5-Aza-2′-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line

It is well-recognized that DNA methylation and histone modifications play critical roles in epigenetic regulation of gene activity through the alteration of chromatin structure. Recent studies have shown that in a subset of cancer cells, the silencing of the human E-cadherin (CDH1) gene is associated with hypermethylation of the CpG island. However, the associated molecular mechanism remains unclear. To understand the mechanism, we have investigated the alteration of CpG island methylation and histone modifications during the reactivation of the CDH1 gene by treatment with 5-aza-2′-deoxycytidine (5-aza-dC). Although the CDH1 gene expression was recovered by treatment with 5-aza-dC in a liver cancer cell line Li21, the methylation status of the entire CpG island and acetylation and methylation status of associated histones were not significantly altered. These results demonstrate that the silenced CDH1 gene can be reactivated without apparent alteration of histone modification or CpG island methylation.     

Systems of generalized quasivariational inclusions problems with applications to variational analysis and optimization problems

In this paper, we study an existence theorem of systems of generalized quasivariational inclusions problem. By this result, we establish the existence theorems of solutions of systems of generalized equations, systems of generalized vector quasiequilibrium problem, collective variational fixed point, systems of generalized quasiloose saddle point, systems of minimax theorem, mathematical program with systems of variational inclusions constraints, mathematical program with systems of equilibrium constraints and systems of bilevel problem and semi-infinite problem with systems of equilibrium problem constraints. This research was supported by the National Science Council of the Republic of China.     

Constructing orthogonal pandiagonal Latin squares and panmagic squares from modular n‐queens solutions

In this article, we show how to construct pairs of orthogonal pandiagonal Latin squares and panmagic squares from certain types of modular n‐queens solutions. We prove that when these modular n‐queens solutions are symmetric, the panmagic squares thus constructed will be associative, where for an n × n associative magic square A = (a_ij), for all i and j it holds that a_ij + an?i?1,n?j?1 = c for a fixed c. We further show how to construct orthogonal Latin squares whose modular difference diagonals are Latin from any modular n‐queens solution. As well, we analyze constructing orthogonal pandiagonal Latin squares from particular classes of non‐linear modular n‐queens solutions. These pandiagonal Latin squares are not row cyclic, giving a partial solution to a problem of Hedayat. © 2007 Wiley Periodicals, Inc. J Combin Designs 15: 221–234, 2007     

Generators of some Ramanujan formulas

In this paper we prove some Ramanujan type formulas for 1/π but without using the theory of modular forms. Instead we use the WZ—method created by H. Wilf and D. Zeilberger and find some hypergeometric functions in two variables which are second components of WZ—pairs than can be certified using Zeilberger's EKHAD package. These certificates have an additional property which allows us to get generalized Ramanujan's type series which are routinely proven by computer. We call these second hypergeometric components of the WZ—pairs generators. Finding generators seems a hard task but using a kind of experimental research (explained below), we have succeeded in finding some of them. Unfortunately we have not found yet generators for the most impressive Ramanujan's formulas. We also prove some interesting binomial sums for the constant 1/π². Finally we rewrite many of the obtained series using pochhammer symbols and study the rate of convergence. 2000 Mathematics Subject Classification Primary—33C20     

X-ray metrology for advanced silicon processes

X-ray reflectivity (XRR), X-ray fluorescence (XRF) and small angle X-ray scattering (SAXS) techniques are used to the monitoring of Cu/porous low κ processes, which are developed for the next generation (≤65 nm) integrated circuits. Sensitivity of XRR and XRF is sufficient to detect drifts of the copper barrier layer, copper seed layer and Cu CMP (chemical-mechanical polishing) processes. Their metrology key parameters comply with production requirements. SAXS allows determining the pore structure of low κ films: average pore size and pore size distribution.     

Density functional theory study on antiferromagnetic interactions in a silver (I) complex of nitronyl nitroxide

A one-dimensional (1D) silver (I) complex of nitronyl nitroxide with fairly strong antiferromagnetic interaction, in which the metal ions are diamagnetic, is investigated by means of the ab initio crystal orbital method based on the density functional theory. The calculated values of the magnetic coupling constant (J) are close to the experimental measured J value in the periodic system. The magneto-structural correlation reveals that the existence of an antiferromagnetic coupling pathway along nitronyl nitroxide units via silver (I) ion in this system. The spin population distribution also shows the existence of spin delocalization along the ONCNO–Ag–ONCNO, which affords a rational interpretation for the antiferromagnetic interaction mechanism.     

On solving energy-dependent partitioned eigenvalue problem by genetic algorithm: The case of real symmetric Hamiltonian matrices

An energy-dependent partitioning scheme is explored for extracting a small number of eigenvalues of a real symmetric matrix with the help of genetic algorithm. The proposed method is tested with matrices of different sizes (30 × 30 to 1000 × 1000). Comparison is made with Löwdin’s strategy for solving the problem. The relative advantages and disadvantages of the GA-based method are analyzed     

Ba(Zr0.3Ti0.7)O3 铁电薄膜的制备

介绍了用溶胶-凝胶法(sol-gel)在Pt/Ti/SiO2/Si衬底和石英衬底上制备Ba(Zr0.3Ti0.7)O3铁电薄膜的基本原理、工艺过程及工艺特点;Sol-gel制备的Ba(Zr0.3Ti0.7)O3铁电薄膜表面平整、厚度均匀.