基于虚拟仪器的装备ATS系统硬件平台设计与实现

在对现有维修检测设备存在不足分析的基础上,结合武器装备的维修技术保障需求,利用分块设计思想,采用虚拟仪器、人工智能、计算机通讯与控制等技术,搭建了基于虚拟仪器的装备自动测试系统硬件平台整体架构,在对系统各功能模块原理进行分析之后,对系统主控电路、电磁兼容性进行了设计。采用虚拟仪器的装备自动测试系统硬件平台,具有智能化、通用化、可视化的特点,通过试验结果分析,测试系统硬件平台能够实现装备的性能检测和故障诊断,测试数据符合任务要求,能满足各级修理机构维修测试需求。     

战略导弹试验模拟系统开发平台设计

为满足新型武器系统靶场一体化联合试验、训练与保障的需求,克服传统面向具体导弹型号的模拟训练系统缺乏灵活性和扩展性的不足,提出了设计“试验模拟系统制造工厂”的新理念,即构建通用的战略导弹试验模拟系统开发平台,由用户根据具体导弹型号的需求,基于开发平台进行二次开发自行生产出特定的仿真训练系统。设计了试验模拟系统功能和开发平台结构,采用组件式、平台化、脚本化的开发思路,给出了开发平台的具体技术实现途径,包括：仿真模型设计、仿真服务总线设计、组件化/脚本化设计、设备模型仿真设计、原理仿真设计、信息流程可视化仿真设计、系统运行流程设计等,最后给出了飞行仿真的设计演示情况。所设计的开发平台将为试验、作战、指挥等岗位技术人员提供丰富的模拟训练及考核评估手段。     

Functionalized carbon nanotubes and nanofibers for biosensing applications

This review summarizes recent advances in electrochemical biosensors based on carbon nanotubes (CNTs) and carbon nanofibers (CNFs) with an emphasis on applications of CNTs. CNTs and CNFs have unique electric, electrocatalytic and mechanical properties, which make them efficient materials for developing electrochemical biosensors.We discuss functionalizing CNTs for biosensors. We review electrochemical biosensors based on CNTs and their various applications (e.g., measurement of small biological molecules and environmental pollutants, detection of DNA, and immunosensing of disease biomarkers). Moreover, we outline the development of electrochemical biosensors based on CNFs and their applications. Finally, we discuss some future applications of CNTs.     

Electrogenerated chemiluminescence aptamer-based method for the determination of thrombin incorporating quenching of tris(2,2-bipyridine)ruthenium by ferrocene

A novel electrogenerated chemiluminescence (ECL) aptamer-based biosensing method for the determination of thrombin was developed on basis of a structure-switching ECL-dequenching mechanism. A thiolated ss-DNA capture probe, composing of a ss-DNA sequence to adopt two distinct structures-a DNA double strand with a complementary DNA sequence tagged with a ECL signal producer tris(2,2^′-bipyridyl)ruthenium derivative and a DNA duplex with a thrombin-binding aptamer tagged with a ECL-quencher ferrocene (FcDNA), was self-assembled onto surface of a gold electrode. In the presence of thrombin, the aptamer sequence prefers to form the aptamer-thrombin complex and the switch of the binding partners occurs in conjunction with the generation of a strong ECL signal owing to the dissociation of FcDNA. The integrated ECL intensity versus the concentration of thrombin was linear in the range from 2.0 × 10⁻¹⁰ M to 2.0 × 10⁻⁷ M. The detection limit was 6 × 10⁻¹¹ M. The relative standard derivation for 2.0 × 10⁻⁹ M was 5.7% (n = 7). This work demonstrates that the sensitivity and specificity of ECL aptamer-based method for proteins can be greatly improved using quenching ECL signal producer by a chemical quencher such as ferrocene.     

A Colorimetric Biosensing Platform with Aptamers,Rolling Circle Amplification and Urease-Mediated Litmus Test

Here we report on an ultra-sensitive colorimetric sensing platform that takes advantage of both the strong amplification power of rolling circle amplification (RCA) and the high efficiency of a simple urease-mediated litmus test. The presence of a target triggers the RCA reaction, and urease-labelled DNA can hybridize to the biotinylated RCA products and be immobilized onto streptavidin-coated magnetic beads. The urease-laden beads are then used to hydrolyze urea, leading to an increase in pH that can be detected by a simple litmus test. We show this sensing platform can be easily integrated with aptamers for sensing diverse targets via the detection of human thrombin and platelet-derived growth factor (PDGF) utilizing structure-switching aptamers as well as SARS-CoV-2 in human saliva using a spike-binding trimeric DNA aptamer. Furthermore, we demonstrate that this colorimetric sensing platform can be integrated into a simple paper-based device for sensing applications.     

列车防滑器主机故障诊断系统设计

SAB型列车防滑制动系统应用于国内T型列车,数量多,为了提高列车防滑器主机故障检测和维修效率,针对SAB WABCO公司的SWKAS20C型列车防滑器主机,设计了元件级故障检测与定位专家系统。通过研究模拟电子电路故障诊断技术,设计了基于支持向量机的多故障分类器,用于主机模拟电路故障样本数据的训练和测试,并通过改进算法寻优向量机参数,提高了故障诊断的准确度。搭建了模拟列车运行环境的测试平台,用以模拟主机在多种状态下的故障模式;使用VS2010开发环境编写了MFC专家系统。     

关于实践型人才培养的探索

高校是培养高级专门人才的主阵地,有责任和义务培养大量的实践型人才来满足社会需求。因此,高校必须转变教育理念,充分认识到实践型人才培养的重要性,开拓各种有效途径培养大学生的实践能力。     

一种用于舰载无人机通信的天线伺服系统设计

为克服舰载设备使用稳定平台的可靠性问题,提出并设计了一种脱离稳定平台用于舰载无人机通信的天线伺服系统。该天线伺服系统用于舰艇对舰载无人机的实时跟踪,具有自动跟踪和手动跟踪两种工作模式,并且结构简单、工作稳定、响应速度快。从系统设计原理出发,阐述了系统的机电作动机构、角度跟踪算法、系统硬件电路设计以及伺服电机控制策略。实验表明,该伺服系统能够实时对舰载无人机进行精确跟踪,从而保障舰艇与无人机的有效通信。     

A brief review on miniaturized electrochemiluminescence devices: From fabrication to applications

Miniaturized electrochemiluminescence (ECL) systems are widely recognized as a highly detection, user-friendly, and turnkey strategy to develop point-of-care-testing devices. The ECL sensing approach provides numerous advantages over other methods, including high signal-to-noise ratio and measurement with minimal or no background signal. The ECL signal can be easily controlled by a small external potential while providing high sensitivity and decreased electrode fouling, resulting in the use of ECL-based miniaturized systems for detection and monitoring of different analytes, including DNA and bacteria. In this work, different types of miniaturized ECL systems with various fabrication techniques are reviewed and their application in point-of-care-testing is thoroughly discussed. Furthermore, such ECL platforms have been summarized based on the type of the ECL mechanism, electrodes, range of detection, and limit of detection. Finally, some of the upcoming technological interventions to make such a miniaturized ECL platform amenable for portable and on-field analysis have been discussed.     

化学专业学生线上学习平台和学习效果评价研究*

从学生视角简要介绍了钉钉、腾讯会议、腾讯课堂、中国大学MOOC、QQ群等多个在线学习平台的特点和使用方法。基于2020年第一学期高校开展线上教学的实践,通过对化学及相关专业本科生进行问卷调查,发现由于缺少纸质教材、师生互动不便、网络平稳性差、学生听课时自控力不好等原因,学生对居家线上课堂听讲情况、学习态度等的自我满意程度较在校学习时差,一定程度上影响了学生线上专业学习的效果。基于调查结果,从专业教师和学生2个方面就提升线上教学效果提出了建议。