胃肠道正常组织与相应肿瘤组织结构的FTIR光谱研究

本文用傅里叶变换红外显微光谱对一系列胃肠道（食道、胃、结肠）肿瘤组织和相应正常组织的冰冻切片进行了研究。结果显示，所有肿瘤组织的光谱基本一致。而正常组织的光谱按１４００－９５０ｃｍ＾－１区域的特点可分为三类。对光谱中蛋白质酰胺Ｉ带曲线拟合的结果表明，正常组织和肿瘤组织中蛋白质的二级结构有着很大的差别。     

A combined temperature-dependent electron and single-crystal X-ray diffraction study of the fresnoite compound Rb2VV2O8

High-purity Rb₂V₃O₈ has been grown and temperature-dependent electron and single-crystal X-ray diffraction used to carefully investigate its fresnoite-type reciprocal lattice. In contrast to other recently investigated representatives of the fresnoite family of compounds, Rb₂V₃O₈ is not incommensurately modulated with an incommensurate basal plane primary modulation wave vector given by q∼0.3 〈110〉^*. A careful low-temperature electron diffraction study has, however, revealed the existence of weak incommensurate satellite reflections characterized by the primitive primary modulation wave vector q₁∼0.16c^*. The reciprocal space positioning of these incommensurate satellite reflections, the overall (3+1)-d superspace group symmetry, as well as the shapes of the refined displacement ellipsoids determined from single-crystal XRD refinement, are all consistent with their arising from a distinct type of condensed rigid unit modes (RUMs) of distortion of the Rb₂V₃O₈ parent structure.     

Producing acoustic ‘Frozen Waves’: Simulated experiments with diffraction/attenuation resistant beams in lossy media

The so-called Localized Waves (LW), and the “Frozen Waves” (FW), have raised significant attention in the areas of Optics and Ultrasound, because of their surprising energy localization properties. The LWs resist the effects of diffraction for large distances, and possess an interesting self-reconstruction —self-healing— property (after obstacles with size smaller than the antenna’s  ); while the FWs, a sub-class of LWs, offer the possibility of arbitrarily modeling the longitudinal field intensity pattern inside a prefixed interval, for instance 0?z?L$0?z?L$, of the wave propagation axis. More specifically, the FWs are localized fields “at rest”, that is, with a static envelope (within which only the carrier wave propagates), and can be endowed moreover with a high transverse localization.     

高效液相色谱法检测冷冻烤鳗中恩诺沙星等药物残留

论述了高效液相色谱法检测冷冻烤鳗中恩诺沙星、环丙沙星、诺氟沙星等合成抗菌剂残留的方法。样品以乙腈为提取剂,经脱脂、浓缩、净化,用流动相溶解。高效液相色谱荧光检测器测定。各标准曲线线性范围为0.005～1.000mg·kg-1,回收率为86.2%～92.3%,检出限分别为1,2,2μg·kg-1。     

Strength criterion and elastoplastic constitutive model of frozen silt in generalized plastic mechanics

Triaxial compressive tests of frozen silt were carried out under confining pressures from 0.0 to 14.0 MPa at the temperatures of −2, −4 and −6 °C. A strength criterion based upon experimental results is presented by the combination of extended Lade–Duncan strength function f_π(θ) in π-plane and f_p–q(p) in p–q-plane. In order to describe the deformation characteristic of frozen silt, an elastoplastic constitutive model in generalized plastic mechanics has been proposed for the nonlinear behavior of frozen silt, such as the pressure melting and crushing phenomena, strain softening/hardening characteristics and dilatation, etc., by employing an elliptical yield surface, together with a non-associated flow rule for the compressive mechanism, and two parabolic yield surfaces, together with non-associated flow rules for the shear mechanism. The validity of the model is verified by comparing its modeling results with the results of triaxial compressive tests. It is found that the stress–strain curves predicted by this model agree well with the corresponding experimental results both under low and high confining pressures.     

Stability Analysis of a Porous Layer Heated from Below and Subjected to Low Frequency Vibration: Frozen Time Analysis

We investigate the convection amplitude in an infinite porous layer subjected to a vibration body force that is collinear with the gravitational acceleration and heated from below. The analysis focuses on the specific case of low frequency vibration where the frozen time approximation is used. The results reveal that for moderate Vadasz numbers, increasing the magnitude of the acceleration stabilizes the convection. The results of the large Vadasz number analysis reveals that the acceleration plays a passive role in the stability of convection and the classical stability criteria for Rayleigh–Benard convection applies.     

A general theory for the Frozen Waves and their realization through finite apertures

In this paper, we present a generalization of the so-called Frozen Waves, which are new solutions to Maxwell’s equations having the important characteristic of remaining static in space and keeping any previously chosen arbitrary longitudinal field pattern. In the pioneering work, these waves were introduced as a discrete superposition of zero-order Bessel beams. As a fact, here we will represent these waves as a continuous superposition of Bessel beams leading to a simpler and more compact mathematical formalism, which allows us to derive certain inequalities that restrict the physical properties of the Frozen Waves, such as their attainable longitudinal resolution. Besides this, we will discuss losses compensation in a lossy medium and, finally, their practical realization through finite apertures.     

Frozen water phase method for logD measurement using a 96-well plate

In this study, a frozen water phase method for log D measurement using a 96-well plate was developed. In the case of log D measurement of compounds, the problem of octanol contamination often occurs; in lipophilic compounds, the concentration of the octanol phase is much higher than that of the water phase. When the water phase is separated from the octanol phase, a small amount of octanol phase contamination could strongly influence the concentration of the water phase. To avoid this problem, the frozen water phase method was developed. The water phase was frozen in liquid nitrogen and then the unfrozen octanol phase was removed. To remove the portion of the octanol remaining on the frozen water phase, the surface of the frozen water phase was washed with octanol and water/ethanol (50/50, v/v). The validity of the method was confirmed by results of commercially available drugs at the log D range from 0 to 4. Further, it was found that this method had the ability to evaluate the pH-log D profile of compounds in the range from pH 2 to pH 12. As a result, we developed the convenient and accurate method that is effective in preventing contamination with a wide dynamic range.