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61.
Highly regio- and stereoselective synthesis of tricyclic frameworks using Baylis-Hillman derivatives
Manickam Bakthadoss Nagappan Sivakumar Govindan Sivakumar Gandhi Murugan 《Tetrahedron letters》2008,49(5):820-823
A simple and convenient synthetic route for the synthesis of tricyclic chromeno[4,3-b]pyrrolidine frameworks using Baylis-Hillman bromides involving in situ formation of an imine, decarboxylation and a [3+2] cycloaddition sequence is described. 相似文献
62.
The first stereoselective total synthesis of trichodermone A using Baylis-Hillman and ring-closing metathesis (RCM) reactions as key steps is reported. 相似文献
63.
An easy, one-pot transformation of Baylis-Hillman adducts into carbamates of unsaturated β-amino acids, for example, 2-(aryl(methoxycarbonylamino)methyl)acrylic acid methyl esters 7 and 2-(methoxycarbonyl aminomethyl)-3-arylacrylic acid methyl esters 8 via reaction with the Burgess reagent is described. 相似文献
64.
Seung Chan Kim 《Tetrahedron letters》2006,47(20):3463-3466
We prepared some 3-aryl-3-hydroxypyrrolidin-2-ones and tricyclic 2-benzyl-9b-hydroxy-3,3a,5,9b-tetrahydro-2H-pyrrolo[3,4-c]quinoline-1,4-diones starting from the Baylis-Hillman adducts of isatin derivatives. 相似文献
65.
Syntheses of 2-amino-2,3-dihydrobenzofuran derivatives 3a-g and fully substituted furans 5a-f were achieved starting from the Baylis-Hillman adducts. We prepared 2-amino-2,3-dihydrobenzofurans from the Baylis-Hillman adducts of methyl and ethyl acrylates and fully substituted furans from the Baylis-Hillman adducts of alkyl vinyl ketones. 相似文献
66.
Sudharshan Madapa 《Tetrahedron》2006,62(37):8740-8747
An alternate approach to densely substituted quinolines from the products of SN2 nucleophilic substitution reaction between the acetyl derivatives of the Baylis-Hillman adducts obtained from 2-nitrobenzaldehydes and the carbonyl group containing carbon nucleophiles is described. Treatment of these compounds with SnCl2, triggers a tandem reaction wherein reduction of the nitro group is followed by a remarkably regioselective intramolecular cyclization and subsequent dehydrogenation to afford 4-(substituted vinyl)-quinolines. 相似文献
67.
I. David Reingold Charles Bowerman Robert S. Walters Jr. Anna M. Butterfield 《Tetrahedron letters》2006,47(10):1653-1655
A tricyclic ketone is formed from cyclohexanone and cyclohexenone in strong acid solutions. The structure is confirmed by X-ray crystallography. 相似文献
68.
Sequential Baylis-Hillman/ring-closing metathesis (RCM) approach toward the total synthesis of (+)-MK7607 and (+)-streptol starting from (R,R)-tartaric acid is reported. 相似文献
69.
An efficient and regioselective introduction method of 2-methylpyridines to the secondary position of Baylis-Hillman adducts has been developed. A base treatment of 2-methylpyridinium salt of Baylis-Hillman bromide generated N-allylenamine intermediate which underwent a facile 3-aza-Cope rearrangement under mild conditions to produce the product. 相似文献
70.
Hoo Sook Kim 《Tetrahedron letters》2009,50(26):3154-9061
Modified Baylis-Hillman adducts having 2-bromoaniline moiety at the primary position underwent Pd-mediated reductive Heck type cyclization to produce dihydroindole derivatives. The same starting materials can also be used for the synthesis of indole derivatives under slightly different conditions via the concomitant δ-carbon elimination and decarboxylation process. 相似文献