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121.
122.
稀土对人正常肝细胞株7701和人宫颈癌Hela细胞生长的影响及其诱导细胞凋亡的作用 总被引:2,自引:5,他引:2
采用MTT法考察了16种稀土元素在9×10-8~2×10-4mol.L-1浓度范围内对体外培养的人正常肝细胞株7701细胞和宫颈癌Hela细胞的生长的影响。结果表明,稀土对细胞生长的影响存在浓度依赖性;低浓度促进细胞增殖,高浓度抑制细胞生长;不同稀土离子对细胞作用强弱不同,稀土间存在轻重分组效应;不同细胞对稀土的响应不同,表现出稀土对正常细胞和癌细胞作用的某种选择性。Hoechst 33258标记细胞DNA,用激光共聚焦显微镜和流式细胞仪对稀土处理的肝细胞株7701进行形态学观察和DNA含量分析。结果表明,较高浓度的稀土作用后的肝细胞株7701出现了明显的凋亡特征,稀土表现出的细胞毒性作用,其本质是诱导细胞发生凋亡。 相似文献
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124.
For the fist time the preparation of a mostly solid-state high efficiem electro-conductive material comprising 1-methyl-3-propylimidazolium iodide (MPII), benzimidazole (BI), iodine and lithium iodide was reported. In this electrolyte, BI acts as not only additives but also gelators. With its significant electrochemical properties, an overall efficiency of 3.07% was achieved under AM 1.5 (100 mW/cm^2). 相似文献
125.
Cilia of hair cells are structurally similar to unilaminar phospholipid vesicles. The close juxtaposition of adjacent cilia is similar to the intervesicle distances found in groups of vesicles. Both cilia and vesicles operate in similar ionic environments. By comparing the cross section of cilia, which are cylinders with the cross section of vesicles, which are spherical, we can see how colloid theory can be applied to both cilia and vesicles. While vesicles have been studied as colloid particles, thus far colloid theory has not been applied to hair cell cilia. This paper presents a basic explanation of colloid theory in a simple graphic form that facilitates a colloid perspective of hair cell cilia behavior. A review of relevant hair cell cilia behavior supports the hypothesis that colloid knowledge is applicable to the problem of understanding cilia functionality in the hair cell. The electromagnetic nature of colloid forces allows for their involvement in the relatively high speed operation required of hair cells which are dealing with signals of up to 2×105 Hz. A fresh look at the biophysics of the hair cell from a colloid perspective may lower the barrier to a closer understanding of active mechanical sensory transduction, amplification and adaptation, and suggest a new domain for the application of colloid theory. 相似文献
126.
Natural products of the medicinal fungus Ganoderma lucidum: occurrence,biological activities,and pharmacological functions 总被引:1,自引:0,他引:1
Shiao MS 《Chemical record (New York, N.Y.)》2003,3(3):172-180
Ganoderma lucidum, a fungus used in traditional Chinese medicine, produces polysaccharides and oxygenated triterpenoids with a very broad spectrum of biological activities and pharmacological functions. Among the Ganoderma triterpenoids, many pairs of C-3 alpha/beta stereoisomers and C-3/C-15 positional isomers have been identified. Biosynthetic study has indicated that the C-3alpha series of oxygenated triterpenoids is derived from the C-3beta series via an oxidation-reduction pathway. The interaction of Ganoderma triterpenoids with human platelets in the induction of aggregation and inhibition of agonist-induced aggregation and signal transduction has been elucidated. Reduction of cellular mevalonate content to a stage in which cholesterol synthesis is strongly inhibited and cell growth is marginally arrested sensitizes hepatoma cells to the oxygenated triterpenoids. A combination treatment of lovastatin and Ganoderma triterpenoids in animal studies has exhibited a potential anticancer effect. 相似文献
127.
Hayley A. Every Michael A. Hickner James E. McGrath Thomas A. Zawodzinski Jr. 《Journal of membrane science》2005,250(1-2):183-188
Methanol diffusion in two polymer electrolyte membranes, Nafion 117 and BPSH 40 (a 40% disulfonated wholly aromatic polyarylene ether sulfone), was measured using a modified pulsed field gradient NMR method. This method allowed for the diffusion coefficient of methanol within the membrane to be determined while immersed in a methanol solution of known concentration. A second set of gradient pulses suppressed the signal from the solvent in solution, thus allowing the methanol within the membrane to be monitored unambiguously. Over a methanol concentration range of 0.5–8 M, methanol diffusion coefficients in Nafion 117 were found to increase from 2.9 × 10−6 to 4.0 × 10−6 cm2 s−1. For BPSH 40, the diffusion coefficient dropped significantly over the same concentration range, from 7.7 × 10−6 to 2.5 × 10−6cm2 s−1. The difference in diffusion behavior is largely related to the amount of solvent sorbed by the membranes. Increasing the methanol concentration results in an increase in solvent uptake for Nafion 117, while BPSH 40 actually excludes the solvent at higher concentrations. In contrast, diffusion of methanol measured via permeability measurements (assuming a partition coefficient of 1) was lower (1.3 × 10−6 and 6.4 × 10−7 cm2 s−1 for Nafion 117 and BPSH 40 respectively) and showed no concentration dependence. The differences observed between the two techniques are related to the length scale over which diffusion is monitored and the partition coefficient, or solubility, of methanol in the membranes as a function of concentration. For the permeability measurements, this length is equal to the thickness of the membrane (178 and 132 μm for Nafion 117 and BPSH 40 respectively) whereas the NMR method observes diffusion over a length of approximately 4–8 μm. Regardless of the measurement technique, BPSH 40 is a greater barrier to methanol permeability at high methanol concentrations. 相似文献
128.
Summary A packed flow cell was used for fluorometric detection in micro high-performance liquid chromatography. The flow cell consisted of fused-silica tubing packed with the same material as the separation column. A focusing effect of the stationary phase on the signal intensity was observed, leading to an improvement of the mass detection limit, as achieved by on-column detection. 相似文献
129.
Benzathine is prepared in good yields from cyanobenzene by a combination of electrochemical hydrogenation and Kolbe electrolysis using nickel and platinum electrodes in the presence of methanolic sodium methoxide in an undivided cell. 相似文献
130.
Nasib Qureshi Patrick Karcher Michael Cotta Hans P. Blaschek 《Applied biochemistry and biotechnology》2004,114(1-3):713-721
Corn steep liquor (CSL), a byproduct of the corn wet-milling process, was used in an immobilized cell continuous biofilm reactor
to replace the expensive P2 medium ingredients. The use of CSL resulted in the production of 6.29 g/L of total acetone-butanol-ethanol
(ABE) as compared with 6.86 g/L in a control experiment. These studies were performed at a dilution rate of 0.32 h−1. The productivities in the control and CSL experiment were 2.19 and 2.01 g/(L·h), respectively. Although the use of CSL resulted
in a 10% decrease in productivity, it is viewed that its application would be economical compared to P2 medium. Hence, CSL
may be used to replace the P2 medium. It was also demonstrated that inclusion of butyrate into the feed was beneficial to
the butanol fermentation. A control experiment produced 4.77 g/L of total ABE, and the experiment with supplemented sodium
butyrate produced 5.70 g/L of total ABE. The butanol concentration increased from 3.14 to 4.04 g/L. Inclusion of acetate in
the feed medium of the immobilized cell biofilm reactor was not found to be beneficial for the ABE fermentation, as reported
for the batch ABE fermentation.
Names are necessary to report factually on available data. However, the USDA neither guarantees nor warrants the standard
of the product, and the use of the names by USDA implies no approval of the product to the exclusion of others that may also
be suitable. 相似文献