CdSe_xTe_(1-x)薄膜的光电化学研究

用涂敷法制备了Cdse_xTe_(1-x)薄膜电极0.8>x>0.4,其组成和结构用X射线衍射及X射线荧光光谱进行分析。对薄膜电极的光电化学性能,转换效率,能隙与x的依赖关系进行了研究。通过烧结工艺的改进,获得光电转换效率高于12％的薄膜电极。     

Styrene Butadiene Rubber/Silicone Rubber Blends Filled With Dough Moulding Compound

Blends of styrene butadiene rubber (SBR)/methyl-vinyl silicone rubber (MVQ) filled with dough molding compound (DMC) were prepared and the effects of various amounts of the SBR, as a compatibilizer of MVQ and DMC, on the mechanical properties and the oxygen index of the DMC filled SBR/MVQ blends were investigated. Dynamic mechanical analysis (DMA) and infrared spectrum analysis (IR) of the DMC/SBR/MVQ blends were also investigated. The results showed that the mechanical properties of the DMC filled MVQ blends were improved when SBR was used as a compatibilizer; the best mass ratio was 60 phr (parts per hundred total rubber) DMC, 25 phr SBR and 75 phr MVQ. The volume electric resistivities of the DMC filled SBR/MVQ blends with various DMC mass ratios were all above 5.8?×?10¹² Ω?m; i.e., the electrical insulating property of the blends was excellent. Compared with the blends without DMC and the blends without SBR, the energy storage modulus and the peak area of the loss factor tan δ of the DMC reinforced SBR/MVQ blends were largest; the addition of DMC and SBR improved the thermal properties of the blends.     

Design,Synthesis and Biological Evaluation of Novel Selective Thiol-based Histone Deacetylase(HDAC) VI InhibitorsBearing Indeno[1,2-c]pyrazole or Benzoindazole Scaffold

A series of thiol-based indeno[1,2-c]pyrazoles and benzoindazole compounds was designed and synthesized according to the structural specificity of histone deacetylase VI(HDAC6) and the structural characteristics of HDAC inhibitors. The inhibitory activities of the target compounds against HDAC6 and HDAC1 were screened by fluorescence analysis. Most of the target compounds showed moderate inhibitory activity against HDAC6(IC₅₀=44—598 nmol/L). Among them, compound A-4 displayed the highest selectivity against HDAC6 and similar inhibitory activity(IC₅₀=44 nmol/L) to that of the positive drug SAHA(IC₅₀=41 nmol/L) against HDAC6.     

High-selectivity Detection of 2,4,6-Trinitrophenol Based on Fluorescent Mg-MOF-74 in Ethanol Solution

Mg-MOF-74 has adsorption capacity while less research is about its luminescent properties. In this work, the fluorescent properties of Mg-MOF-74 were studied and characterized. The results show that Mg-MOF-74 exhibits excellent fluorescent properties and, most strikingly, selective sensing detection for nitroaromatic compounds(NACs), 2,4,6-trinitrophenol(PA) in particular, making it a promising PA-selective luminescent probe. This work demonstrates the application of MOFs in the detection of NACs with good selectivity.     

新型二硫杂环戊烯硫酮化合物的合成及其对谷氨酸诱导损伤HT22细胞的保护作用

在保留ADT-OH的3H-1,2-二硫杂环戊烯-3-硫酮结构的基础上,用芳乙烯基替换4-羟基苯环,设计并合成了6个二硫杂环戊烯硫酮化合物（L₁~L₆,其中L₂, L₃, L₅和L₆为新化合物）,其结构经¹H NMR, ¹³C NMR和HR-MS(ESI)表征。采用MTT法研究了L₁~L₆对谷氨酸诱导损伤的海马神经元HT22细胞的影响。药理初筛结果表明:给药浓度为10~100 μmol·L^-1时,L₁, L₂, L₄和L₆均能提高受损HT22细胞的存活率(P<0.01);给药浓度为1 μmol·L^-1时,L₃和L₅均可提高损伤HT22细胞的存活率(P<0.01)。     

四氢嘧啶类化合物的合成

以羰基衍生物,取代1,3-二羰基化合物,脲和硫脲为原料,经固定化青霉素酰化酶催化的Biginelli反应合成了22个四氢嘧啶类化合物（1a~1v）,其中1s和1v为新化合物,其结构经¹H NMR, ¹³C NHR和IR表征。研究了溶剂、反应温度、反应时间和物料比γ［n(苯甲醛) ：n(脲) ：n(乙酰乙酸乙酯)］对1a产率的影响。结果表明：在最佳反应条件（固定化青霉素酰化酶为催化剂,乙醇为溶剂,γ=1.0 ：1.5：1.0,于50 ℃反应6 h）下,1a产率最高（85%）。     

多取代1,4-戊二烯-3-醇的合成及其在螺环四氢喹啉衍生物合成中的应用

以取代邻氨基苯甲酸为起始原料,经6步反应合成了7个多取代1,4-戊二烯-3-醇（7a~7g）;以7a~7g为原料,5 mol%FeCl₃为催化剂,CH₂Cl₂为溶剂,于室温反应合成了7个螺环四氢喹啉衍生物（8a~8g）,其结构经¹H NMR, ¹³C NMR, IR和HR-MS(ESI)表征。采用X-射线单晶衍射研究了8d的晶体结构。结果表明：8d的晶胞参数a=14.001(3) , b=12.335(2) , c=11.587(3) , α=90°, β=95.497(2)°, γ=90°, V=1 991.9(7) ³, Z=4, μ=0.182 mm^-1, F(000)=816.0, R[F²>2σ(F²)］=0.053 7, wR(F²)=0.132 5。     

Strategy of improving the stability and detonation performance for energetic material by introducing the boron atoms

A novel stable energetic compound (E)‐1,2‐diamino‐1,2‐dinitrodiboron (DANB) was theoretically designed based on the structure of 1,1‐diamino‐2,2‐dinitroethene (FOX‐7). Atomization method in combination with Hess' law was used to predict the heat of formation. The detonation velocity (D) and detonation pressure (P) of DANB were approximatively estimated by using Kamlet–Jacobs equations. As a result, DANB has huge heat of formation (2013.5 kJ/mol) and specific enthalpy of combustion (?26.4 kJ/g). Furthermore, DANB possesses high crystal density (1.85 g/cm³) and heat of detonation (5476.0 cal/g), which lead to surprising detonation performance (D = 10.72 km/s, P = 51.9 GPa) that is greater than those of FOX‐7 (D = 8.63 km/s, P = 34.0 GPa) and CL‐20 (D = 9.62 km/s, P = 44.1 GPa). More importantly, DANB is very stable because its bond dissociation energy of the weakest bond (BDE = 357.8 kJ/mol) is larger than those of the most common explosives, such as FOX‐7 (BDE = 200.4 kJ/mol), CL‐20(BDE = 209.2 kJ/mol), HMX(BDE = 165.7 kJ/mol), and RDX (BDE = 161.4 kJ/mol). Therefore, our results show that DANB is a promising candidate for stable and powerful energetic material.     

酚化合物对胰岛素淀粉样纤维化的抑制作用

采用牛胰岛素作为模型多肽分子, 对几种结构相近的简单多酚的抗多肽淀粉样纤维化作用进行了研究. 结果表明, 邻苯二酚和对苯二酚对胰岛素纤维化具有抑制作用, 并通过形成醌中间体对多肽链进行修饰, 与对苯醌作用类似; 而苯酚和间二苯酚在相同条件下, 既不能修饰多肽也无抑制纤维化作用. 在无氧条件下, 邻苯二酚和对苯二酚对胰岛素纤维化的抑制作用明显降低, 说明酚化合物经氧化形成的醌中间体是其抗胰岛素纤维化的主要活性结构.     

Dy(Ⅲ)离子在LiCl-KCl熔盐中的电化学行为及Dy-Ni金属间化合物的选择性制备

采用循环伏安、方波伏安和开路计时电位等电化学方法研究了Dy(Ⅲ)离子在LiCl-KCl 共晶盐中的电化学行为及Dy-Ni 合金形成的电化学机理. 循环伏安和方波伏安法研究表明, Dy(Ⅲ)离子的电化学还原过程为三个电子转移的一步反应. 与惰性W电极相比, Dy(Ⅲ) 离子在Ni 电极上的循环伏安曲线多出了三对氧化还原峰,是由于Dy与Ni 形成了合金化合物, 导致Dy(Ⅲ)离子在活性Ni 电极发生了欠电位沉积. 采用X射线衍射(XRD)和扫描电子显微镜(SEM)附带能量散射谱(EDS)对恒电位(-1.6, -1.8 和-2.0 V)电解制备的Dy-Ni 合金进行分析, 分别获得了DyNi₅, Dy₂Ni₇和DyNi₂金属间化合物. 实验结果表明, 通过控制电位进行恒电位电解可以有选择性地制备不同的金属间化合物.