THE POINT PROCESS OF STATETRANSITIONS IN AREGULAR MARKOV CHAIN

1.IntroductionInreliabilitytheory,inordertocalculatethefailurefrequencyofarepairablesystem,Shily]firstintroducedandstudiedthetransitionfrequencybetweentwodisjointstatesetsforafiniteMarkovchainandavectorMarkovprocesswithfinitediscretestatespaceandobtainedageneralformulaoftransitionfrequency.Then,ontheconditionthatthegeneratormatrixofMarkovchainisuniformlybounded,Shi[8'9]againprovedthetransitionfrequencyformulaandobtainedthreeotherusefulformulas.Obviously,thepoint(orcalledcounting)processofsta…     

Weierstrass型函数图象的分形维数

考虑函数f(x)=sum from i=1 to ∞(?)~(-1)φ((?) θ_n)和w(x)=sum from n=1 to ∞(?)φ_(?)((?)x θ_(?)),式中0<α<(?)是任意实数,在一定条件下,估计了函数f图象的Hausdorff维数的下界,并求得了w函数图象的Box维数和Packing维数。     

An interior-point affine-scaling trust-region method for semismooth equations with box constraints

An algorithm for the solution of a semismooth system of equations with box constraints is described. The method is an affine-scaling trust-region method. All iterates generated by this method are strictly feasible. In this way, possible domain violations outside or on the boundary of the box are avoided. The method is shown to have strong global and local convergence properties under suitable assumptions, in particular, when the method is used with a special scaling matrix. Numerical results are presented for a number of problems arising from different areas.     

关于γ—可重排列方面的一个计数公式

本文给也了规格为２＾ｍ的２ｍ个元的γ－可重排列的个数的一个计算公式。     

关于n进制及其有关计数函数

给出了n进制中数字之和函数均值A（N）的一个精确的计算公式。     

Large Deviations for Random Sums on Some Kind of Heavy-tailed Classes in Risk Models

This paper is a further investigation into the large deviations for random sums of heavy-tailed,we extended and improved some results in ref. [1] and [2]. These results can applied to some questions in Insurance and Finance.     

Two-Phase Image Segmentation by Nonconvex Nonsmooth Models with Convergent Alternating Minimization Algorithms

Two-phase image segmentation is a fundamental task to partition an image into foreground and background. In this paper, two types of nonconvex and nonsmooth regularization models are proposed for basic two-phase segmentation. They extend the convex regularization on the characteristic function on the image domain to the nonconvex case, which are able to better obtain piecewise constant regions with neat boundaries. By analyzing the proposed non-Lipschitz model, we combine the proximal alternating minimization framework with support shrinkage and linearization strategies to design our algorithm. This leads to two alternating strongly convex subproblems which can be easily solved. Similarly, we present an algorithm without support shrinkage operation for the nonconvex Lipschitz case. Using the Kurdyka-Łojasiewicz property of the objective function, we prove that the limit point of the generated sequence is a critical point of the original nonconvex nonsmooth problem. Numerical experiments and comparisons illustrate the effectiveness of our method in two-phase image segmentation.     

Integrated quality by design (QbD) and design of experiments (DoE) approach for UFLC determination of telaprevir in rat serum

An ultrafast liquid chromatographic bioanalytical method was developed and validated for the determination of telaprevir in Wistar albino rat serum. Principles of quality by design (QbD) were implemented for enhancing the bioanalytical liquid–liquid extraction of telaprevir from rat serum. A Box–Behnken design was utilized in the studies by selecting extraction time, centrifugation speed, and vortex time as the critical method variables for evaluating their effect on the critical analytical attribute, i.e., %recovery of telaprevir. Chromatographic separation was achieved within a run time of 10?min using a C-18 column and mobile phase comprising of methanol:borate buffer of pH 9 (90:10 v/v) flowing at 1.2?mL/min. Photodiode array detection was performed at 270?nm. Results of validation studies were satisfactory. The method was linear over a concentration of 25–10,000?ng/mL. Limit of detection for the developed method was 10?ng/mL. Further, design of experiments (DoE) used for inter-day accuracy and precision study suggested superior method reliability. This integrated QbD- and DoE-based approach ensured the development of a validated and reliable analytical method for optimum bioanalysis of telaprevir in biological matrix.