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21.
Determination of Iron(II) in Pharmaceuticals Using Chlorpromazine Hydrochloride as a Redox Indicator
《Analytical letters》2012,45(15):3003-3009
Abstract Titrimetric method for the determination of (1–100) mg/L iron(II) as pure solutions and in its dosage forms was investigated and found to offer an improvement in ease, speed and accuracy. This method is based on the direct visual titration of iron(II) with ceric amnonium sulphate and employs chlorpromazine hydrochloride in a mixture of sulphuric and phosphoric acids as a redox indicator. An interference study is carried out for the differant acids and cations. Data obtained for sevceral pharmaceuticals are reported and compared with those obtained potentiometrically. Formal redox potential was determined to be 285 mv. 相似文献
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《Analytical letters》2012,45(6):355-358
Abstract Two methods are described for the determination of sulphate in the range of 200 μg to 100 mg by dissolving precipitated barium sulphate in excess of EDTA at pH 12.5. A titrimetric procedure involves back titration of excess EDTA with a standard zinc solution, while a complementary spectrophotometric method makes use of the stability of the barium EDTA complex in the presence of an excess of zinc ions; the latter are reacted with zincon and are equivalent to the amount of sulphate present. 相似文献
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以氢离子选择性电极为工作电极,盐酸或氢氧化钠为滴定剂,用多元校正滴定法对酒石酸美托洛尔片的含量进行了测定。探讨了盐酸或氢氧化钠测定酒石酸美托洛尔的可行性,比较了过滤和不过滤两种方法配制试液的测定结果。本法测定结果与中国药典(1995)中非水滴定法的对照偏差在1%之内;采用过滤和不过滤两种方法配制的试液测定结果之间的偏差在0.2%之内。 相似文献
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卡尔费休滴定法测定液体推进剂混胺燃料中水分 总被引:1,自引:0,他引:1
液体推进剂混胺燃料中作为主要组分存在的三乙胺使其显示较高的碱性,对用卡尔费休滴定法测定其水分含量时产生干扰。提出了在试样的甲醇滴定介质中加入一定量的乙酸,保持液体混胺试样和乙酸的体积比小于或等于3比5,达到使滴定介质的酸度控制在最佳pH范围5~6之间。经此操作,由三乙胺的高碱度引起的干扰可消除。对已知水分含量的混胺试样按方法进行分析,算得其水分测定值的相对标准偏差(n=12)为2.1%。取不同批号的混胺试样7件,按方法进行分析并用标准气量法对结果进行校核。两种方法测定结果的相对偏差在-0.023%~0.033%之间。又根据t-检验法的结果认定,两方法所得测定值之间不存在显著差异。 相似文献
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Two simple, fast, accurate and precise methods for the determination of six phenothiazines and a number of their pharmaceutical
formulations are described. The titrimetric method involves the oxidation of the drugs by metavanadate in sulphuric acid medium
and titration of vanadium(IV) formed, with cerium(IV) using ferroin indicator and acetone as catalyst. In spectrophotometry,
vanadium(IV) formed was reacted with ferriin and the resulting ferroin measured at 510 nm. Phenothiazines in the ranges 5–100 mg
and 2.5–25.0 μg mL−1 can be determined by titrimetry and spectrophotometry, respectively, with detection limits of 0.96–2.05 mg and 0.0359–0.0565 μg mL−1, respectively. Both methods were applied successfully to the determination of the studied drugs in pharmaceutical preparations.
The reliability of the assays was established by parallel determination by the official methods of British Pharmacopoeia and
the results being statistically evaluated.
Received September 26, 2000. Revision March 25, 2001. 相似文献
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铁(Ⅲ)的滴定计算分析法测定 总被引:2,自引:0,他引:2
在Fe^2 存在的条件下,以铂电极为指示电极、Ce^4 标准溶液为滴定剂,对氧化还原滴定计算分析法测定Fe^3 进行了研究。结果表明,电极的系统误差是影响结果准确度的主要因素。 相似文献
30.
建立了硫酸铁铵滴定法测定钨钛合金中钛含量的新方法。以硝酸-氢氟酸溶解样品,在25mL NaOH(100g/L)的强碱性介质中,以铁为载体,沉淀分离被测定元素钛后,用盐酸溶解沉淀。在酸性条件下,用铝片还原Ti~(4+)至Ti~(3+),以硫氰酸盐为指示剂,用硫酸铁铵标准溶液滴定至红色为终点。根据消耗硫酸铁铵滴定溶液的体积,求得样品中钛含量。按照实验方法测定样品中钛含量,结果的相对标准偏差(RSD,n=11)为0.40%,加标回收率为99.8%~101%。方法有很好的精密度和准确度,可用于钨钛合金中钛含量的分析。 相似文献