Apis mellifera syriaca Venom: Evaluation of Its Anticoagulant Effect,Proteolytic Activity,and Cytotoxicity along with Its Two Main Compounds—MEL and PLA2—On HeLa Cancer Cells

Bee venom (BV) is one of the most remarkable natural products that has been a subject of studies since ancient times. Recent studies have shown that Apis mellifera syriaca venom possesses antibacterial as well as cytotoxic effects on cancer cell lines. The venom contains a variety of bioactive molecules—mainly melittin (MEL) and phospholipase A2 (PLA2), as well as other compounds that are not well characterized. In this work, we continue the biological characterization of A. mellifera syriaca venom by testing its anticoagulant effect on human plasma using the prothrombin time (PT) test, as well as assessing its proteolytic activity. In addition, the cytotoxicity of the crude venom—and of its two main components, MEL and PLA2—was tested on HeLa cancer cell lines for the first time. The results obtained showed the capacity of A. mellifera syriaca venom to increase clotting time, thereby proving its anticoagulant effect. Moreover, the venom did not demonstrate a significant proteolytic activity unless administrated at concentrations ≥ 5 mg/mL. Finally, we showed that crude A. mellifera syriaca venom, along with MEL, exhibit a strong in vitro cytotoxic effect on HeLa cancer cell lines, even at low concentrations. In summary, our findings could serve as a basis for the development of new natural-based drug candidates in the therapeutic field.     

掺杂对2H-MoTe2光电特性影响的第一性原理研究

MoTe₂是一种非空间反演对称性半导体,由线性偏振光照射,在无偏压条件下可以直接产生光电流,但是非常微弱.掺杂可以改变电子能带结构和降低空间反演对称性,从而有效的增强光电流.本文基于非平衡格林函数-密度泛函理论,采用第一性原理,计算了本征、Nb掺杂、Ti掺杂和W掺杂2H-MoTe₂的能带结构、透射谱和光电流.能带结构表明：Nb掺杂使半导体2H-MoTe₂能带穿越费米能级,转变为金属特性;Ti和W掺杂减小了2H-MoTe₂的带隙,能带没有穿越费米能级,依然为半导体.掺杂都降低2H-MoTe₂的反演对称对称性,从本征的D_3h转变为C_s.从而在线偏振光的照射下可以有效的提高2H-MoTe₂的光电流.同时,发现掺杂可以提高单层2H-MoTe₂在低光子能量下的消光比,如Nb和Ti掺杂单层2H-MoTe₂分别在光子能量1.1 eV和1.2 eV处取得39.48和28.48的高消光比...     

Effects of the Low Frequencies of Noise on On–Off Intermittency

A bifurcating system subject to multiplicative noise can exhibit on–off intermittency close to the instability threshold. For a canonical system, we discuss the dependence of this intermittency on the Power Spectrum Density (PSD) of the noise. Our study is based on the calculation of the Probability Density Function (PDF) of the unstable variable. We derive analytical results for some particular types of noises and interpret them in the framework of on-off intermittency. Besides, we perform a cumulant expansion (N. G. van Kampen, 24, 171 (1976).) for a random noise with arbitrary power spectrum density and we show that the intermittent regime is controlled by the ratio between the departure from the threshold and the value of the PSD of the noise at zero frequency. Our results are in agreement with numerical simulations performed with two types of random perturbations: colored Gaussian noise and deterministic fluctuations of a chaotic variable. Extensions of this study to another, more complex, system are presented and the underlying mechanisms are discussed. PACS Number: 05.40.-a, 05.45.-a, 91.25.-r     

高峰值功率大模场全光纤脉冲放大器

报道了一种由纤芯直径分别为15 μm和25 μm的大模场光纤组成的全光纤脉冲放大器模块。当注入脉冲宽度为10 ns,重复频率为1 Hz,光谱宽度为0.3 nm,脉冲能量为80 nJ的激光脉冲时,经过两级放大输出的激光脉冲峰值功率为30 kW,单脉冲能量为300 μJ。此外,实验研究了该放大器模块输出的时间特性。研究发现：由于受激布里渊散射（SBS）效应,限制了单纵模光纤激光在光纤中的高能量放大,采用宽带激光脉冲可以有效地抑制SBS效应,提高光纤放大器的SBS阈值。     

应用数码照相技术分析塞曼分裂图谱

讨论了现有塞曼效应实验成像方法的不足;介绍一种用普通数码照相机进行拍摄和计算机程序处理技术研究塞曼效应的方法.     

Quantum anomalous Hall effect and giant Rashba spin-orbit splitting in graphene system co-doped with boron and 5d transition-metal atoms

Quantum anomalous Hall effect (QAHE) is a fundamental quantum transport phenomenon in condensed matter physics. Until now, the QAHE has only been experimentally realized for Cr/V-doped (Bi, Sb)₂Te₃ but at an extremely low observational temperature, thereby limiting its potential application in dissipationless quantum electronics. By employing first-principles calculations, we study the electronic structures of graphene co-doped with 5d transition metal and boron atoms based on a compensated n–p co-doping scheme. Our findings are as follows: i) The electrostatic attraction between the n- and p-type dopants effectively enhances the adsorption of metal adatoms and suppresses their undesirable clustering. ii) Hf-B and Os-B co-doped graphene systems can establish long-range ferromagnetic order and open larger nontrivial band gaps because of the stronger spin-orbit coupling with the non-vanishing Berry curvatures to host the high-temperature QAHE. iii) The calculated Rashba splitting energies in Re–B and Pt–B co-doped graphene systems can reach up to 158 and 85 meV, respectively, which are several orders of magnitude higher than the reported intrinsic spin-orbit coupling strength.     

Collective current rectification

We consider a set of coupled underdamped ac-driven dynamical units exposed to a heat bath. The coupling scheme defines the absence/presence of certain symmetries, which in turn cause a nonzero/zero value of a mean dc-output. We discuss dynamical mechanisms of a dc-current appearance and identify current reversals with synchronization/desynchronization transitions in the collective ratchet's dynamics.     

Structure and magnetocaloric properties of La1−xKxMnO3 manganites

A technology of obtaining the single-phase ceramic samples of La_1−xK_xMnO₃ manganites and the dependence of their structural parameters on the content of potassium has been described. Magnetocaloric effect (MCE) in the obtained samples has been measured by two independent methods: classical direct methodic and a method of magnetic field modulation. The values of MCE obtained by both methods substantially differ. The explanation of the observed divergences is given. The correlation between the level of doping and MCE value has been defined. The value of T_C determined by the MCE maximum conforms with the literature data obtained by other methods.     

顺磁性物质CeF3中磁化率和费尔德常数的定量计算

本文首先计及晶场对顺磁性物质CeF_3中Ce~(3+)离子4f基态和5d激发态能级的影响,进而考虑了间接交换作用有效场II_v和外磁场H_e共同作用下导致的晶场基态能级的进一步分裂,然后应用基态双能级跃迁模型定量计算了CeF_3中的比法拉第旋转θ_F,费尔德常数F和磁化率X以及它们与温度的依赖关系.计算表明,CeF_3中的磁光效应及其温度特性与Ce~(3+)离子之间的间接交换作用密切相关,在60相似文献