靶向分子羧甲基多糖与DNA作用机理研究

以溴化乙锭(EB)为荧光探针,结合紫外光谱法研究了壳聚糖、羧甲基壳聚糖、羧甲基纤维素与DNA的相互作用,药物分子与DNA作用程度可用作用常数D来表示,实验表明: 几种生物多糖与DNA分子的作用强弱顺序为: 壳聚糖＞羧甲基壳聚糖＞羧甲基纤维素;多糖主要以嵌插方式与DNA作用, 使EB-DNA荧光猝灭。     

配合物1,3-二甲基-2-二茂铁基甲基苯并咪唑的量子化学DFT研究

苯并咪唑及其衍生物具有良好的生物活性和荧光性质[1,2],在DNA拓扑酶抑制剂、HIV逆转录酶的抑制剂、分子探针等领域已有广泛应用,一直以来都是广大学者研究的热点[3]。苯并咪唑类化合物是一类活性很强的内吸型杀菌剂,它的主要作用方式是植物病原的R-微管蛋白结合,破坏R-微管蛋白的功能,抑制真菌的有丝分裂和形态建构。然而,随着使用时间的增加,病菌的抗生越来越强,导致在部分地区失效,给农业生产带来巨大损失。所以迫切需要寻找高效、新型的杀菌剂。近些年来,二茂铁衍生物因其广泛的生物活性,如抗癌、杀菌、杀虫、抗炎及调节植物生长等…     

嵌入Y型分子筛中钯簇合成与结构的研究

Pd clusters encaged in Y-zeolite (Pd0Y) have been prepared by means of exchanging zeolite HY with [Pd(NH3)4]2+ under microwave radiation. The product formed was deaminized by heating, washed sufficiently with de-ionized water and reduced with hydrogen. The crystal phase diffraction of Pd was not found in the XRD spectrogram of Pd0y. According to polycrystal X-ray diffraction data. Radial Electron Distribution Function (REDF) of Pd0Y was calculated to elucidate the structure of Pd cluster. The results show that the Pd clusters are of the Al type closely packed arrangement. The dimension of them is about 12 Å. They are encaged in the supercage of zeolite Y. Their occupancy on the supercage is as small as 0.06 so that the framework structure of zeolite Y is unchanged. Therefore, the high dispersing Pd cluster aggregating in supercage exhibit strong catalytic effect. The CO-conversion of Pd0Y with Pd 0.72% and 6.13% (in mass fraction) is 67 % and 100 % (in volume fraction) respectively. Evaluation conditions:
mixed gas containing 0.02% CO and air,
space velocity 3000 h-1,
reaction temperature 0 ℃.     

Gradient type noises II - Systems of stochastic partial differential equations

The present paper is the second and main part of a study of partial differential equations under the influence of noisy perturbations. Existence and uniqueness of function solutions in the mild sense are obtained for a class of deterministic linear and semilinear parabolic boundary initial value problems. If the noise data are random, the results may be seen as a pathwise approach to SPDE's. For typical examples, such as spatially one-dimensional stochastic heat equations with additive or multiplicative perturbations of fractional Brownian type, we recover and extend known results. In addition, we propose to consider partial noises of low order.     

概率约束下最优解的统计影响函数

本文把稳健统计的影响函数概念引入到了概率约束下的随机规划模型中．在一定条件下,得到了三个模型最优解的影响函数表达式．     

基于离散小波变换的蛋白质结构、功能与进化关系延时交叉相关分析

基于氨基酸的疏水特性, 将离散小波变换与延时交叉相关分析相结合, 提出了一种分析蛋白质结构、功能和进化关系的新方法——序列小波层次相关法. 以丝氨酸蛋白酶超家族中Trypsin种属为研究对象, 描述了该方法在揭示不同物种的Trypsin蛋白质进化关系中的应用; 以蛋白质酪氨酸磷酸酶、血红蛋白和溶菌酶为例, 采用该方法揭示了蛋白质之间功能与序列的内在关系. 该方法为非参数方法, 具有简单、直观、可视和可操作性强等特点, 且不需要事先知道蛋白质的结构, 仅从蛋白质的氨基酸序列出发即可比较和揭示蛋白质之间的关系.     

Two-dimensional function photonic crystals

In this paper, we have studied two-dimensional function photonic crystals, in which the dielectric constants of medium columns are the functions of space coordinates , that can become true easily by electro-optical effect and optical kerr effect. We calculated the band gap structures of TE and TM waves, and found the TE (TM) wave band gaps of function photonic crystals are wider (narrower) than the conventional photonic crystals. For the two-dimensional function photonic crystals, when the dielectric constant functions change, the band gaps numbers, width and position should be changed, and the band gap structures of two-dimensional function photonic crystals can be adjusted flexibly, the needed band gap structures can be designed by the two-dimensional function photonic crystals, and it can be of help to design optical devices.     

基于公式真度的公式集约简

基于经典命题逻辑的真度理论,讨论了经典命题逻辑系统当中公式集的约简问题。提出了真度约简及α-真度约简的概念,为公式集的约简提供了一种可行的操作方法。     

A characterization of

This work is devoted to the relationship between topological properties of a space and those of (= the space of continuous real-valued functions on , with the topology of pointwise convergence). The emphasis is on -compactness of and on location of in . In particular, -compact cosmic spaces are characterized in this way.