亚临床肝性脑病患者的血清锌,铜含量的测定及临床意义

检测了３０例慢性活动性肝炎患者、３０例肝硬化患者、３０例亚临床肝性脑病患者血清中的铜、锌含量，并与正常对照组进行比较分析，探讨了微量元素铜、锌的血清含量改变及其影响因素，分析其临床意义。结果表明体内的铜锌含量与肝脏功能有密切的关系。在慢性活动性肝炎时，虽然肝脏功能有一定的损害，但由于肝脏的代偿能力强，铜，锌含量仍可保持在正常水平，而在肝硬化、亚临床肝性脑病时，铜锌明显降低，而铜锌含量的降低又导致机     

内蒙古牧区蒙、汉族人发铜、锌、铁、锶及钙的X-射线荧光光谱法测定

用X-射线荧光光谱法，测定了387例内蒙古牧区蒙古族、汉族成人和儿童的发中铜(Cu)、锌(Zn)、铁(Fe)、锶(St)及钙(Ca)的含量，对同一地区蒙、汉族成人间，成人及儿童间发中五种元素含量进行了比较分析。结果表明：蒙汉族成人发中Cu，Zn、Fe含量不受种族及饮食习惯的影响，其含量无显著性差异；蒙汉族成人发中Sr和Ca含量存在着相平行的显著差异；牧区儿童发Zn含量与牧区成人发Zn含量差异无显著性意义，提示牧区儿童不缺Zn，可能与多动物性食物有关；牧区儿童发中Cu、Fe、Sr、Ca均显著低于牧区成人、可能与儿童发育旺盛和Zn摄入量高对Cu、Fe吸收发生抑制有关。     

微量元素缺乏症及其防治

报道了以235名健康小儿的血清锌、铜正常参考值及铜／锌比值作依据，对538名本地区集体儿童进行了调查．对240例不同病种患儿的血清锌、铜含量测定，并进行了分析；对G6PD、GSH-PX、AKP醇活性与微量元素含量的关系进行了相关性比较；对微量元素锌缺乏症的患儿进行了临床治疗观察；对微量元素缺乏症的防治进行了讨论．     

Catalytic enantioselective intermolecular reductive aldol reaction to ketones

We describe the first example of a catalytic enantioselective intermolecular reductive aldol reaction. Three types of reactions were studied: (1) reactions between acetophenone and methyl acrylate; (2) reactions between symmetric ketones and β-substituted α,β-unsaturated esters; and (3) reactions between acetophenone derivatives and an allenic ester. Although only moderate enantioselectivity was obtained in the first reaction type, high to excellent enantioselectivity was realized in the enantio-induction at the α-position in the second reaction type and at the δ-position in the third reaction type. Specifically, the third reaction type afforded the corresponding tertiary alcohols with up to 99% ee. Pre-activation of the nucleophile by silyl enolate formation is not necessary in these one-pot catalytic enantioselective reductive aldol reactions.     

Temporal evolution of Raman intensities on surface-enhanced Raman scattering active copper and gold electrodes at negative potentials

The effect of a roughening procedure on surface-enhanced Raman scattering (SERS) intensity of pyridine at copper and gold electrodes subjected to negative potential has been investigated. Among four procedures tested for a copper electrode the one consisting of electrochemical activation in a solution of LiCl and CuCl₂ resulted in the most stable and effective surface. It was proved that the presence of pyridine during the pretreatment procedure caused a very fast, irreversible decay of SERS intensity for both copper and gold electrodes. Quite stable, at least at room temperatures, gold surfaces were obtained by oxidation-reduction cycles activation in KCl solution.     

铜膜差分脉冲阳极溶出伏安法测定药物中铋的含量

研究了铜膜电极代替汞膜电极测定重金属铋的差分脉冲溶出伏安法。实验了同位镀膜法测定铋的条件。在最佳实验条件下,Bi3+浓度在5×10-8~2×10-5mol/L范围内,其溶出峰峰高与浓度呈线性关系,检出限达到1×10-8mol/L。测定了一些药物中铋的含量,结果准确。     

铜在HOPG上电沉积过程的现场ECSTM研究

用自制的电化学扫描隧道显微镜（ＥＣＳＴＭ）现场研究Ｃｕ在ＨＯＰＧ上的电沉积过程．结果表明Ｃｕ在ＨＯＰＧ上的电沉积为三维成核的过程．当电位较低或Ｃｕ２＋离子浓度较低时，铜在本体金属生长主要沿着台阶方向．过电位较高时，铜的成核数目增加，沉积层的晶粒有所细化．同时，非现场ＥＣＳＴＭ比较研究表明，ＳＴＭ针尖对针尖局部区域的电沉积起屏蔽作用，针尖所在区域Ｃｕ的沉积速度比其它区域明显减小     

Biological Activity of Flavonoids Copper Complexes

Three flavonoid copper(II) complexes Cu₂(quercetin)(CH₃COO)₃(CH₃OH) ( 1 ), Cu(anthrarufin)(CH₃COO)·1/2H₂O ( 2 ) and Cu(naringin)(OCH₃)(CH₃OH)₂ ( 3 ) have been synthesized and characterized by elemental analysis, IR, electronic absorption and EPR (X‐band) spectroscopy. The complexes have a strong protective action over the Δsod1 mutant of S. cerevisiae against reactive oxygen radicals generated by an external source of free radicals (H₂O₂ or the superoxide‐generating, menadione). On the other hand, the complexes cleave DNA efficiently even in the absence of reducing agents. The main reactive oxygen species responsible for the DNA strand cleavage have been determined using radical scavengers. A probably mechanism of the DNA damage is proposed.     

烟酸对酸性硫酸盐体系铜电沉积的影响

对溶液A: 0.8 mol•L－1硫酸铜,0.6 mol•L－1硫酸,5.0×10－5 mol•L－1氯离子,1.0×10－4 mol•L－1聚乙二醇的溶液,溶液B:在溶液A中加入2.0×10－2 mol•L－1烟酸,pH为0.5,运用循环伏安和计时安培法研究玻碳电极上铜的电沉积行为.结果表明,铜的电沉积过程经历了晶核形成过程,其电结晶按瞬时成核和三维生长方式进行.烟酸的加入对铜的电沉积具有阻化作用,但不改变铜的电结晶机理.沉积层的X射线衍射表明Cu为面心立方结构,在烟酸存在下沉积层出现(220)高择优取向,这可能是烟酸在Cu(220)晶面上发生强烈吸附作用的结果.     

流动注射在线共沉淀预富集火焰原子吸收法测定痕量铜

研究了以Ｎｉ＾２＋－ＤＤＴＣ为共沉淀载体，流动注射在线共沉淀预富集－火焰原子吸收光谱法测定痕量铜的体系，在０．３ｍｏｌ．Ｌ＾－１的硝酸介质中，铜离子在编织反应器中与Ｎｉ＾２＋－ＤＤＴＣ（产生共沉淀，并被收集在编织器内壁上，用甲基异丁基酮（ＭＩＢＫ）在线洗脱沉积物并引入火争原子化器中测定。当富集时间为４０ｓ时，４０μｇ．Ｌ＾－１的铜１０次测定的相对标准偏差为３．０％，灵敏度提高６０倍，检出限（３σ）