Current perspectives on benzoflavone analogues with potent biological activities: A review

Medicinal chemistry investigators have isolated and synthesized benzoflavone analogues with diverse bioactivities including enzyme inhibitory activity, central nervous system (CNS) activity, anti-inflammatory activity, anti-microorganism activity, hypoglycemic activity, and receptor modulating potential. SAR (Structure-Activity Relationship) studies have been conducted extensively and plenty of benzoflavone analogues have been prepared for potential targets. Herein, we review the pharmacology properties and SAR for benzoflavone analogues, and provide a brief summarization of synthetic strategies, wishing to give perspective on the research and development of benzoflavone derivatives.     

欧芹酚甲醚腙类衍生物的合成及抗乙酰胆碱酯酶活性研究

以香豆素类化合物欧芹酚甲醚为先导化合物,设计合成了15个欧芹酚甲醚腙类衍生物,所有目标化合物经熔点、¹H NMR和MS进行结构确证。体外抑制乙酰胆碱酯酶活性结果表明,在100μmol/L浓度下,目标化合物3d对乙酰胆碱酯酶具有较强的抑制活性,其抑制率达到66.1%。初步构效关系表明,在欧芹酚甲醚腙类化合物的苯环上引入斥电子基能提高对乙酰胆碱酯酶的抑制活性。分子对接表明化合物3d可以和乙酰胆碱酯酶的催化活性中心部位显著结合。     

Advances and challenges of MOF derived carbon-based electrocatalysts and photocatalyst for water splitting: A review

Environmental pollution and energy shortage are substantial fears to the modern world's long-term sustainability. Water splitting is an essential technique for eco - friendly and sustainable energy storage, as well as a pollution-free method to produce hydrogen. In this regards Metal–organic frameworks have emerged as the most competent multifunctional materials in recent times, due to its large surface areas, adjustable permeability, easy compositional alteration, and capability for usage as precursors with a wide range of morphological forms. Further, MOF-derived carbon-based nanomaterials also offer significant benefits in terms of tunable morphological features and hierarchical permeability, as well as ease of functionalization, making them extremely effective as catalysts or catalysts supports for a wide variety of important reactions. Recent developments in carbon-based MOFs as catalysts for overall water splitting are discussed in this review. We explore how MOFs and carbon-based MOFs might well be beneficial, as well as which methods should be explored for future development. We divided our review into two sections: photocatalytic and electrocatalytic water splitting, and we gathered published literature on carbon-based MOFs materials for their outstanding activity, offers helpful methods for catalysts design and analysis, as well as difficulties This study highlights the developments in MOF derived materials as photo and electro catalysts by explaining respective approaches for their use in overall water splitting.     

由分数次导数所确定的L2(T)中的一元周期函数类在Lq(T)中的相对宽度

作者研究了相对宽度K_n(W₂^α(T), MW₂^β(T), L₂(T)), T=[0,2π], 确定了使等式K_n(W₂^α(T), MW₂^β(T), L₂(T))=d_n(W₂^α(T), L₂(T))成立的最小M值, 得到了相对宽度K_n(W₂^α(T), W₂^α(T), L_q(T))的渐近阶, 其中α≥β>0, 1≤q≤∞, K_n(., ., L_q(T)) 和 d_n(., L_q(T))分别表示Kolmogorov意义下L_q(T)尺度下的相对宽度和宽度, MW_p^α(T), 1≤ p≤∞, 表示有如下卷积表达式的2π 周期函数类, f(t)=c+(B_α* g)(t),c∈ R, B_α*g 表示 B_α 和g 的卷积, g∈L_p(T) 满足∫₀^2πg(τ)dτ=0 和||g||_p≤M, B_α∈ L₁(T) 有如下Fourier展开: B_α(t)=1/2π∑' _{k∈ Z}(ik)^-αe^ikt,∑^'表示去掉 k=0的项.     

Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

<正>Solasodine 11 is a steroidal alkaloid with various biological activities.Herein,8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro.Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs.In particular,19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line(IC_(50) = 3.91μmol/L).     

甲壳质、甲壳胺衍生物保护的贵金属胶体

<正> 高分子保护金属胶体是近年来金属催化剂领域中引人注目的研究课题。它除了具有负载型金属催化剂的优点外,还具备下列新优点:a.胶体分散体系可形成“均相”溶液;b.保护高分子可以屏蔽胶体催化剂,减小毒物或空气的不良影响;c.胶体溶液的透光性能比颗粒要好得多,由此最近高分子保护金属胶体常被用于光化学研究中的催化剂;d.高分子保护金属胶体与普通金属胶体相比较,不仅具有较稳定的特点,而且尺寸小(1—10nm)、分布窄,表现出极高的催化活性和选择性;e.保护高分子对金属的修饰作用,可     

Asymmetrische Katalysen, 73. Mitt. Enantioselektive Decarboxylierung von Methylphenylmalonsäure-Derivaten mit Cu(I)/Alkaloid-Katalysatoren

Summary Methylphenylmalonic acid was decarboxylated to yield 2-phenylpropionic acid with an optical induction of 36% ee using catalytic amounts of CuCl and an excess of (+)-cinchonine in acetonitril. Methylphenylmalonic acid hemiethylester gave ethyl 2-phenylpropionate of 20% ee with catalytic amounts of CuCl and (+)-cinchonine, respectively. The tetraethylammonium salt of methylphenylmalonic acid could be decarboxylated in the presence of CuCl, (+)-cinchonine, and chiral carboxylic acids, the best result of 27% ee being obtained with malic acid.

     

The synthesis of functional derivatives of the [1-CB9H10] anion by Brellochs reaction

Reactions of decaborane with various aldehydes in alkaline media were studied. The reactions with HCOH and 2-MeOC₆H₄CHO give the corresponding arachno-carboranes [6-R-arachno-CB₉H₁₃]⁻ (R = H, C₆H₄-2-OMe), whereas the reactions with C₆H₅CHO, 4-BrC₆H₄CHO, 4-MeCONHC₆H₄CHO, and 2-SC₄H₃CHO result in the nido-carboranes [6-R-nido-CB₉H₁₁]⁻ (R = C₆H₅, C₆H₄-4-Br, C₆H₄-4-NHCOMe, 2-SC₄H₃). Both the arachno- and nido-carboranes can be easily oxidized with elemental iodine in an alkaline aqueous solution giving the corresponding closo-derivatives [2-R-closo-2-CB₉H₉]⁻. These closo-2-isomers, under heating in solution, undergo rearrangement to more thermodynamically favorable closo-1-isomers [1-R-closo-1-CB₉H₉]⁻. The structure of (Bu₄N)[1-(4-BrC₆H₄)-1-CB₉H₉] was determined using single crystal X-ray diffraction.