Fluorinated peptidomimetics: synthesis, conformational and biological features

Peptides modified with fluoroalkyl functions in key backbone positions have been scarcely studied so far. Thus, little is known about their synthesis, their structural and physico-chemical properties, and their biological features. Our interest in this field of research led to the development of stereocontrolled synthetic protocols, both in solution and in solid phase, for many different fluoroalkyl peptidomimetics, some of which are overviewed in this paper: (a) ψ[CH(CF₃)NH]-peptide mimics holding a great potential as hybrids between natural peptides and hydrolytic transition state analogs; (b) trifluoromethyl (Tfm) malic peptidomimetics as micromolar inhibitors of some matrix metalloproteinases; (c) bis-Tfm analogs of Pepstatin A, that are nanomolar and selective inhibitors of the protozoal aspartyl protease Plasmepsin II.     

超导磁体低温液位监测单元的设计与实现

介绍了一种应用于超导磁体的低温液位监测单元的设计与实现.设计了压控电流源电路和电压-频率转换电路用于液氦的液位测量,并设计了电容-频率转换电路用于液氮的液位测量;设计了以STM32微控制器为核心的数字电路,用于压控电流源的控制、频率信号的处理和液位监测数据的数字化显示;同时通过CAN总线把液位的监测数据自动发送至上位机,完成液位监测单元的远程控制.测试结果证明了该设计的可行性.     

Ceric Ammonium Nitrate (CAN)–Catalyzed Multicomponent Reactions: An Efficient Catalyst for Green Organic Synthesis

Multicomponent reactions (MCRs) consist of two or more synthetic steps carried out without isolation of any intermediate, which reduces time and saves money, energy, and raw materials. The development of MCRs in the presence of ceric ammonium nitrate (CAN) is an efficient approach that meets with requirements of sustainable chemistry. The aim of this review is to highlight the interactive effect of the combined use of MCRs and CAN for the development of new ecofavorable methodologies for synthetic organic chemistry. There are many advantages to the use of CAN as a catalyst in organic synthesis, including the very small amount of this catalyst needed to complete reactions in most cases, lower costs, ecofriendly nature, ease of handling, nontoxicity, and high reactivity.     

基于CAN总线的楼宇温度检测系统

基于单片机实现传统温度检测技术的特点，提出了基于CAN总线的楼字温度检测系统方案．该系统方案的硬件平台主要包括温度检测模块和主控平台，并详细介绍了其硬件实现、软件设计思想及流程．实验表明：该系统可实现对楼宇温度的实时检测，并由LCD显示检测结果，对异常情况进行语音报警，从而实现对楼宇房间温度的有效监测．     

An efficient and rapid dehydrogenation of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using CAN/HCl

An efficient and operationally simple method for the dehydrogenation of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed using CAN/HCl.     

用微机和CAN总线改进热学实验

用片上自带CAN的微控制器P8XC5 91、数字温度传感器DS1 8B2 0和微机组成温度测试网络系统 ,改进了热学实验 .本文详细叙述了该系统的硬件电路、软件及通信设计     

基于3G网络和CAN总线的汽车远程控制系统设计

针对传统汽车远程控制系统时延高、安全性差等问题,提出了新的远程控制方案,实现了远程服务器通过车载控制终端对车载网络中各节点设备的远程控制;在远程服务器与车载控制终端通信过程中采用3G网络、TCP协议和AES加密,降低了系统的通信时延,提高了系统的可靠性和安全性;车载控制终端与各节点设备采用CAN总线网络进行通信,实现了对各节点的有效控制;经过测试,系统能很好地满足远程服务器对车门窗、车灯、报警器和发动机等节点设备远程控制时延和安全性的要求,各节点响应快,可靠性高,具有较强的实时性和良好的扩展性。     

Arduino控制器CAN驱动模块的设计

随着Arduino控制器在测控系统和通信系统中的广泛应用,其CAN总线模块的开发技术日益关键,故将Arduino控制器的CAN驱动设备创建作为研究对象,从硬件电路设计到底层驱动开发进行了详细研究,以Simulink作为开发环境,采用嵌入式Matlab函数模块创建CAN驱动模块,并以实际电机应用例子的通信实验验证模型的准确性和可靠性。通过CANoe测试软件采集的传输通信数据,结果表明基于Simulink开发的CAN通信模块调试成功。这不仅为后续系统级的开发奠定了良好的通信基础,也给其他驱动模块的开发带来了启发。     

基于CAN总线的电气火灾远程监控系统

为了解决传统电气火灾监控系统在远距离数据通信时误码率高、总线上可连接的终端节点数量少、传输速率低等问题,设计了一种基于CAN总线及STM32F103单片机的电气火灾远程监控系统。给出了系统的整体框架及其组成,重点阐述了火灾终端监控设备的硬件及软件设计思路,制订了火灾监控设备与上位机的通信协议。系统实现了消防联动设备的工作状态、被监控设备的供电电压、电流,被保护用电设备的剩余电流值,以及用电设备工作的环境温度的实时监测,并通过CAN总线将监测状态实时传输到远端计算机。在实现火灾监控的基础功能上,增加了通过现场总线与现场其它监控设备通信的主机功能。测试结果表明,系统在远距离数据通信时传输速率提高、增加监控节点的情况下,系统间的数据通信误码率非常低。