this paper, we review blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies addressing the neural correlates of touch, thermosensation, pain and the mechanisms of their cognitive modulation in healthy human subjects. There is evidence that fMRI signal changes can be elicited in the parietal cortex by stimulation of single mechanoceptive afferent fibers at suprathreshold intensities for conscious perception. Positive linear relationships between the amplitude or the spatial extents of BOLD fMRI signal changes, stimulus intensity and the perceived touch or pain intensity have been described in different brain areas. Some recent fMRI studies addressed the role of cortical areas in somatosensory perception by comparing the time course of cortical activity evoked by different kinds of stimuli with the temporal features of touch, heat or pain perception. Moreover, parametric single-trial functional MRI designs have been adopted in order to disentangle subprocesses within the nociceptive system.
Available evidence suggest that studies that combine fMRI with psychophysical methods may provide a valuable approach for understanding complex perceptual mechanisms and top-down modulation of the somatosensory system by cognitive factors specifically related to selective attention and to anticipation. The brain networks underlying somatosensory perception are complex and highly distributed. A deeper understanding of perceptual-related brain mechanisms therefore requires new approaches suited to investigate the spatial and temporal dynamics of activation in different brain regions and their functional interaction. 相似文献
The recently introduced Gas in Scattering Media Absorption Spectroscopy (GASMAS) technique provides novel possibilities for analysis in biophotonics. Free gas in pores or cavities is monitored with narrow‐band laser radiation, which can discern the gas absorptive imprints which are typically several orders of magnitude more narrow than the features of the surrounding tissue through which the diffusely scattered light emerges to the detector. Important gases monitored are oxygen and water vapour. Applications include diagnosis of human sinus cavities and surveillance of neonatal children, but also characterization of food‐stuffs, food packages and pharmaceutical preparations. Non‐biological applications include the study of construction materials such as wood, polystyrene foams and ceramics. For nano‐porous materials, information on the pore sizes can be obtained from observed line broadening. Apart from concentration measurements, the GASMAS technique also allows the study of gas transport and diffusion, and pressure and temperature information can also be obtained. 相似文献
A general approach to transference principles for discrete and continuous operator (semi)groups is described. This allows one to recover the classical transference results of Calderón, Coifman and Weiss and of Berkson, Gillespie and Muhly and the more recent one of the author. The method is applied to derive a new transference principle for (discrete and continuous) operator semigroups that need not be groups. As an application, functional calculus estimates for bounded operators with at most polynomially growing powers are derived, leading to a new proof of classical results by Peller from 1982. The method allows for a generalization of his results away from Hilbert spaces to Lp-spaces and—involving the concept of γ-boundedness—to general Banach spaces. Analogous results for strongly-continuous one-parameter (semi)groups are presented as well. Finally, an application is given to singular integrals for one-parameter semigroups. 相似文献
Shape memory alloys (SMA) exhibit a number of features which are not easily explained by equilibrium thermodynamics, including hysteresis in the phase transformation and “reverse” shape memory in the high symmetry phase. Processing can change these features: repeated cycling can “train” the reverse shape memory effect, while changing the amount of hysteresis and other functional properties. These effects are likely to be due to formations of localised defects and these can be studied by atomistic methods. Here we present a molecular dynamics simulation study of such behaviour employing a two-dimensional, binary Lennard-Jones model. Our atomistic model exhibits a symmetry breaking, displacive phase transition from a high temperature, entropically stabilised, austenite-like phase to a low temperature martensite-like phase. The simulations show transformations in this model material proceed by non-diffusive nucleation and growth processes and produce distinct microstructures. We observe the generation of persistent lattice defects during forward-and-reverse transformations which serve as nucleation centres in subsequent transformation processes. These defects interfere the temporal and spatial progression of transformations and thereby affect subsequent product morphologies. During cyclic transformations we observe accumulations of lattice defects so as to establish new microstructural elements which represent a memory of the previous morphologies. These new elements are self-organised and they provide a basis of the reversible shape memory effect in the model material. 相似文献
This paper deals with a nonparametric estimation of conditional quantile regression when the explanatory variable X takes its values in a bounded subspace of a functional space X and the response Y takes its values in a compact of the space Y?R. The functional observations, X1,…,Xn, are projected onto a finite dimensional subspace having a suitable orthonormal system. The Xi’s will be characterized by their coordinates in this basis. We perform the Support Vector Machine Quantile Regression approach in finite dimension with the selected coefficients. Then we establish weak consistency of this estimator. The various parameters needed for the construction of this estimator are automatically selected by data-splitting and by penalized empirical risk minimization. 相似文献
In the present article, we apply the variational iteration method to obtain the numerical solution of the functional integral equations. This method does not need to be dependent on linearization, weak nonlinearity assumptions or perturbation theory. Application of this method in finding the approximate solution of some examples confirms its validity. The results seem to show that the method is very effective and convenient for solving such equations. 相似文献