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41.
ISO radiation sterilization standards 总被引:2,自引:0,他引:2
This presentation provides an overview of the current status of the ISO radiation sterilization standards. The ISO standards are voluntary standards which detail both the validation and routine control of the sterilization process. ISO 11137 was approved in 1994 and published in 1995. When reviewing the standard you will note that less than 20% of the standard is devoted to requirements and the remainder is guidance on how to comply with the requirements.
Future standards developments in radiation sterilization are being focused on providing additional guidance. The guidance that is currently provided in informative annexes of ISO 11137 includes: device/packaging materials, dose setting methods, and dosimeters and dose measurement, currently, there are four Technical Reports being developed to provide additional guidance:
- 1. 1. AAMI Draft TIR, “Radiation Sterilization Material Qualification”
- 2. 2. ISO TR 13409-1996, “Sterilization of health care products — Radiation sterilization — Substantiation of 25 kGy as a sterilization dose for small or infrequent production batches”
- 3. 3. ISO Draft TR, “Sterilization of health care products — Radiation sterilization Selection of a sterilization dose for a single production batch” li]4. ISO Draft TR, “Sterilization of health care products — Radiation sterilization-Product Families, Plans for Sampling and Frequency of Dose Audits.”
42.
Constraint qualifications in quasidifferentiable optimization 总被引:1,自引:0,他引:1
The classical linearization procedure for differentiable nonlinear programming problems can be naturally generalized to the quasidifferentiable case. As in the classical case one has to impose so-called constraint qualifications on the constraint functions in order to ensure that optimality of a feasible point implies optimality of the nullvector for the corresponding quasilinearized problem. We present various constraint qualifications in a unified setting, propose a new one, and investigate the relations between these conditions.Supported by DFG Grant Pa 219/5-1. 相似文献
43.
44.
We consider optimization problems with a disjunctive structure of the feasible set. Using Guignard-type constraint qualifications
for these optimization problems and exploiting some results for the limiting normal cone by Mordukhovich, we derive different
optimality conditions. Furthermore, we specialize these results to mathematical programs with equilibrium constraints. In
particular, we show that a new constraint qualification, weaker than any other constraint qualification used in the literature,
is enough in order to show that a local minimum results in a so-called M-stationary point. Additional assumptions are also
discussed which guarantee that such an M-stationary point is in fact a strongly stationary point.
相似文献
45.
46.
Oliver Stein 《计算数学(英文版)》2006,24(6):719-732
We study the smoothing method for the solution of generalized semi-infinite optimiza-tion problems from(O.Stein,G.Still:Solving semi-infinite optimization problems withinterior point techniques,SIAM J.Control Optim.,42(2003),pp.769-788).It is shownthat Karush-Kuhn-Tucker points of the smoothed problems do not necessarily converge toa Karush-Kuhn-Tucker point of the original problem,as could be expected from resultsin(F.Facchinei,H.Jiang,L.Qi:A smoothing method for mathematical programs withequilibrium constraints,Math.Program.,85(1999),pp.107-134).Instead, they mightmerely converge to a Fritz John point.We give,however,different additional assumptionswhich guarantee convergence to Karush-Kuhn-Tucker points. 相似文献
47.
48.
Michael L. Flegel 《Journal of Mathematical Analysis and Applications》2005,310(1):286-302
Mathematical programs with equilibrium constraints are optimization problems which violate most of the standard constraint qualifications. Hence the usual Karush-Kuhn-Tucker conditions cannot be viewed as first order optimality conditions unless relatively strong assumptions are satisfied. This observation has lead to a number of weaker first order conditions, with M-stationarity being the strongest among these weaker conditions. Here we show that M-stationarity is a first order optimality condition under a very weak Abadie-type constraint qualification. Our approach is inspired by the methodology employed by Jane Ye, who proved the same result using results from optimization problems with variational inequality constraints. In the course of our investigation, several concepts are translated to an MPEC setting, yielding in particular a very strong exact penalization result. 相似文献
49.
F. Giannessi 《Journal of Optimization Theory and Applications》1984,42(3):331-365
A theorem of the alternative is stated for generalized systems. It is shown how to deduce, from such a theorem, known optimality conditions like saddle-point conditions, regularity conditions, known theorems of the alternative, and new ones. Exterior and interior penalty approaches, weak and strong duality are viewed as weak and strong alternative, respectively. 相似文献
50.
The constructed hierarchical optimization model of vintage capital replacement takes into account network effects and the
age-dependent technological structure of capital equipment. It involves the control of a network coalition choice, endogenous
investments, capital structure, and capital lifetime. The qualitative analysis of the model shows how the lifetime and financial
structure of the IT capital depends on technological change. These results are relevant for strategic management on a firm
level. Provided numeric examples simulate the optimal lifetime of personal computers.
This research is partially supported by the NATO grant CLG 982209. 相似文献