Analysis of Thermal Decomposition Patterns of Aromatic and Heteroaromatic Amino Acids

Abstract

Differential enthalpic analysis of the thermal degradation of aromatic and heteroaromatic amino acids provides thermograms which are characteristic of specific amino acids (e.g. phenylalanine, tyrosine, tryptophan or histidine). Curve resolution of the resulting thermograms suggests that a minimum of three reactions are involved in the degradation (within the temperature limits of 500–620 [ddot]K) and provides T_M values for each of these concurrent reactions.     

有序处理连续比较的置信区间

为有序均值的连续比较提出了一个新的检验过程.他们的过程对满足简单序的均值有重要的应用价值,例如在研究增长剂量对药物效用的影响. 与其它检验过程相比(例:Hayter\ucite{4}中的检验), 其优点在于产生了更短的连续比较的置信限,从而能够提供更多机会发现在何药剂量处有不同的效用.但作为有序均值的齐性检验, 它的势表现远劣于其它检验.本文的目的是提出一检验过程在尽量保持Lee andSpurrier\ucite{8}检验的优点的同时大大地提高其势表现.     

包含双边投资规范的自由贸易协定网络

当今国际经济趋势表明,包含投资规范的双边自由贸易协定(bilateral FTAs)受到了越来越多国家的欢迎。通过假定双边自由贸易协定包含着无限制对外直接投资规范,基于Goyal和Joshi(2006)^[1],本文构建了相应FTA网络形成博弈模型。本文发现:(1)星状FTA网络是两两稳定的;(2)从空FTA网络到星状FTA网络存在一条个体国家福利和世界福利都严格改善的路径。     

Hydrotrope型两亲化合物的合成和自缔合研究

合成了一种hydrotrope型可聚合两亲化合物4-(2-(丙烯酰氧基)乙氧基)苯甲基三乙基溴化铵(AEBA),应用紫外吸收光谱和荧光探针技术研究了它的溶液性质和自缔合作用,实验结果表明,AEBA在水溶液中具有较高的自缔合能力、表面活性和增溶作用,它对油溶性染料荧光素二乙酸酯(fluorescein diacetate,FDA)的最小助溶浓度(minimum hydrotrope concentration,MHC)约为0.05 mol/L,AEBA分子间缔合形成不同于表面活性剂胶束结构的堆砌状(stack-type)聚集体结构。     

Quintessential PBDs and PBDs with prime power block sizes ≥ 8

In this paper, we look at the existence of (v K) pairwise balanced designs (PBDs) for a few sets K of prime powers ≥ 8 and also for a number of subsets K of {5, 6, 7, 8, 9}, which contain {5}. For K = {5, 7}, {5, 8}, {5, 7, 9}, we reduce the largest v for which a (v, K)‐PBD is unknown to 639, 812, and 179, respectively. When K is Q_≥8, the set of all prime powers ≥ 8, we find several new designs for 1,180 ≤ v ≤ 1,270, and reduce the largest unsolved case to 1,802. For K =Q_0,1,5(8), the set of prime powers ≥ 8 and ≡ 0, 1, or 5 (mod 8) we reduce the largest unknown case from 8,108 to 2,612. We also obtain slight improvements when K is one of {8, 9} or Q_0,1(8), the set of prime powers ≡ 0 or 1 (mod 8). © 2004 Wiley Periodicals, Inc.     

Molecular Dynamics Study of Structural and Transport Properties of Silver Iodide Using Effective Charges

The superionic conductor, solid state, and body-centered cubic structure, silver iodide at room temperature, has been studied via molecular dynamics simulations. The calculated results using pairwise Coulomb-Buckingham potential, zero pressure on the sample, a semi-rigid model system of 1000 Ag and 1000 I ions, (NVE) as a statistical ensemble, and an effective charge of Z=0.63 for the pairs Ag-Ag and I-I, were found to be consistent with experimental data and one study using Z=0.60, different potential, and simulation software. For the pair Ag-I, there is a discrepancy due to the high silver ion diffusion. The calculated value of the diffusion constant of the silver ion is greater than iodide ion. The dynamic transport properties (mean square displacement, velocity autocorrelation function) results indicated typical behavior reported by other authors, using different potentials in their DM simulations for iodine and silver ions.     

The spectrum of additive BIB designs

In this article, the existence of additive BIB designs is discussed with direct and recursive constructions, together with investigation of a property of resolvability. Such designs can be used to construct infinite families of BIB designs. In particular, we obtain a series of B(sⁿ, ts^m, λt (ts^m ? 1) (s^n‐m ? 1)/[2(s^m ? 1)]) for any positive integer λ, such that sⁿ (sⁿ ? 1) λ ≡ 0 (mod s^m (s^m ? 1) and for any positive integer t with 2 ≤ t ≤ s^n‐m, where s is an odd prime power. Connections between additive BIB designs and other combinatorial objects such as multiply nested designs and perpendicular arrays are discussed. A construction of resolvable BIB designs with v = 4k is also proposed. © 2007 Wiley Periodicals, Inc. J Combin Designs 15: 235–254, 2007     

Some probabilistic properties of the nearest adjoining order method and its extensions

In this paper, some probabilistic properties of the nearest adjoining order (NAO) method are presented. They have been obtained under weaker assumptions than those commonly used, i.e. it is not assumed that comparisons are not independent and that probability of comparison errors are known. The results presented comprise the evaluation of the probability of obtaining an errorless solution with the use of the NAO method; asymptotic properties of this solution derived under the assumption that comparisons of different pairs (i.e. pairsx _i ,x _j andx _r ,x _r fori r,s andj r,s) are not correlated — for the case of one expert. An extension of results for the case ofN > 1 independent experts is also presented. This extension is accomplished by including an additional step — the aggregation of comparisons made by all experts for each pair of objects. Two ways of such an aggregation are analyzed: the averaging of experts' opinions and the majority principle. In the latter case, the result of the comparison is the same as the opinion of the majority of experts. The results obtained indicate an exponential convergence of the probability of the NAO solution to an errorless one in both cases. However, an application of the majority principle leads to a minimization problem, which is the same as in the case ofN = 1 and is much simpler than that corresponding to averaging of comparisons.     

Liquid-vapor equilibrium of dilute aqueous solutions of methanol

Numerous sets of vapor pressure-composition data for methanol in dilute aqueous solutions at 25°C and 35°C have been obtained with an automated vapor pressure apparatus developed in this laboratory. Activity coefficients of both components and values of the pairwise free energy of interaction of methanol molecules have been inferred from the results. The osmotic second virial coefficient of methanol has also been calculated and compared with literature values of this quantity.     

The Effects of Cyclodextrins on Hydrocortisone Permeability Through Semi-Permeable Membranes

Determinations of drug fluxes through semi-permeable cellophanemembranes are used to evaluate cyclodextrin complexes and cyclodextrin containingdrug formulations. In the present study we investigated how the cyclodextrin concentration,the membrane thickness and the molecular weight cut off (MWCO) of the membraneinfluence drug fluxes. The cyclodextrin used was 2-hydroxypropyl--cyclodextrin(HP--CD) and the sample drug was hydrocortisone. The MWCO ofthe membranes ranged from 500 to 14,000 and the HP--CD concentrationranged from 0 to 25% (w/v). The hydrocortisone flux from saturated solutions through the MWCO 500 membrane was unaffected by the cyclodextrin concentration. When MWCO of the membrane was greater than the molecular weight of the complex the flux fromsolutions saturated with hydrocortisone increased with increasing HP--CD concentration.This increase showed negative deviation from linearity. When the flux was correctedfor the viscosity increase with increasing HP--CD concentration then the fluxpattern could be described on the basis of Fick's first law and Stokes–Einsteinequation. However the flux did not correlate with the viscosity when it was increasedby adding polymer to the saturated drug solutions. It was shown that the observed fluxpattern was consistent with self-association of cyclodextrin complexes in the aqueousdonor phase.