PEGylated inorganic nanoparticles

Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.     

Kinetic Magnetic‐Field Effect Involving the Small Biologically Relevant Inorganic Radicals NO and O2.−

Oxidation of dihydrorhodamine 123 (DHR) to rhodamine 123 (RH) by oxoperoxonitrite (ONOO^?), formed through recombination of NO and O₂^.? radicals resulting from thermal decomposition of 3‐morpholinosydnonimine (SIN‐1) in buffered aerated aqueous solution at pH 7.6, represents a kinetic model system of the reactivity of NO and O₂^.? in biochemical systems. A magnetic‐field effect (MFE) on the yield of RH detected in this system is explored in the full range of fields between 0 and 18 T. It is found to increase in a nearly linear fashion up to a value of 5.5±1.6 % at 18 T and 23 °C (3.1±0.7 % at 40 °C). A theoretical framework to analyze the MFE in terms of the magnetic‐field‐enhanced recombination rate constant k_rec of NO and O₂^.? due to magnetic mixing of T₀ and S spin states of the radical pair by the Δg mechanism is developed, including estimation of magnetic properties (g tensor and spin relaxation times) of NO and O₂^.? in aqueous solution, and calculation of the MFE on k_rec using the theoretical formalism of Gorelik at al. The factor with which the MFE on k_rec is translated to the MFE on the yield of ONOO^? and RH is derived for various kinetic scenarios representing possible sink channels for NO and O₂^.?. With reasonable assumptions for the values of some unknown kinetic parameters, the theoretical predictions account well for the observed MFE.     

DNA/羟基磷灰石杂化膜修饰电极用于研究DNA与量子点的相互作用

首次利用溶胶-凝胶一步法制备了纳米多孔羟基磷灰石(HAp)-DNA杂化膜修饰玻碳电极,HAp优良的生物相容性和独特的吸附性可以将DNA固定在HAp多孔薄膜上,而DNA的大分子结构对HAp膜起到稳定剂的作用.采用循环伏安法和交流阻抗法系统地研究了电极表面固定DNA的稳定性以及固定的DNA与非电活性核壳型量子点CdTe/C...     

Unsteady generalized Couette flow in composite microchannel

A numerical study is reported on the fully developed unsteady laminar fluid flow in microchannel parallel-plates partially filled with a uniform porous medium and partially filled with a clear fluid. The flow is induced by the movement of one of the plates and the pressure gradient. The Brinkman-extended Darcy model is utilized to model the flow in the porous region, while the Stokes equation is used in the clear fluid region. A theoretical analysis is also presented for the fully developed steady flow to find closedform expressions for the interfacial velocity and the velocity and skin frictions at the bounding plates. Numerical computations shows excellent agreement between the closedform solutions for fully developed steady flow and the numerical solution to unsteady flow at large values of time.     

Lamb波在复合材料板中传播的谱有限元模拟

众所周知Lamb波在复合材料中的传播呈各向异性的特点,经典有限元法模拟这类问题效率不高,所以,本文采用谱有限元法进行研究。先建立了一种新的谱有限板单元,该单元以Gauss-Lobatto-Legendre点作为节点,使质量矩阵是对角矩阵;另外,该单元采用了扩展的位移场,能够较好地模拟板结构的三维特性。然后,对复合材料板结构中Lamb波在对称模式与反对称模式下的传播速度进行了求解,将计算结果与Mindlin板谱单元的结果以及三维弹性理论的结果进行了比较,并讨论了Lamb波在反对称层合板中的传播特点。最后,模拟了Lamb波在含和不含损伤复合材料层合板中的传播,数值结果表明所建立的谱有限板单元可以较好地模拟出Lamb波在复合材料板结构中的传播特性。     

复合功能布的动态力学性能及本构关系

针对复合功能布的物理特性,利用材料试验机和分离式Hopkinson压杆装置,展开了准静态和动态条件下单层和双层复合功能布材料的单轴抗压实验,获得了两种材料在不同应变率下的应力应变曲线和材料的失效应力、应变.实验结果表明:复合功能布的动态失效强度明显高于准静态失效强度,而且随着应变率的增加其动态失效强度呈现增加的趋势,即该材料具有明显的应变率硬化效应.对应力应变曲线进行拟合,给出了材料的动静态粘弹性本构关系.并对复合功能布在不同应变率下的失效应变及材料的损伤结果进行了初步的分析.     

Analytical study of the interface in fibre-reinforced 2D composite material

Imperfect bonding between the constitutive components can greatly affect the properties of the composite structures.An asymptotic analysis of different types of imperfect interfaces arising in the problem of 2D fibrereinforced composite materials are proposed.The performed study is based on the asymptotic reduction of the governing biharmonic problem into two harmonic problems.All solutions are obtained in a closed analytical form.The obtained results can be used for the calculation of pull-out and pushout tests,as well as for the investigation of the fracture of composite materials.