排序方式: 共有53条查询结果,搜索用时 15 毫秒
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合成20种新的N-异丙基-S-丙基-N′-取代-N′-苯磺酰基硫(醇)代磷酰二胺酯化合物Ⅰ、Ⅱ。合成Ⅰ时,还分离出3种新的环状磷酰二胺酯内酯化合物Ⅲ,经~1HNMR、元素分析及MS证明了它们的结构。初步电生理测试表明,Ⅰ、Ⅱ类化合物对果蝇幼虫种经通道具有较好的阻断作用。 相似文献
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Anthony E. Beezer John C. Mitchell Rachel M. Colegate David J. Scally Lance J. Twyman Richard J. Willson 《Thermochimica Acta》1995,250(2):277-283
Calorimetry has for some time been proposed as a rapid method for determination of bioactivity. This paper describes the background to this application and describes how it has been extended to the study of bioassay techniques via microcalorimetry in the development of structure activity relationships (SARs). That SARs can be developed indicates that it is possible to guide drug synthetic strategy through the results of microcalorimetric investigations, and this approach is explored here. In an extension of this approach it is argued that microcalorimetry is well suited to the examination of novel drug delivery systems, allowing investigation of the capacity of drug delivery molecules to release the drug in the presence of a target organism. 相似文献
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Microchip technology has matured over the years into an important field in which novel technologies are being constantly invented,
and down-sizing and incorporation of already existing methodologies into the microscale is increasing assay performance and
bearing the promise of future total integration for simple, widespread use. One rapidly growing sub-discipline of the microchip
research field is focused around the integration of microchip technology and cell biology. In this review, we recapitulate
progress here at the Kitamori laboratory in direct relation to cell and microchip technologies, and show some examples of
successful integration of the two, going from controlled patterning of cells, on-chip cell culture stimulation, and cardiovascular
systems on a chip, to bio-microdevices integrating cardiovascular cells and microtechnology to create novel biodevices such
as biocompatible, miniature pumps. 相似文献
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三[(三甲硅基)亚甲基]锡芳香酸酯的研究 总被引:12,自引:1,他引:12
合成了14个三[(三甲硅基)亚甲基]锡芳香酸酯,IR光谱显示该类化合物为四配位锡的单体结构,^119Sn化学位移同苯环上对位取代基的Hammett常数间存在着良好的线性关系,生物活性测定结果表明,化合物的生物活性谱比相应的硅托尔克羧酸酯宽,且杀虫,抑菌效果更好。 相似文献
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研究了2-(三甲硅基)乙基硫代乙酸与(取代)苯胺和脂肪胺直接缩合反应或在五氧化二磷存在下的反应,发现前者收率高于后者。由此合成了17种结构新颖的2-(三甲硅基)乙基硫代(N-取代)乙酰胺类化合物。通过NMR(1H,13C)、IR和MS的研究,确定了这类化合物的结构,并探讨了化合物结构与波谱的关系。经测定,这些化合物的生物活性不甚理想。 相似文献
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IntroductionSince the first report of transgenic plants ap-peared in1 984[1] ,there has been a rapid progressdirecting toward using this new technique to im-prove crops. Protecting crops from insect pestsquickly became a major goal ofgenetic engineering.By far,the greatest research effort in developingpest- resistant transgenic crops has been devoted tothe expression of Bacillus thuringiensis( Bt) toxinin plants.The formulations based on bacterium Bacillusthuringiensis as a biopesticide for … 相似文献
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Mimicking Daphnia magna bioassay performance by an electronic tongue for urban water quality control
Dmitry Kirsanov Evgeny Legin Anatoly Zagrebin Natalia Ignatieva Vladimir Rybakin Andrey Legin 《Analytica chimica acta》2014
Toxicity is one of the key parameters of water quality in environmental monitoring. However, being evaluated as a response of living beings (as their mobility, fertility, death rate, etc.) to water quality, toxicity can only be assessed with the help of these living beings. This imposes certain restrictions on toxicity bioassay as an analytical method: biotest organisms must be properly bred, fed and kept under strictly regulated conditions and duration of tests can be quite long (up to several days), thus making the whole procedure the prerogative of the limited number of highly specialized laboratories. This report describes an original application of potentiometric multisensor system (electronic tongue) when the set of electrochemical sensors was calibrated against Daphnia magna death rate in order to perform toxicity assessment of urban waters without immediate involvement of living creatures. PRM (partial robust M) and PLS (projections on latent structures) regression models based on the data from this multisensor system allowed for prediction of toxicity of unknown water samples in terms of biotests but in the fast and simple instrumental way. Typical errors of water toxicity predictions were below 20% in terms of Daphnia death rate which can be considered as a good result taking into account the complexity of the task. 相似文献
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本文报道了22个新的4,5-二氧-(2-硫)-1,3,2,4-二氮二磷杂环戊烷化合物。对合成路线和条件作了初步探讨。产物的结构经IR、1H和31PNMR及元素分析得到证实,测定了部分产物的MS。在31PNMR谱中产物的顺式和反式异构体均得到了指认。部分产物的生物活性初步测定结果表明,它们具有一定的除草和抑菌活性。 相似文献