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31.
Base mediated deprotection strategies for trifluoroethyl (TFE) ethers,a new alcohol protecting group
A trifluoroethyl (TFE) ether is specifically introduced as a protecting group in organic chemistry. Its first strategic application and removal in the total synthesis of vinigrol is discussed. Two lithium base mediated deprotection strategies for its removal are presented in this Letter. In one deprotection approach, the trifluoroethyl ether is converted to a difluorovinyl ether and then catalytically cleaved using osmium tetraoxide, while in the second approach a difluorovinyl anion is formed and trapped with an electrophilic oxygen reagent (MoOPH) to form a labile difluoroacetate. To further aid the reader, a summary of approaches for forming trifluoroethyl ethers is included as well as a discussion of alternate deprotection strategies. 相似文献
32.
A facile synthesis of C17α-OH-tigogenin, the aglycon of aspafiliosides E and F, is described. The crucial step is the spiroketal-forming cascade, which forms the rings EF in one step and provides a new strategy for spiroketal ring closure in steroidal sapogenins and other substrates. This synthesis minimizes redundant oxidation-reduction manipulations of previous syntheses. 相似文献
33.
A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-(-)-malic acid. The key steps involve substitution cyclization reaction and RCM reaction to construct the aza fused bicyclic framework. 相似文献
34.
Luiz C. Dias Ilton B.D. de Castro Leonardo J. Steil Tatiana Augusto 《Tetrahedron letters》2006,47(2):213-216
The dihydroxylation of unsaturated aldol adducts with catalytic OsO4 and NMO occurs under very mild conditions and with moderate to excellent levels of diastereoselectivity to give trisubstituted γ-butyrolactone derivatives. 相似文献
35.
Bapurao B. Shingate Braja G. Hazra Deepak B. Salunke Vandana S. Pore Fazal Shirazi Mukund V. Deshpande 《Tetrahedron》2013,69(52):11155-11163
Chemically diverse oxysterols and their synthetic manipulations were carried out from variety of Δ8(9)-lanosterol derivatives and evaluated for their in vitro antimicrobial activities. Most of the synthesized oxysterols exhibited significant antifungal activity against the tested strains. 相似文献
36.
G.V.M. Sharma Nagendar Pendem Palakodety Radha Krishna A.C. Kunwar 《Tetrahedron letters》2004,45(48):8807-8810
The stereoselective synthesis of 4′-deoxy aza-disaccharides in a concise and practical approach is described from C-linked carbo-β-amino acid esters and this protocol utilizes an intramolecular amide bond formation and cis-dihydroxylation for the construction of the new sugar ring. 相似文献
37.
Substituted 3-amino-4-aryl-4-hydroxypiperidines and 4-aryl-3,4-dihydroxypiperidines are synthesized in the modest overall yields starting from the regio- and stereoselective trans-aminohydroxylation and dihydroxylation of 4-aryl-1,2,5,6-tetrahydropyridines via CAN-mediated oxidative addition and hydrogenation. 相似文献
38.
Mikael Johansson 《Journal of organometallic chemistry》2005,690(15):3614-3619
Room temperature ionic liquid [bmim]PF6 was used to immobilize a bimetallic catalytic system for H2O2-based dihydroxylation of alkenes. Osmium tetroxide was used as the substrate-selective catalyst with either VO(acac)2 or MeReO3 as co-catalyst. The latter serve as an electron transfer mediator (ETM) and activates H2O2. For an increased efficiency N-methylmorpholine is required as an additional ETM in most cases. A range of alkenes were dihydroxylated using this robust bimetallic system and it was demonstrated that for some of the alkenes the catalytic system can be recycled and used up to five times. 相似文献
39.
Synthesis of the highly substituted polyoxygenated tetrahydropyran ring of botcinic acid, the revised structure of botcinolide is achieved using, as key steps, a highly stereoselective aldol reaction of the titanium enolate from a lactate-derived chiral ketone and a stereoselective dihydroxylation. 相似文献
40.
Michael A. Oakley Simon Woodward Keith Coupland David Parker Clare Temple-Heald 《Journal of molecular catalysis. A, Chemical》1999,150(1-2):105-111
Unsaturated fatty acids [C8H17CH=CH(CH2)nCO2H] (n=7, 11) acids are cleanly dihydroxylated by hydrogen peroxide in the presence of catalytic amounts of H2WO4. Under molecular oxygen, in the presence of catalytic amounts of N-hydroxyphthalimide and Co(acac)3, the diols resulting from erucic (n=11) and oleic (n=7) acid undergo C–C cleavage. 相似文献